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Management of the child with polymicrogyria.

ABSTRACT

Polymicrogyria is one of several neuronal migrational defects. This disorder is derived from a malformation in cortical development characterized by many small gyri, shallow sulci, and abnormal cortical layering. The potential causes of polymicrogyria include genetic disorders, intrauterine cytomegalovirus infection, and fetal vascular supply disruption. A wide variation in the extent of findings exists, ranging from minor deficits to profound neurological dysfunction. Seizures, feeding problems, elimination, physical mobility, and psychosocial issues must be managed for children with polymicrogyria. Children with this disorder require collaborative care from healthcare practitioners and parents to achieve their highest level of health. The incidence of neuronal migrational defects is approximately 1 in 2,500 live births (L. Villard et al., 2002). The diagnosis of these disorders has increased with improvement of magnetic resonance imaging (MRI) technology (A. J. Barkovich, R. Hevner, & R. Guerrini, 1999).

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When a child is diagnosed with polymicrogyria, it can be emotionally devastating because the parents are forced to face the loss of what could have been and the reality of what will be. This article will summarize the pathophysiology of polymicrogyria and its definition, causes, and clinical manifestations; typical patient management issues; and the need for collaborative healthcare. Education and support needs of the patient and/or parent will be emphasized.

Pathophysiology and Etiology

During normal fetal development, neurons migrate from the innermost layer of the neuronal tube to the surface of the brain (Uher & Golden, 2000). This process is essential for the development of the cerebral cortex, which is responsible for higher level cognitive functioning such as judgment, language, and abstract thinking. The cortex is also involved in sensation interpretation and voluntary motor activities (Ciechanowski, Mower-Wade, McLeskey, & Stout, 2005). Different areas of the cortex are involved in various functions such as mobility, verbal skills, vision, and ability to eat effectively.

Neuronal migrational disorders occur when the cells do not properly migrate to the cortex, causing cerebral cortical malformation and resultant impairment in neurological function. Neuronal migrational defects include lissencephaly, pachygyria, heterotopia, focal cortical dysplasia, and polymicrogyria. Lissencephaly is characterized by a smooth brain surface due to a lack of gyri and sulci. In pacygyria, there are areas where the brain is smooth, but it does not involve the complete agyria that is present in lissencephaly. Heterotopia is an ectopic collection of neurons which can be located superficially close to the ventricle (Uher & Golden, 2000). Focal cortical dysplasia may involve mild cortical disorganization or may include abnormal neurons (Wang, Chang, & Barbaro, 2006). Polymicrogyria is characterized by abnormal fetal cortical development which results in many small gyri with shallow sulci and abnormal cortical layering (Villard et al., 2002).

The etiology of polymicrogyria is not definitively known. Potential causes include in utero infection with cytomegalovirus, a placental perfusion deficit, or a genetic component (Jansen & Andermann, 2005). Some possible environmental risk factors include exposure to ethanol, retinoic acids, methylmercury, and radiation (Golden, 2001).

Patterns of Polymicrogyria With Associated Clinical Manifestations

The cortical defects of polymicrogyria can be focal or diffuse, bilateral or unilateral. Expressions of the disease range from minor impairment of cognitive function without seizure activity to major neurological dysfunction with intractable seizure activity (Jansen & Andermann, 2005). Several patterns of polymicrogyria have been identified based on the location and extent of the defect in the cortex (Villard et al., 2002). These patterns include bilateral frontal polymicrogyria, bilateral frontoparietal polymicrogyria, bilateral perisylvian polymicrogyria, bilateral generalized polymicrogyria, and bilateral parasagittal parieto-occipital polymicrogyria. The signs and symptoms relative to the specific patterns correlate to the part of the cortex involved (Jansen & Andermann, 2005).

The patient with bilateral frontal polymicrogyria often presents with a delay in motor and language development. Other associated findings include mild to moderate mental retardation and hemiparesis or spastic quadriparesis (Guerrini, Barkovich, Sztriha, & Dobyns, 2000). Seizures are present in approximately 38% of these patients and vary in severity, type, and age of onset (Jansen & Andermann, 2005). Table 1 lists classifications of seizures and contains the description of clinical manifestations.

Evidence of bilateral frontoparietal polymicrogyria is similar to that of bilateral frontal polymicrogyria. Patients typically experience serious delays in mental and motor development (Sztriha & Nork, 2002). One of the distinguishing signs in the patient with bilateral frontoparietal polymicrogyria is a dysconjugate gaze such as esotropia. Cerebellar dysfunction is likely, and seizures are present in 94% of these patients, typically of the generalized type (Jansen & Andermann, 2005).

Bilateral perisylvian polymicrogyria is the most common form of polymicrogyria. Its distinguishing feature is pseudobulbar involvement, causing issues with feeding, drooling, and dysarthria (Jansen & Andermann, 2005). Mild mental retardation and seizure disorders are also demonstrated in this form of polymicrogyria (Villard et al., 2002). Patients may present with infantile spasms, but it is more likely that seizures develop later in life. The seizures may be of multiple types, and often, seizure control is difficult (Jansen & Andermann, 2005).

Patients with bilateral generalized polymicrogyria have severe clinical deficits. Cognitive and motor developmental delays and seizure disorders are common. If the perisylvian region is involved, feeding issues may be present (Chang et al., 2004). In addition, the child may experience spastic hemiparesis or quadriparesis (Jansen & Andermann, 2005). Findings of bilateral parasagittal parieto-occipital polymicrogyria include seizure activity, impaired cognitive functioning, and average to low IQ scores. Partial (focal) seizures are often present and typically intractable (Jansen & Andermann, 2005).

Management of the Child With Polymicrogyria Seizure Management

Seizure activity affects many children with the diagnosis of polymicrogyria. Priority nursing diagnoses include risk for injury and risk for aspiration (see Table 2). The seizures are often managed by antiepileptic drugs (see Table 3), and the specific drug prescribed depends on the seizure type the child is experiencing. It should be noted the seizure type may change as the child ages. These changes often occur during adolescence at which time drug therapy may need to be adjusted. Drag regimens may be altered based on the effectiveness of the seizure control and the adverse reactions the child may experience. Another consideration when starting a child on antiepileptic drags is monotherapy versus combination therapy. Monotherapy is preferred; however, additional drugs may need to be added to achieve seizure control. When new drugs are added, the child must be monitored for the development of adverse reactions. It is important to note that most antiepileptic drugs can cause sedation and dizziness because they are central nervous system depressants (Benbadis & Tatum, 2001). Adverse reactions may intensify with higher drug doses and/or implementation of combination therapy.

A child with polymicrogyria may experience stares epilepticus which is defined as a continuous or cluster of seizures lasting longer than 20 to 30 min during which the child does not regain consciousness (Bryant, 2005). This is an urgent and emergent situation. In the home or community setting, treatment options for this situation include rectal diazepam, intranasal midazolam or lorazepam, and buccal midazolam (Ahmad, Ellis, Kamwendo, & Molyneus, 2006; McIntyre et al., 2005).

Children with polymicrogyria will be managed at home or in long-term care facilities. Part of the nurse's responsibility is to teach parents and other caregivers about the use of antiepileptic drags (see Table 4). Some seizures are not adequately controlled with these drugs, and children may experience adverse reactions. Alternative therapies may be suggested as options to assist in the management of seizure activity including the ketogenic diet and the vagus nerve stimulator (see Table 5). Antiepileptic drag therapy may be minimized or discontinued if the child has a positive outcome from these alternative therapies. Nurses should be knowledgeable about these treatment modalities and educate parents as needed.

Feeding Management

Some children with polymicrogyria have difficulty in meeting their daily oral intake needs, contributing to an alteration in nutrition. This nutritional deficiency may be related to ineffective oropharyngeal muscular coordination, potentially resulting in difficulty swallowing and aspiration. Signs of altered nutrition include loss of weight, alteration in growth and development, increased length of feeding times, and oxygenation interferences related to infections and structural damage to the lungs (Craig, Scambler, & Spitz, 2003). These children are also at risk of vomiting and development of gastroesophageal reflux (Guerriere, McKeever, Llewellyn-Thomas, & Berall, 2003).

A clinical nutritionist should be consulted to assess the adequacy of the child's diet. It is important for the child to maintain a desired body weight to avoid complications of being overweight or underweight. Types of seizures that are manifested by an increase in muscular activity can raise the caloric requirement (Wilson, 2005b). If the child is immobile, added weight can cause difficulty for the parent when transferring the child. In addition, obesity can contribute to the development of type 2 diabetes mellitus, coronary artery disease, respiratory dysfunction, arthritis, stroke, and certain types of cancer (Winkelstein, 2005). Obesity can also be associated with hypertension and the potential for skin breakdown. For these reasons, weight should be monitored regularly.

If nutritional needs cannot be met with oral feedings, a gastrostomy tube may be recommended. Information to be discussed with the parents should include details of the procedure of gastrostomy tube placement including anatomical location of the tube and anticipated postprocedure appearance of the child. Advantages and disadvantages of gastrostomy feeding, side effects of tube feeding, and the mechanics of administration of the formula and medications via the feeding tube should be discussed (Guerriere et al., 2003). Typically, formula is administered by bolus feeding, continuous, or cyclic infusion. Bolus feeding is less restrictive and may not limit daily activities as significantly as continuous feeding (Enrione, Thomlison, & Rubin, 2005).

Education of the parent should begin prior to placement of the tube so that informed consent can be given (Craig et al., 2003). However, ongoing assessment of learning should continue, and information should be shared with parents in manageable doses. Positive outcomes of feeding via a gastrostomy tube include an increase in weight, an improvement in nutritional status, an improvement in growth, and decreased incidence of illness and infection. Disadvantages of gastrostomy feeding have been identified as concerns regarding performance of yet another procedure on the child as well as anxieties regarding whether there will be ample benefits of tube feeding. A gastrostomy tube can intensify feelings that the family unit is not normal because of mealtime changes related to feeding via a tube (Guerriere et al., 2003). Another concern is that enteral feeding may increase the difficulty of finding a babysitter or respite care (Rollins, 2006). There will be changes in family routines and potential restriction of activity and leisure time related to the enteral feedings. For some families, the psychosocial issues are more difficult than the associated medical problems with enteral feedings (Enrione et al., 2005). Inpatient programs such as Family-Centered Service and Creating Opportunities for Parent Empowerment can be utilized and continued after discharge (Craig et al., 2003).

Gastroesophageal reflux disease (GERD) can occur in up to 70% of children with neuromuscular involvement such as polymicrogyria (Craig et al., 2003). This can occur if the child is being fed orally or through a gastrostomy tube. A Nissen fundoplication may be necessary for the relief of the symptoms of gastroesophageal reflux disease. This surgery involves the wrapping of the fundus of the stomach around the distal portion of the esophagus for the prevention of gastric reflux. Potential complications of this surgery include the breakdown of the wrap, infection, gastric distention, and retching (Daigneau, 2005). When a child has this procedure, it is essential to limit the volume of formula administered at any one feeding. It is also important to check the residuals prior to each feeding, and if the residuals are greater than the amount specified by the surgeon, the formula is withheld for a specified time. When there is too much volume in the stomach, it can cause the Nissen to come unwrapped.

Management of Impaired Elimination

Children with polymicrogyria are potentially at risk for multiple issues with elimination. Priority nursing diagnoses to consider include urinary retention and constipation. Neurological impairment can lead to a lack of or a delay in bladder control because maturity of the neurological system is necessary to achieve urinary continence (Roijen, Postema, Limbeek, & Kuppevelt, 2001). The neurological dysfunction in polymicrogyria may lead to the development of neurogenic bladder. Children with neurogenic bladder may have difficulty with completely emptying the bladder and may also be unable to initiate the flow of urine (Lemke, Kasprowicz, & Worral, 2005).

