Limited ethanol teratogenic effects in NSA mice.
Prenatal alcohol exposure is known to cause both pre--and postnatal growth deficiency, malformations, and behavioral deficits. Evidence in
both humans and animals suggest genetic factors are important in
determining the severity of these effects. Our research using mice shows
that some stocks exhibit a range of effects that include fetal weight
deficits, malformations of the vertebral column and kidneys, and
increased prenatal mortality. However, very few mouse stocks have been
examined. In this experiment we examine ethanol teratogenesis in NSA mice by exposing pregnant dams to either 5.8 g/kg ethanol or an
isocaloric amount of maltose-dextrin on day 9 of pregnancy. Litters were
assessed for skeletal and soft-tissue malformations, weight deficits,
and increased mortality. In no instance did we find an effect of
prenatal alcohol exposure. NSA mice are among the few mouse stocks known
to be resistant to ethanol teratogenesis.
* Denotes membership in the Colorado-Wyoming Academy of Science.