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May improve compliance: extended-release ciprofloxacin shown safe, effective in study.

A new once-daily extended-release formulation of ciprofloxacin that could enhance treatment compliance was as safe and effective as conventional twice-daily ciprofloxacin for the treatment of complicated urinary tract infections and acute uncomplicated pyelonephritis in a recent study.

Of 435 patients with a clinical diagnosis of complicated UTI or acute uncomplicated pyelonephritis in the prospective, randomized, double-blind trial, 206 patients received 1,000 mg once-daily ciprofloxacin extended release, and the remaining 229 received 500 mg ciprofloxacin twice daily.

Patients in both groups were treated for 7-14 days, said Dr. David A. Talan of the University of California, Los Angeles, and his colleagues.

The bacteriologic eradication rate was 89% in the once-daily group and 85% in the twice-daily group, and the clinical cure rate was 97% in the once-daily group, and 94% in the twice-daily group (J. Urology 171[2]:734-39, 2004).

Drug-related adverse event rates were similar for the once-daily group and the twice-daily group (13% vs. 14%). Events included nausea, vaginal moniliasis, diarrhea, headache, and dizziness.

Chlamydia Rates Rising

Per 100,000 Population

1992 183.4
1994 194.5
1996 193.7
1998 236.7
2000 252.1
2002 296.5

Source: Centers for Disease Control and Prevention

Note: Table made from bar graph.
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Title Annotation:Gynecology
Author:Worcester, Sharon
Publication:OB GYN News
Date:Mar 15, 2004
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