Printer Friendly

Measles found to suppress HIV.

A study in Africa found that viral load was apparently reduced by almost two logs during acute measles infection in children. After they recovered from measles, the HIV viral load came back. (1)

Interpretation was complicated by the fact that no baseline viral loads were available for the children before they came down with measles. Instead, researchers measured viral load in children who had been hospitalized with measles, and found it surprisingly low -- a median of 5,339 copies. This compared to 387,000 copies in the same children at a one-month followup, after they had recovered from measles. A comparison group of children with HIV but without measles or other acute illness had a median viral load of 228,000.

This reduction was all the more remarkable since an illness like measles would be expected to raise the viral load if it did anything -- due to increased immune activation.

Comment

At least one other disease -- scrub typhus -- has also been found to suppress HIV, but only in some patients. (2)

Clearly we need research to identify the exact mechanism of viral suppression by measles or certain other diseases. It might be possible to use this knowledge to design a new class of treatment for HIV.

References

(1.) Moss WJ, Ryon JJ, Monze M, Cutts F, Quinn TC, and Griffin DE. Suppression of human immunodeficiency virus replication during acute measles. The Journal of Infectious Diseases. 2002; volume 185, pages 1035-1042.

(2.) Watt G, Kantipong P, de Souza M, and others. HIV-1 suppression during acute scrub-typhus infection. The Lancet. August 5, 2000; volume 356, pages 475-479.
COPYRIGHT 2002 John S. James
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Publication:AIDS Treatment News
Geographic Code:60AFR
Date:Apr 12, 2002
Words:265
Previous Article:Retroviruses conference: Some new drugs in the pipeline.
Next Article:New cancer drugs might help treat HIV -- but research not done.
Topics:


Related Articles
HIV can linger years with no antibodies.
Immune factor inhibits the spread of HIV.
Body's proteins suppress AIDS virus.
Second protein opens cells in HIV's entry.
Multiple doors for HIV to enter cells.
Same gene, two plagues?
A look at HIV immune research.
Modern HIV may be slightly less virulent, laboratory study suggests.
Plumbing HIV pathogenesis.
The road to a cure.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters