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MIRNA MICROARRAYS FEATURES MIRBASE 21 CONTENT.

Agilent Technologies Inc. has updated its SurePrint miRNA Microarrays to include targets from the latest public miRNA miRBase database. The database, miRBase 21, contains 28,645 entries, including more than 15 percent in content added from miRBase 20.

Agilent SurePrint miRNA Microarrays feature innovative labeling and hairpin probe designs to provide exceptional sequence and size discrimination.

MicroRNA, or miRNA, research has grown dramatically in the effort to better understand gene regulation in diseases, such as cancer. The availability of Agilent SurePrint human, mouse and rat miRNA microarrays, with miRBase 21 targets, provides pre-designed microarrays for the most commonly studied models. Any species in the miRBase database can also be used to create a custom microarray through the Web-based design tool eArray to include probe content from the latest miRBase 21.

In a recently published miRQC study1, Agilent SurePrint miRNA Microarrays were compared with various qPCR, next- generation sequencing, and microarray platforms to benchmark performance. Starting with only 100 ng of total RNA, Agilent miRNA microarrays exhibited excellent performance with the highest titration response, reproducibility and precision in accuracy while requiring the lowest sample amount among the next-closest performing assays.

Providing the latest content, easy customizability and superior performance in our miRNA microarrays reinforces the merits of our SurePrint technology, said Alessandro Borsatti, senior director of Marketing for Agilent's Diagnostics and Genomics group. We maintain our commitment to microarrays because they provide well-proven and established workflows for scientists seeking the greatest efficiency and cost-effectiveness for investigating miRNAs.

SurePrint miRNA Microarrays are part of the SurePrint product family, including gene expression and comparative genomic hybridization (CGH) microarrays. The breadth of microarray applications is enhanced by the depth of Agilent's genomic workflowfrom the 2100 Bioanalyzer and 2200 TapeStation for QC, to SureScan Scanner for data acquisition, GeneSpring for data analysis and AriaMX system for Real-Time PCRto provide researchers a complete solution.

For more information about SurePrint miRNA Microarrays, visit www.agilent.com/genomics/miRNA21.

About Agilent in Genomics

Agilent is a global leader in target enrichment for next- generation sequencing and genomic microarrays. The Agilent SureSelect and HaloPlex target-enrichment systems enable researchers to easily choose which segments of a genome to sequence, avoiding the time and expense needed to sequence the entire genome. HaloPlex offers a same-day sample-to- sequencer workflow; SureSelect can accurately capture whole exomes and whole methylomes in a single reaction. These are just two products arising from Agilent's expertise in synthesizing custom complex mixtures of long oligonucleotides gained in microarray manufacturing. Additional product lines built on this core technology include microarrays for genome-wide measurement of gene expression and for comparative genomics hybridization, as well as SureFISH, a highly specific and sensitive product line for oligonucleotide fluorescent in situ hybridization. In addition to oligonucleotide-based products, Agilent offers a microfluidic bioanalyzer to measure sample quality, and a full set of reagents, hardware, methods and bioinformatics software for genomic experiments.

For more information on Agilent's complete line of Genomics solutions, visit: www.chem.agilent.com/en- US/Solutions/Genomics/Pages/default.aspx.

About Agilent Technologies

Agilent Technologies Inc. (NYSE:A) is a provider of chemical analysis, life sciences, diagnostics, electronics and communications. The company's 20,600 employees serve customers in more than 100 countries. Agilent had revenues of $6.8 billion in fiscal 2013. Agilent has announced plans to separate into two publicly traded companies through a tax-free spinoff of its electronic measurement business.

For more information, visit www.agilent.com or call 408/553-7093.
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Publication:Worldwide Databases
Date:Nov 1, 2014
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