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Link between Folate Intake and Cleft Palate unlikely.

A recent study, "Folate and Clefts of the Lip and Palate," shows that the possible link between expecting women taking multivitamin supplements with folate and the decreased incidence of cleft lip and/or palate is weaker than previously thought.

Although studies about this link performed with animals have had positive outcomes, due to the difficulty in separating the effects of folate in combination with other nutrients in the body and differences between various studies and statistics, results in humans are less definite.

Researchers led by Julian Little, PhD, conducted the population-based case-control study involving almost 500 infants. Numerous measures of folate status and comprehensive evaluations of confounding factors led the researchers to determine that there was no relationship between incidence of orofacial cleft and supplemental or dietary folic acid.

They found that although it is possible that other aspects relating to the intake of folio acid may have a part in the occurrence of cleft lip or palate, increased folate ingestion did not prevent or reduce this occurrence.

According to the Cleft Palate Foundation, cleft lip and/or palate are among the most common birth defects in the United States, affecting almost 7,000 children per year, or one in every 600 newborns.

Source: American Cleft Palate-Craniofacial Association

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Title Annotation:health
Article Type:Brief article
Geographic Code:1USA
Date:Nov 1, 2008
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