The healthcare professional should educate the parents regarding effective management of the child's urinary elimination. The goal of care should focus on effective bladder emptying and prevention of urinary tract infection. See Table 2 regarding the nursing diagnosis of urinary retention. Intermittent catheterization may be necessary for bladder management to prevent urinary retention, but this increases the risk of urinary tract infection. Sterile technique is utilized in most healthcare agencies, and parents are often taught clean technique of catheterization for home management. Current literature indicates that the clean technique is acceptable because it is cost-effective without significantly increasing the risk of urinary tract infection. Additional research may need to be conducted (Lemke et al., 2005).

The neurological impairment of polymicrogyria can lead to neurogenic bowel which refers to colon dysfunction related to a neurological disease or damage. Signs and symptoms include constipation, abdominal pain, and distention. The goal of care is to promote regular bowel movements (Coggrave, 2005).

See Table 2 regarding the nursing diagnosis of constipation.

Management of Impaired Physical Mobility

Children with polymicrogyria frequently experience some degree of impaired physical mobility. Impaired physical mobility has been defined as limited independent movement (Hur, Park, Kim, Storey, & Kim, 2005). Nursing interventions are included in Table 2.

Parents should be taught to monitor the child for evidence of complications of impaired physical mobility. The potential for complications will vary with each child as the degree of the impairment in physical mobility differs according to the level of neurological dysfunction. Some of the complications for which parents and healthcare professionals should assess include loss of joint mobility and muscle mass, osteoporosis, edema, skin breakdown, and infection. Others include decreased chest expansion leading to inadequate oxygenation, poor cough, respiratory infection, thrombus formation from venous stasis, constipation, and urinary retention (Wilson, 2005a).

Bone demineralization is a potential complication of impaired physical mobility. Proper nutrition including an adequate supply of calcium and vitamin D is essential to minimize this potential complication. Some antiepileptic medications such as phenytoin and phenobarbital may increase the risk of bone demineralization. Children with impaired physical mobility may be required to have dual emission x-ray absorptiometry scans to monitor bone mineral density (Palisano & Lally, 2007).

Assistive technology can be utilized to promote independence with activities of daily living to the highest degree possible considering the child's neurological status (Palisano & Lally, 2007). Assistive technology includes equipment for positioning, mobility, and lifting. The home environment may need to be altered with ramps and widened doors and with bathroom modifications to assist with bathing and toileting. Funding for these modifications may be possible through community resources. Visitation by a home care nurse or occupational therapist would be beneficial to assess the home environment and guide implementation and evaluation (Palisano & Lally, 2007).

Seating systems are important as the upright position assists in minimizing the potential complications of impaired physical mobility. The child's neurological dysfunction will guide the specific seating system, but components to consider include a headrest, seat and back inserts, anterior and lateral trunk supports, and arm and leg supports. A shoulder harness and seat belt may be needed to ensure safety if a child uses a wheelchair (Palisano & Lally, 2007). Position changes while in the wheelchair should be considered to relieve pressure and prevent skin breakdown. Often, orthotics are utilized to aid in maintaining the child's functional ability. One such example is the ankle--foot orthotic, which helps to maintain the correct angle of the ankle and foot for walking or positioning while sitting in a wheelchair. The ankle-foot orthotic can also be used to prevent further deformity of the joint. Referrals to occupational and physical therapists may be needed because these professionals have the most up-to-date information on available equipment to assist with transfer, hygiene, strengthening, and positioning.

Management of Psychosocial Issues

When a child is diagnosed with a chronic condition such as polymicrogyria, the entire family is affected. The dream of having a typical child is no longer a reality, and the family will experience many changes over time. Many of these children may live into adulthood and will be cared for in the home or communities by their parents or caregivers (Meleski, 2002).

Any chronic illness is stressful. An important factor to note is that parents had many responsibilities prior to the birth of a child with chronic disabilities. With the additional responsibilities that must be managed, the stress level of the family may increase and can lead to frustration and exhaustion (Enrione et al., 2005).

Certain factors or transitional times can be very stressful for the families of children with chronic disabilities. Five such transitional events have been identified and include receiving the initial diagnosis, reorganizing tasks within the family, performing skills necessary to manage the condition, recognizing the child's failure to reach appropriate age-related milestones, and observing a change in the course of the child's illness (Meleski, 2002). It is helpful for the healthcare professional to be aware of these transitional times and to intervene with encouragement and guidance to help the family adapt to the situation. Interventions include providing support options, sharing information about the disorder, helping in the management of the child, supporting families with role changes, and assisting families with normalizing their lives (Meleski, 2002).

