Printer Friendly

Liver transplant transfers peanut allergy.

After eating a meal with satay sauce in a Paris restaurant, a 22-year-old man who is allergic to peanuts suffers cardiac arrest, falls into a coma, and is diagnosed as brain dead.

Being an organ donor, his liver and one kidney are transplanted into a 35-year-old man, who then recovers. The donor's pancreas and other kidney go to a 27-year-old woman, who also rebounds.

Three months later, however, the male recipient--who has no previous allergy to peanuts--breaks out in a rash after eating some of these legumes. Doctors treat him and then contact the woman, who reports no such episodes. Under close medical supervision, she eats some peanuts. Nothing happens.

This strange case, reported in the Sept. 18 New England Journal of Medicine, appears to be the first documented instance of a transplanted organ that imparted an allergy to its recipient. In earlier studies, transplanted bone marrow has been shown to transfer some allergies, apparently because bone marrow is rich in hematopoietic stem cells--immature cells whose daughters grow into red and white blood cells.

The new case draws attention to the liver, another source of these stem cells. The allergic reaction indicates a blending of the donor and recipient immune systems, the researchers suggest. Tests showed that donor-derived cells migrated from the liver to the recipient's skin and were working in league with his own immune system to form the rash.

Other tests solidified the immune system connection. Peanut-specific antibodies, which were plentiful in the blood of the dead man and absent from the recipient at the time of the operation, turned up in the recipient later, says study coauthor Christophe Legendre of St. Louis Hospital in Paris.

Some of the donor's lymphocytes, white blood cells that defend against intruders in the body, had been activated by peanuts, Legendre says. Among the lymphocytes are two types of B cells, plasma cells and memory cells. Plasma cells produce antibodies to fight the perceived enemy, while memory cells mainly take note of the situation. When later exposed to the same antigen--in this case, peanuts--the memory cells create more plasma cells to do battle.

The donor's peanut-specific memory cells may have induced the recipient's plasma cells to produce antibodies that react to peanuts, Legendre says. An antibody called immunoglobulin E causes allergic reactions by stimulating cells to churn out histamines and other inflammatory agents.

Despite the new finding, transplant recipients need not worry about dangerous allergies, says J. Harold Helderman, an immunologist at Vanderbilt University Medical Center in Nashville and president of the American Society of Transplant Physicians. The result in this case, he notes, was a skin rash, not a systemic, life-threatening reaction. Thousands of patients have received livers without developing allergies.

More important, he says, the study sheds light on the debate over microchimerism, the theory that immune cells from a donor eventually work alongside those of the recipient and perhaps mitigate rejection. Doctors disagree on how much immune system suppression is needed after a transplant. In rare cases, recipients have been taken off suppressant drugs and done fine, Legendre says. "This happens to be another piece of evidence that the concept of microchimerism is valid," Helderman says.

The finding also highlights the peculiarity of the peanut allergy (SN: 5/4/96, p. 279), which is associated with a high risk of death, says Marshall Plaut of the National Institute of Allergy and Infectious Diseases in Bethesda, Md.
COPYRIGHT 1997 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1997, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Author:Seppa, Nathan
Publication:Science News
Date:Sep 20, 1997
Words:567
Previous Article:Tinier transistors for tomorrow's chips.
Next Article:Signs of ancient life in deep, dark rock.
Topics:


Related Articles
Herpes virus transplanted with organs?
Human immune system implanted in mice.
New way of keeping donor livers healthy.
Liver-transplant surgeons use living donor.
Organs spread hepatitis C.
Organ allocation should be an equal-opportunity procedure.
Organ grinders.
Societal Attitudes and Alcohol Dependency: The Impact on Liver Transplantation Policy.
SUR9 Heart-lung-liver transplant for cystic fibrosis. (Surgery).
Critical transfer: brokers should advise self-insured clients to carve out organ-transplant coverage to keep medical-benefits costs healthy.

Terms of use | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters