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Limited ethanol teratogenic effects in NSA mice.

Prenatal alcohol exposure is known to cause both pre--and postnatal growth deficiency, malformations, and behavioral deficits. Evidence in both humans and animals suggest genetic factors are important in determining the severity of these effects. Our research using mice shows that some stocks exhibit a range of effects that include fetal weight deficits, malformations of the vertebral column and kidneys, and increased prenatal mortality. However, very few mouse stocks have been examined. In this experiment we examine ethanol teratogenesis in NSA mice by exposing pregnant dams to either 5.8 g/kg ethanol or an isocaloric amount of maltose-dextrin on day 9 of pregnancy. Litters were assessed for skeletal and soft-tissue malformations, weight deficits, and increased mortality. In no instance did we find an effect of prenatal alcohol exposure. NSA mice are among the few mouse stocks known to be resistant to ethanol teratogenesis.

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Author:Deganhart, Nick; Hart, Jeremy; Gilliam, David
Publication:Journal of the Colorado-Wyoming Academy of Science
Article Type:Brief Article
Geographic Code:1USA
Date:Apr 1, 2002
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