Family assessments should be completed to determine needs. Support is extremely beneficial for families to better adapt to the child's condition. Assessment of their support systems should be conducted during times of transition. This support can come from the extended family, healthcare professionals, spiritual sources, and support groups for families of children with chronic illness or disabilities (Meleski, 2002). One support group that is very specific for the family of a child with polymicrogyria is the Lissencephaly Network which has a Web site (http://www.lissencephaly.org/). This is a nonprofit organization that serves children and families affected by lissencephaly and other neuronal migrational disorders including polymicrogyria.

When parents understand the child's condition and potential prognosis, they are better able to realistically plan for the future. Healthcare professionals can continue to educate the parents regarding the nature and progression of this disorder to help them anticipate possible limitations and needed adaptations (Meleski, 2002). Management of the child typically falls into the hands of the parents, and a positive relationship with the healthcare provider is important to enhance communication and facilitate a positive outcome for the family. A multidisciplinary approach is beneficial. The parents may need to learn about new skills, medications, use of equipment, and new technologies as appropriate (Meleski, 2002). Parents also need to be educated about the child's right to an education in the least restrictive environment. Personnel from the child's school district can be helpful in giving the parents this information.

The family members will most likely experience changes in their roles and responsibilities as they care for the child with chronic disabilities (Meleski, 2002). The lives of the members of the family will be changed forever. To manage, parents may have to make subtle and/or major changes in their routine. Often, the mother may decrease the number of hours worked outside of the home or the father may increase his number of hours worked (Seltzer, Greenberg, Floyd, Pettee, & Hong, 2001). Siblings of the child with disabilities may take on new responsibilities as well.

Families want to be as normal as possible while caring for their child with a disability. Several interventions can be helpful to assist the family in normalizing their lives. Assessing the families' needs in terms of support systems, coping strategies, and community resources will be helpful in planning appropriate interventions. Some of these include the distribution of tasks, how to coordinate normal routines and care of the child with the disability, and making available names of community services that may be appropriate for the family (Brown-Hellsten, 2005). Parents need to be told to take time for themselves to better enable them to manage the ongoing care of their child (Meleski, 2002).

Polymicrogyria can be a devastating condition for the child and family because management is complex. As neuroscience nurses, we must remember that it is the family who is the most constant variable in the child's life (Meleski, 2002). Listening to the parents is essential when caring for the child, and including the parents in the management is important to help obtain the best possible outcome. Education of the parent regarding the management of clinical manifestations is an important role of the healthcare professional. Anticipatory guidance helps decrease the stress of caring for a child with a chronic disability. A multidisciplinary approach will help address the many different needs of children with polymicrogyria and their families.

Acknowledgment

We dedicate this article to Ashley Turkelson, who was diagnosed with polymicrogyria shortly after her birth. She is the inspiration behind the development of this article. We learn so much from children like Ashley. We hope this article will be beneficial for healthcare providers and caregivers.

References

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Questions or comments about this article may be directed to Sandra L. Turkelson, MSN RN, at turkelsons@nku.edu. She is an associate professor at the Northern Kentucky University, College of Health Professions, Highland Heights, KY.

Caron Martin, MSN RN, is an associate professor at the Northern Kentucky University, College of Health Professions, Highland Heights, KY.
TABLE 1. Classification of Seizures (Fitzsimmons
& Bohan, 2005; Sierzant, 1999)

 Sub-
Classification classification Description

Partial Simple Consciousness is not impaired, may
seizures partial involve altered sensory or motor
 activities, autonomic symptoms such
 as flushing or tachycardia, psychic
 symptoms such as feelings of fear,
 seizure may go unnoticed, duration
 of several seconds or minutes

 Complex Consciousness is impaired,
 partial behaviors may include automatic
 activities (automatisms) such as
 chewing, swallowing, walking,
 fumbling with objects, duration of
 a minute to several minutes

