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Kids getting umbilical cord blood instead of BMT from HLA-identical siblings have lower GVHD.

Children who received umbilical cord blood transplants from HLA-identical siblings had a lower incidence of acute and chronic graft-versus-host disease (GVHD) than youngsters given bone marrow transplants (BMT) from HLA-identical siblings, according to an international study published in the June 22 issue of the New England Journal of Medicine.

Overall survival in this registry study of 113 cord blood recipients and 2,052 BMT recipients during the period from 1990 through 1997 did not differ significantly between the 2 groups, however, regardless of the indication for transplantation and despite a slower rate of engraftment after cord blood transplant.

"These results justify the systematic collection of cord blood in families with a child affected by a disease that can be treated successfully by allogeneic transplantation of hematopoietic stem cells," wrote Vanderson Rocha, MD and colleagues from the Eurocord-Cord Blood Transplant Group. "The results also support further exploration of cord blood as a source of stem cells for transplants from unrelated donors."
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Comment:Kids getting umbilical cord blood instead of BMT from HLA-identical siblings have lower GVHD.
Publication:Transplant News
Article Type:Brief Article
Geographic Code:1USA
Date:Jun 30, 2000
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