Lofexidine: An option for treating opioid withdrawal.
How to prescribe lofexidine
For decades, clinicians in Britain have prescribed lofexidine to attenuate opioid withdrawal. (1) An analog of clonidine, lofexidine is reportedly less likely than clonidine to induce hypotension. (1,4) While this agent does not diminish drug toxicity, it can provide symptomatic relief for patients undergoing opioid withdrawal, and is efficacious as a supplement to and/or replacement for methadone, buprenorphine, clonidine, or other symptomatic pharmacotherapies. (1,4,5)
Lofexidine is available in 0.18-mg tablets. For patients experiencing overt symptoms of opioid withdrawal, initially prescribe 3 0.18-mg tablets, 4 times a day. (3) The recommended maximum dosage is 2.88 mg/d, and each dose generally should not exceed 0.72 mg/d. Lofexidine may be continued for up to 14 days, with dosing guided by symptoms. Initiate a taper once the patient no longer experiences withdrawal symptoms. (3)
Adverse effects. Lofexidine's efficacy and safety were evaluated in 3 randomized, double-blind, placebo-controlled trials that included 935 participants dependent on short-acting opioids who were experiencing abrupt opioid withdrawal and received lofexidine, 2.16 or 2.88 mg/d, or placebo. (3) The most common adverse effects of lofexidine were insomnia, orthostatic hypotension, bradycardia, hypotension, dizziness, somnolence, sedation, and dry mouth. (3) In the 3 trials, these effects were reported by [greater than or equal to] 10% of patients receiving lofexidine, and occurred more frequently compared with placebo (Table, (3) page 31).
Take precautions when prescribing lofexidine because it can cause QT prolongation and CNS depression, especially when co-administered with sedative agents. (3) It also can result in rebound hypertension once discontinued. This may be minimized by gradually reducing the dosage. (3)
A pathway to OUD treatment
Lofexidine can help relieve symptoms of opioid withdrawal, such as stomach cramps, muscle spasms or twitching, feeling cold, muscular tension, and aches and pains. (1-5) This new option might help clinians encourage more patients with OUD to fully engage in substance abuse treatment.
Dr. Sultana is a Research Scholar, Department of Internal Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
Dr. Doifode is an Observer Physician, Department of Psychiatry, University of Louisville School of Medicine, Louisville. Dr. Lippmann is Emeritus Professor, Department of Psychiatry, University of Louisville School of Medicine, Louisville.
The authors report no financial relationships with any companies whose products are mentioned in this article, or with manufacturers of competing products.
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(1.) Rehman SU, Maqsood MH, Bajwa H, et al. Clinical efficacy and safety profile of lofexidine hydrochloride in treating opioid withdrawal symptoms: a review of literature. Cureus. 2019;11(6):e4827. doi: 10.7759/cureus.4827.
(2.) FDA approves the first non-opioid treatment for management of opioid withdrawal symptoms in adults. US Food & Drug Administration, https://www.fda.gov/ newsevents/newsroom/pressannouncements/ucm607884 htm. Published May 16, 2018. Accessed December 13, 2019.
(3.) Lucemyra [package insert]. Louisville, KY: US WorldMeds LLC; 2018.
(4.) Camwath T, Hardman J. Randomized double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal. Drug Alcohol Depend 1998;50(3):251-254.
(5.) Gonzalez G, Oliveto A, Kosten TR. Combating opiati dependence: a comparison among the availabl pharmacological options. Exp Opin Pharmacother. 2004 5(4):713-725.
Table Lofexidine-induced adverse effects Lofexidine, Treatment 2.88 mg/d Lofexidine, Adverse effect (n = 222) 2.16 mg/d Placebo (n = 229) (n = 151) Insomnia 55% 51% 48% Orthostasis 42% 29% 5% Bradycardia 32% 24% 5% Hypotension 30% 30% 1% Dizziness 23% 19% 3% Somnolence 13% 11% 5% Sedation 12% 13% 5% Xerostomia 11% 10% 0% Source: Reference 3
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|Author:||Sultana, Tallat; Doifode, Tejaswini; Lippmann, Steven|
|Date:||Jan 1, 2020|
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