 Partial May generalize from simple partial
 seizures or complex partial, may start as
 secondarily simple partial then complex partial
 generalized and then generalize

Generalized Tonic-clonic (Grand mal) loss of consciousness,
seizures stiffening (tonic phase), rhythmic
 jerking (clonic phase),
 respirations may be shallow or
 absent, may last greater than 60
 seconds

 Absence Brief staring, blinking of eyes,
 chewing movements

 Myoclonic Brief body jerks, last seconds but
 may occur serially

 Atonic (Drop attacks), loss of muscle
 tone, falls, loss of consciousness

 Tonic Sudden increased tone

 Clonic Bilateral jerking

Unclassified These include some neonatal
seizures seizures

TABLE 2. Potential Nursing Diagnoses With Related
Interventions and Rationales (Bryant, 2005; Coggrave,
2005; Forsyth & Garnett, 2007; Lemke et al., 2005;
Palisano & Lally, 2007)

Nursing
Diagnoses Nursing Intervention Rationale

Risk for Keep bed in low To decrease the risk
injury position. Keep side of physical injury
 rails up. in the event of a
 seizure
 Pad side rails.

 Loosen restrictive
 clothing.

 Remove eye glasses.

 Clear the area.

 Do not restrain the
 child.

 Monitor for status Status epilepticus
 epilepticus. is an emergency, and
 the physician should
 be notified.

Risk for Do not give foods or Swallowing reflex
aspiration fluids during may be lost with an
 seizure. increase in
 salivation;
 In the event of therefore, airway
 emesis, turn child management and
 on side. prevention of
 aspiration are
 Provide postictal essential.
 oral care.

Urinary Teach intermittent Residual urine in
retention catheterization the bladder is a
 technique. medium for bacterial
 growth. Neurogenic
 Educate parents bladder can be
 regarding symptoms manifested as
 of urinary tract urinary retention
 infection and with potential for
 bladder palpation urinary tract
 techniques. infection.

 Monitor urinary
 output.

Constipation Promote adequate Fluid intake between
 fluid intake. 30 and 40 ml/kg of
 body weight per day
 is recommended.

 Adjust fiber intake Minimum fiber intake
 to maintain stool of 18 g daily should
 consistency. (Fiber be adjusted to
 can be available in maintain stool
 formula.) consistency.

 Educate regarding These agents assist
 bulk forming or with moving stool
 osmotic laxatives as through the bowel.
 well as stool
 softeners.

 Administer Suppositories and
 suppositories or enemas are effective
 enemas as needed. in achieving bowel
 evacuation.

 Educate parents to Neurogenic bowel can
 monitor the be manifested as
 frequency, constipation, and
 consistency, and education is needed
 characteristics of regarding monitoring
 the stool. the characteristics
 of the stool.

Impaired Teach transfer Children with
physical techniques to the impaired physical
mobility child and parents. mobility often
 require assistance
 with transfer.

 Teach lifting Teaching proper
 techniques. techniques for
 lifting and transfer
 is necessary for the
 safety 3 of the
 child and caregiver.

 Perform regular Position changes
 position changes at must be performed to
 least every 2 hours. prevent skin
 breakdown and
 promote oxygenation.

 Perform Range of motion is
 active-passive range performed to promote
 of motion. joint mobility.

 Teach to assess for Parents should be
 skin integrity, taught to assess for
 edema, peripheral complications of
 circulation, and impaired physical
 oxygenation. mobility.

TABLE 3. Antiepileptic Drugs (Abrams, Pennington, &
Lammon, 2007; Deray, Resnick, & Alvarez, 2004;
Jarrar & Buchhalter, 2003; Wilson, Shannon,
Shields, & Stang, 2007)

Drug Seizure Adverse Effects Remarks
 Classification

Felbamate Monotherapy or Insomnia, Elimination is
 adjuvant anorexia, via the hepatic
 therapy for weight loss, and renal
 adults with nausea, system; may
 refractory vomiting, gait increase serum
 partial disturbances, levels of
 seizures; aplastic phenytoin,
 adjuvant anemia, phenobarbital,
 therapy for hepatotoxicity carbamazepine,
 partial or and valproic
 generalized acid; status
 seizures in epilepticus may
 children occur with
 sudden
 withdrawal
 of felbamate

