Lung Adenocarcinoma Presented with Extensive Pulmonary Calcification.
Calcification in lung lesions usually indicates a benign course, especially when the pattern of calcium deposition is of the popcorn, diffuse, laminated, or central type (1). Radiological visualization of extensive calcification in bronchogenic carcinoma is not familiar and may cause confusion and misdiagnosis; (2) however; it may be rarely seen and has also been reported (3).
A 71-year-old female patient complained of exertional dyspnea and dry cough for one year. CT chest showed right-side pleural effusion with underlying lung calcification (Fig. 1). Tuberculin skin test was negative. Pleural fluid aspiration was serosanginous and exudative. Transthoracic ultrasonography was performed and revealed right massive complex nonseptated pleural effusion, no pleural thickening or nodulation, and a hyperechogenic collapsed lung that favored the presence of calcification (Fig. 2). Pleural fluid cytology revealed atypical cells with adenocarcinoma. The patient underwent bronchoscopy to confirm the diagnosis of malignancy, and the lateral wall of the intermediate bronchus of the right bronchial tree was infiltrated by multiple nodules. It was also circumferentially narrowed. The bronchoscope could not be introduced inside it. Multiple biopsies were obtained from the mucosa of intermediate bronchus for histopathology (Fig. 3), which revealed malignant glandular structures with mucin secretion. Also, solid clusters of atypical cells mixed with scattered psammomatous-like calcification were seen and confirmed the diagnosis of mucinous moderately differentiated adenocarcinoma (Fig. 4).
Lung carcinoma is often diagnosed late and varies widely in symptoms, pathology, and prognosis (4). Lung adenocarcinoma is often seen in nonsmokers and females (5). It commonly presents as ill-defined lung nodules in chest radiography and can be usually confused with atypical infections (6, 7).
The extent and distribution of calcification are important factors while assessing a solitary pulmonary nodule; however, this is difficult and confusing. Central, solid, and laminated forms of calcification are specific to previous granulomatous infection, such as a tuberculous infection. Popcorn calcification indicates cartilage component in the nodule (e.g., hamartoma and cartilage tumors). Eccentric calcification can present as a calcified granuloma engulfed by a malignancy or a dystrophic malignant calcification (13). Literature reviews have revealed that reported cases of calcified lung cancer are still uncommon (8).
Calcification within lung cancer occurs by the following mechanisms: (A) calcified scars or granuloma engulfed by a tumor, (B) dystrophic calcification in the necrotic parts of tumor, and (C) calcium deposition by the secretory function of carcinoma itself (e.g., mucinous adenocarcinoma) as in our case (1, 9). Histologically, Psammoma bodies are uncommon in lung adenocarcinoma. Interestingly, this predicts a good response to tyrosine kinase inhibitors (10).
Lung calcification is not easy to interpret and may cause confusion. Detection of underlying disease should not be taken lightly. Although extensive lung calcification is rare in lung malignancy, it should be considered in the differential diagnosis.
Informed Consent: Written informed consent was obtained from patients who participated in this study.
Peer-review: Externally peer-reviewed.
Author Contributions: Conceived and designed the experiments or case: AOS. Performed the experiments or case: KMK, SAH. Analyzed the data: AAH, HA. Wrote the paper: MSM, HGY. All authors have read and approved the final manuscript.
Conflict of Interest: The authors have no conflict of interest to declare.
Financial Disclosure: The authors declared that this study has received no financial support.
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Alaa Omar Shalaby [iD], Khaled Mahmoud Kamel [iD], Ahmed Al Halfawy [iD], Hassan Amin [iD], Sabah Ahmed Hussein [iD], Hassan Gamal Yamamah [iD], Mohamed Shaaban Mousa [iD]
Cite this article as: Shalaby AO, Kamel KM, Al Halfawy A, Amin H, Hussein SA, Yamamah HG, et al. Lung Adenocarcinoma Presented with Extensive Pulmonary Calcification. Erciyes Med J 2019; 41(1): 114-6.
Department of Chest diseases, Cairo University Faculty of Medicine, Egypt
Available Online Date 12.02.2019
Correspondence Mohamed Shaaban Mousa, Department of Chest diseases, Cairo University Faculty of Medicine, Egypt
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|Title Annotation:||CASE REPORT|
|Author:||Shalaby, Alaa Omar; Kamel, Khaled Mahmoud; Halfawy, Ahmed Al; Amin, Hassan; Hussein, Sabah Ahmed; Ya|
|Publication:||Erciyes Medical Journal|
|Article Type:||Case study|
|Date:||Mar 1, 2019|
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