Markers of nasal toxicity for naphthalene.
Naphthalene is a volatile hydrocarbon that causes dose-, species-, and cell type-dependent cytotoxicity after acute exposure and hyperplasia/neoplasia after lifetime exposures in rodents. The toxicity of naphthalene depends on metabolic activation, and reactive metabolite binding depends on tissue and site susceptibility. To identify possible markers of toxicity, DeStefano-Shields et al. (p. 647) compared proteins adducted in nasal epithelium from rats and rhesus macaques in vitro following exposure to naphthalene. Although rates of naphthalene metabolism to water-soluble metabolites in nasal airways have been reported to differ in rodents and monkeys, such species differences were not reflected in covalent adduct formation. This finding raises suggests that the downstream metabolic/biochemical events associated with toxicity and tumorigenicity in rodents may be similar to those in rhesus monkeys, a species similar to humans.
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|Publication:||Environmental Health Perspectives|
|Article Type:||Brief article|
|Date:||May 1, 2010|
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