Gabapentin Partial (with Few adverse Renal
 or without effects but may excretion;
 secondary include administer
 generalization) aggression, three to four
 hyperactivity, times a day;
 fatigue, can be used in
 ataxia, combination
 nystagmus, and therapy
 weight gain

Lamotrigine Partial and Rash, including Development of
 generalized the rash of rash is more
 seizures in Stevens-Johnson likely in
 adults; syndrome, combination
 juvenile dizziness, therapy with
 myoclonic diplopia, valproic acid,
 seizures, ataxia, if the initial
 typical and headache, doses of
 atypical blurred vision, Lamotrigine are
 absence nausea, large, or if
 seizures vomiting, and the titration
 somnolence of the drug is
 rapid;
 immediate
 discontinuation
 if rash
 develops;
 metabolized in
 the liver

Levetiracetam Add-on therapy Somnolence, Primarily
 for partial lack of excreted via
 seizures in coordination, the kidneys;
 adults transient metabolized by
 leukopenia, the liver
 agitation,
 anxiety,
 emotional
 lability,
 headache

Oxcarbazepine Monotherapy and Dizziness, May increase
 adjuvant drowsiness, serum levels of
 therapy for diplopia, phenytoin and
 partial nausea, ataxia, phenobarbital;
 seizures in allergic rashes hepatic
 adults and metabolism
 adjuvant
 therapy for
 partial
 seizures in
 children

Tiagabine Partial Somnolence, Can be used as
 seizures in dizziness, monotherapy or
 adults and headache combination
 children over therapy;
 12 years old metabolized in
 the liver

Topiramate Adjuvant Highly prone to May increase
 therapy for cause adverse phenytoin
 adults and effects levels and
 children over including increase oral
 years old 2 nephrolithiasis, contraceptive
 with partial fatigue, a elimination;
 seizures or decrease in titrate slowly;
 primary appetite, use cautiously
 generalized weight loss, in patients
 tonic-clonic somnolence, with kidney
 seizures dizziness, stones;
 headache, encourage
 diplopia, increased fluid
 speech intake to
 difficulties, prevent
 nystagmus, nephrolithiasis;
 paresthesia, hepatic and
 confusion renal
 elimination

Vigabatrin Not currently Visual field Renal
 approved for constriction elimination;
 use in the (this adverse drug must be
 United States; effect is the ordered from
 monotherapy and cause of the Canada, Mexico,
 add-on therapy limited use); European
 for adults with hyperactivity, countries,
 partial drowsiness, etc., and
 seizures; wide ataxia, delivery may be
 variety of insomnia, delayed due to
 pediatric stupor, coming through
 seizure somnolence customs; must
 syndromes teach caregiver
 to order an
 adequate supply
 as soon as it
 is possible to
 reorder so
 there is no
 interruption in
 the supply of
 the drug due to
 delayed
 delivery

Zonisamide Adjuvant Stevens-Johnson Can be used as
 therapy for syndrome, monotherapy;
 partial nephrolithiasis, metabolized in
 seizures in drowsiness, the liver;
 patient 16 ataxia, hepatic and
 years or older anorexia, renal
 headache, elimination;
 gastrointestinal adverse effects
 discomfort, tend to occur
 rash, pruritis early in the
 course of
 therapy

Carbamazepine Partial, Muscle cramps, Metabolized in
 generalized, syncope, the liver to an
 tonic-clonic, anorexia, active
 and mixed abnormal liver metabolite;
 seizures function tests, induces its own
 drowsiness, metabolism,
 confusion monitor CBC,
 electrolytes,
 and liver
 function tests;
 discontinue MAO
 inhibitors 14
 days prior to
 treatment with
 Carbamazepine

Clonazepam Adjuvant or Dry mouth, Schedule IV
 monotherapy in drowsiness, drug;
 generalized ataxia, monotherapy or
 seizures, respiratory combination
 partial depression, therapy;
 seizures in confusion, monitor liver
 adults and muscle cramps function tests;
 children tolerance to
 anti-seizure
 effects may
 develop with
 long-term use

