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Investigation of Canine-Mediated Human Rabies Death, Haiti, 2015.

Haiti is one of the few countries in the Western Hemisphere where canine rabies control has not successfully eliminated canine-mediated human rabies deaths (7). During 2010-2012, an average of 4 canine and 7 human rabies cases were reported annually in Haiti; however, this rate is widely recognized as an underestimate of the true burden (2-4).

On September 22, 2015, public health officials of Haiti requested assistance with the investigation of a suspected human rabies death in Platfon, a rural part (human population 769) of the Gonaives Arrondissement. The case involved a 4-year-old girl who was bitten on the stomach by a dog 3 months before the onset of illness in late August. She had clinical symptoms consistent with rabies before death: hydrophobia, agitation, and localized paralysis. The child was not taken to the hospital for treatment after the bite or during her illness and died at home on September 8. In response to this probable human rabies case (according to the World Health Organization case definition) (1) and reports of increased rabies-like illnesses among dogs in the community, an international multiagency team was assembled to identify potential additional persons bitten for postexposure prophylaxis, conduct a dog vaccination campaign, and characterize healthcare-seeking and dog ownership behaviors.

We identified 4 additional persons bitten by the same dog responsible for the initial probable rabies case. During the investigation, community members requested the team investigate 2 additional events of suspected rabies transmission. The first event involved 10 persons bitten by a dog in the city of Gonaives (Figure, panel A). Brain samples from the dog were laboratory-confirmed positive for rabies virus. The second event involved 3 persons bitten by a dog, 1 of which subsequently died in July. In total, 2 probable human rabies deaths and 16 bitten persons were identified during the 3-week investigation (Figure, panel B). Although educational outreach and postexposure prophylaxis were offered at no cost to all persons bitten, 25% (n = 4) refused vaccination because of religious beliefs. Their current health status is unknown.

We surveyed 82 dog owners (mean 35.6 [range 18-60] years of age) attending the canine vaccination campaigns in Platfon and the city of Gonaives. The owners reported that 24 (4.3%) of 559 persons living in their households (median persons/household 6.9), including themselves, were bitten by dogs within the past year. Although 70% of survey respondents were aware that rabies can be transmitted through animal bites, only 53% knew that these bites could result in death. Approximately 83% of respondents stated they would seek medical care after an exposure but reported barriers to obtaining treatment: financial obstacles associated with transportation and treatment (47%) and absence of a local medical facility and trained personnel in the community (28%). Respondents stated it took 29 (range 5-180) minutes on average to travel to the nearest medical facility.

We also conducted animal health screenings during the vaccination campaign and estimated the local dog population (5 to assess vaccination coverage level. No animals were exhibiting signs consistent with rabies at the time of the investigation. A 2-day count identified 41 dogs, 21 of which had evidence of vaccination from our campaign (51.2% coverage). We estimated 87 dogs in this community and a 9:1 human-to-dog ratio, which is more similar to the ratio in Africa than Latin America, where the human-to-dog ratio is lower (6,7). Dog owners reported this was the first mass vaccination campaign available to them in the past 5 years. Given Platfon's remoteness, we believe many of these dogs were never vaccinated before this response.

Our investigation indicates that the rabies burden in Haiti is much greater than detected through passive surveillance because of the lack of healthcare-seeking behavior among persons bitten by dogs. We estimate the rabies-associated mortality rate as 0.67 cases/100,000 population, which is much higher than Haiti's health facility-based surveillance system estimates (average 0.07 cases/100,000 population) (2-4,8). The 2 probable human rabies cases and 16 persons bitten identified in this study were not originally reported to health officials because they did not seek care for their exposures and, thereby, were not captured in the national surveillance system.

Furthermore, this underreporting negatively affects proper allocation and stockpiling of nationally procured rabies biologics for animals. Intermittent dog vaccination campaigns are insufficient to break the cycle of rabies transmission. Sustained campaigns targeting 70%-80% of the dog population will be necessary to eliminate canine rabies (1,9). Anecdotal evidence suggests that social mobilization campaigns to increase healthcare-seeking behavior might be effective; most of the cases investigated in our study were reported by a community member in Platfon who alerted health officials after attending a rabies educator's workshop. We hope these findings will prompt a discussion for improvements in rabies prevention and control measures that empower community members with knowledge to notify officials of suspected rabies transmission events.

Acknowledgments

We thank the families for allowing us to share this investigation and the staff at the Ministere de l'Agriculture, des Resources Naturelles et du Developpement Rural and other collaborating institutions for their continuous support and their commitment to rabies elimination.

Dr. Tran is an epidemiologist for the Poxvirus and Rabies Branch, High-Consequence Pathogens and Pathology Division, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Her interests include vaccine-preventable diseases, community-based initiatives, and implementation science.

References

(1.) World Health Organization. WHO expert consultation on rabies. Second report. World Health Organ Tech Rep Ser. 2013;982:1-139.

(2.) Vigilato MA, Clavijo A, Knobl T, Silva HM, Cosivi O, Schneider MC, et al. Progress towards eliminating canine rabies: policies and perspectives from Latin America and the Caribbean. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120143. http://dx.doi.org/10.1098/rstb.2012.0143

(3.) Vigilato MA, Cosivi O, Knobl T, Clavijo A, Silva HM. Rabies update for Latin America and the Caribbean. Emerg Infect Dis. 2013;19:678-9. http://dx.doi.org/10.3201/eid1904.121482

(4.) Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al.; Global Alliance for Rabies Control Partners for Rabies Prevention. Estimating the global burden of endemic canine rabies. [Erratum in: PloS Negl Trop Dis. 2015;e0003786.] PLoS Negl Trop Dis. 2015;9:e0003709. http://dx.doi.org/10.1371/journal. pntd.0003709

(5.) Tenzin T, McKenzie JS, Vanderstichel R, Rai BD, Rinzin K, Tshering Y, et al. Comparison of mark-resight methods to estimate abundance and rabies vaccination coverage of free-roaming dogs in two urban areas of south Bhutan. Prev Vet Med. 2015;118:436-48. http://dx.doi.org/10.1016/j.prevetmed.2015.01.008

(6.) Knobel DL, Cleaveland S, Coleman PG, Fevre EM, Meltzer MI, Miranda ME, et al. Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005;83:360-8.

(7.) Suzuki K, Pereira JA, Frias LA, Lopez R, Mutinelli LE, Pons ER. Rabies-vaccination coverage and profiles of the owned-dog population in Santa Cruz de la Sierra, Bolivia. Zoonoses Public Health. 2008;55:177-83. http://dx.doi.org/ 10.1111/j.1863-2378.2008.01114.x

(8.) Millien MF, Pierre-Louis JB, Wallace R, Caldas E, Rwangabgoba JM, Poncelet JL, et al. Control of dog mediated human rabies in Haiti: no time to spare. PLoS Negl Trop Dis. 2015;9:e0003806. http://dx.doi.org/10.1371/journal.pntd.0003806

(9.) Pan American Health Organization; World Health Organization. Epidemiological alert, rabies. 2015 Jun 12 [cited 2016 Sep 21]. http://www.paho.org/hq/index.php?option=com_ docman&task=doc_view&Itemid=270&gid=30660&lang=en

Address for correspondence: Cuc H. Tran, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop A30, Atlanta, GA 30329-4027, USA; email: ywj0@cdc.gov

Cuc H. Tran, Melissa D. Etheart, Lesly L. Andrecy, Pierre Dilius Augustin, Maxwell Kligerman, Kelly Crowdis, Paul Adrien, Amber Dismer, Jesse D. Blanton, Max Millien, Ryan M. Wallace

Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.H. Tran, M. Kligerman, A. Dismer, J.D. Blanton, R.M. Wallace); US Centers for Disease Control and Prevention, Port au Prince, Haiti (M.D. Etheart); Ministere de la Sante Publique et de la Population, Delmas, Haiti (L.L. Andrecy, P. Adrien); Ministere de l'Agriculture, des Resources Naturelles et du Developpement Rural, Port au Prince (P.D. Augustin, M. Millien); Christian Veterinary Mission, Port au Prince (K. Crowdis)

DOI: https://doi.org/10.3201/eid2401.161555

Caption: Figure. Investigation for probable cases of canine rabies transmission to humans, Haiti, 2015. A) Timeline of investigation and B) outcomes. CDC, Centers for Disease Control and Prevention.
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Article Details
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Title Annotation:RESEARCH LETTERS
Author:Tran, Cuc H.; Etheart, Melissa D.; Andrecy, Lesly L.; Augustin, Pierre Dilius; Kligerman, Maxwell; C
Publication:Emerging Infectious Diseases
Article Type:Report
Geographic Code:5HAIT
Date:Jan 1, 2018
Words:1433
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