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Markers predict CHF progression. (Clinical Capsules).

Among patients with mild to moderate chronic heart failure, three markers identify those at high risk of "entering a decompensated spiral of declining ventricular function, hemodynamic deterioration, and death" from progressive congestive heart failure, reported Dr. Mark T. Kearney of King's College, London, and his associates.

They followed 553 ambulatory patients with mild or moderate congestive heart failure (CHF) for 5 years to determine which markers of autonomic and neuro-hormonal dysfunction might predict death from progressive CHF. The subjects had a wide range of ejection fractions and were representative of patients typically seen in cardiology and internal medicine practices (J. Am. Coll. Cardiol. 40[10]:1801-08, 2002).

There were 76 deaths from progressive CHF. Low serum sodium levels, a low standard deviation of all normal-to-normal RR intervals on ECG (an index of total heart rate variability), and high serum creatinine levels were found to be independent and specific predictors of CHF mortality regardless of the degree of systolic dysfunction or the etiology of heart failure.
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Title Annotation:congestive heart failure
Author:Moon, Mary Ann
Publication:Internal Medicine News
Article Type:Brief Article
Date:Jan 15, 2003
Previous Article:Screening for aortic aneurysm. (Clinical Capsules).
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