Ethosuximide Absence Drowsiness, Eliminated by
 seizures, sleep hepatic
 possibly disturbances, metabolism
 myoclonic anorexia,
 seizures weight loss,
 gingival
 hyperplasia

Phenytoin General Ataxia, Prototype drug,
 tonic-clonic drowsiness, oral care is
 and partial lethargy, important,
 nausea, monitor
 vomiting, phenytoin
 osteoporosis, levels,
 gingival encourage
 hyperplasia Vitamin D
 foods, may
 change urine
 color

Phenobarbital Generalized Sedation, Long acting
 tonic-clonic hypotension, barbiturate;
 and partial respiratory takes 3 to 4
 seizures depression, weeks to
 gastrointestinal achieve steady
 disturbances state;
 metabolized in
 the liver;
 accelerates
 metabolism of
 other drugs due
 to liver enzyme
 induction

Valproic acid Absence, mixed, Hepatotoxicity, Patient may
(valproate) and complex pancreatitis, have
 partial sedation, breakthrough
 seizures Acute anorexia, seizures;
 convulsive prolonged cannot be given
 seizures; bleeding time, intravenously;
Diazepam status photo- monitor liver
 epilepticus sensitivity, function tests,
 increased also used for
 appetite with bipolar
 weight gain disorder;
 Drowsiness, metabolized in
 hypotension, the liver,
 tachycardia, excreted by the
 hepatic kidney 9
 dysfunction, Schedule IV
 respiratory drug; can be
 depression given rectally
 and
 intravenously
 as well as
 orally; monitor
 liver function
 tests

Lorazepam Acute Drowsiness, Schedule IV
 convulsive sedation, drug; drug of
 seizures; gastrointestinal choice with
 status disturbances, status
 epilepticus respiratory epilepticus;
 depression can be given
 intranasally,
 intravenously,
 or orally

Midazolam Acute Headache, Schedule IV
 convulsive drowsiness, drug, can be
 seizures; sedation, given
 status respiratory intravenously,
 epilepticus depression intranasally,
 or per buccal
 mucosa

TABLE 4. Teaching Points Related to
Antiepileptic Drug Therapy
(Fagley, 2007)

Administer as prescribed.

Maintain a diary of seizure activity to monitor the drug's
therapeutic effect.

Monitor for adverse effects.

Obtain drug blood levels as ordered.

Never abruptly discontinue the medication without
healthcare professional consent.

Schedule follow-up appointments.

Keep an extra supply of medication on hand to avoid an
accidental lapse.

TABLE 5. Alternative Methods of Seizure
Management (Freeman, Freeman, & Kelly, 2000;
Hemingway, Freeman, Pillas, & Pyzik, 2001;
Jarrar & Buchhalter, 2003; Farooqui, Boswell,
Hemphill, & Pearlman, 2001)

Therapy Description Remarks

Ketogenic Ketotic state Exact mechanism
diet initiated with is unknown.
 a diet high in
 fat (3 to 4 Child is said
 parts) and low to be ketotic
 in carbohydrate when urinalysis
 and protein (1 shows ketones.
 part) Absence
 of Ketones exhaled
 carbohydrates by the lungs
 leads to produce a sweet
 metabolism of smell to the
 fats and breath.
 formation of
 ketone bodies. Potential risk
 for kidney
 stones exists.

 Enteral
 formulas are
 available.

Vagus Device with (a) Thought to
nerve pulse generator interfere with
stimulator which is neuronal
 implanted in discharge with
 the chest wall results of
 and (b) increasing
 electrode which seizure
 wraps around threshold,
 left vagus exciting
 nerve inhibitory
 pathways, and
 releasing
 inhibitory
 neurotransmitters.

 Stimulates May decrease
 vagus nerve at number of
 preset seizures or
 intervals and duration and
 intensity. intensity
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Author:Turkelson, Sandra L.; Martin, Caron
Publication:Journal of Neuroscience Nursing
Article Type:Report
Geographic Code:1USA
Date:Oct 1, 2009
Words:6230
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