Printer Friendly

Letter on the problems associated with CRISPR-mediated gene editing. Cruelty Fee INTERNATIONAL: Ending animal experiments worldwide.

Trends in Biotechnology has published a letter by Dr Jarrod Bailey, Senior Research Scientist at Cruelty Free International, which summarizes the many scientific and ethical issues with the use of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic modification (GM) (Bailey, 2019).

The CRISPR technique is becoming an increasingly popular tool for gene editing because it is an inexpensive, relatively simple and quick way of producing GM animals. It has also been claimed to not only be more accurate than traditional methods but to actually help reduce animal numbers (because it is so accurate that fewer animals might be wasted). However, there remains substantial evidence to warrant great concern over the poor efficiency of CRISPR. In his Letter, Dr Bailey argues that there is evidence that the efficiency of CRISPR to "knock-in" a particular gene in an animal is less than 4%, while the efficiency to "knock-out" a gene is around 7%. Furthermore, it appears that CRISPR introduces unwanted or "off-target" mutations and while the degree is open to question, these unintended genetic modifications can have serious consequences for animal welfare and wastage.

COPYRIGHT 2019 Springer Spektrum
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2019 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:ALTEX: Alternatives to Animal Experimentation
Date:Jun 22, 2019
Words:184
Previous Article:HEARTS Act introduced to prioritize the use of non-animal methods in US NIH funded research. Cruelty Fee INTERNATIONAL: Ending animal experiments...
Next Article:BCLAS symposium on non-technical summaries. Cruelty Fee INTERNATIONAL: Ending animal experiments worldwide.
Topics:

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters