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Magnetic Modification of Cells Surface Made Possible by Magnetic Nanoparticles.

Summary: TEHRAN (FNA)- The researchers at Iran's Tarbiat Modares University managed to modify cells surfaces and biomolecules magnetically via achieving magnetic nanoparticles bonding technology.

"We used flavobacterium which produces organophosphorus hydrolase (OPH) as a model to modify cells and biomolecules magnetically", Seyed Morteza Robatjazi, PhD student of chemical engineering-biotechnology, said in an interview with the INIC.

"We managed to produce magnetized flavobacterium by keeping more than 90% of enzymatic activity," he added.

The researchers investigated covalent and absorptive reaction between super paramagnetic and bacteria cells completely and optimized important parameters related to this reaction.

According to the researcher, they managed to increase the stability of bacterial enzymatic activity by stabilization process of magnetically modified bacteria through magnetic field. They also stabilized cells by magnetic method and used it for the removal of organophosphate compounds.

The stabilization of cells, dead or alive, results in increasing enzymatic activity and its stability time. The growth rate, maintenance and efficiency of viable cells are increased by their stabilization. A new and useful method for stabilizing the cells is to use magnetic field. However, most of cells are diamagnetic and don't respond to magnetic field considerably. So, the surface cells have to be magnetically modified.

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Publication:FARS News Agency
Date:Mar 10, 2011
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