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Insulin-like growth factor-1 and zinc in children with Beta thalassemia minor/Beta talasemi minorlu cocuklarda insulin benzeri buyume faktoru-1 ve cinko.

To the Editor

The article by Karamifar H. et al published in the recent issue of Turkish Hematology on Insulin-like growth factor-1 in children with P-Thalassemia minor called our attention, because we have also studied growth retardation and ILGF-1 in thalassemia major patients [1]. Our previous studies revealed zinc deficiency in Turkish children with P-Thalassemia major. We have studied zinc levels not only in plasma or serum but also in erythrocytes (RBC), hair and urine of the patients by atomic absorbsiyon spectrophotometer and found chronic Zinc (Zn) deficiency (low blood and hair Zn levels) associated with hyperzincuria and growth retardation [2]. Furthermore, we have demonstrated increased linear growth in Thalassemia-major patients when they were supplemented with daily Zn sulphate, in a controlled manner, indicating the fact that Zn was responsible from short stature in these patients [3] ILGF-1 (initially named as somatomedin-C) levels were also measured in some of the thalassemia major patients and found to be low (4) It was an established fact that zinc plays an important role in the synthesis of ILGF-1 in liver [4,5].

It is well documented that normal growth and development in human subjects is not only hormone dependant but is also greatly influenced by nutritional status. Nutritional zinc deficiency occurring in children and infants has been recognized in different parts of the world including the USA [6,7]. It has been shown that trace element Zn affects growth and development in children when it is deficient [6-8].

Therefore, we strongly suggest the authors that they further study zinc status in their thalassemia-minor patients.

Received: December 15, 2009


[1.] Karamifar H. Karimi, Sobhani N. Insulin-like growth factor-1-levels in children with, Beta-thalassemia minor. Turkish J. Hematology. 2008; 25:136-139.

[2.] Dogru, U, Arcasoy A, Cavdar AO. Zinc levels of plasma, erythrocyte, hair and urine in homozygous beta-thalassemia. Acta Haematol. 1979; 62:41-44.

[3.] Arcasoy A, Cavdar AO, Cin S, Erten J, Babacan E, Gozdasoglu S, Akar N. Effects of zinc Supplementation on linear growth in betathalassemia (A new approach) Am. J. Hematol. 1987;24:127-136

[4.] Cavdar AO, Unal E, Cin S, Kologlu B. Somatomedin C and Zinc Status in [beta]-Thalassemia Major. Annales New York Academy of Sciences. 1990; 612:540-41.

[5.] Cossack ZT Somatomedin-C in zinc deficiency. Experientia. 1984; 40:498.

[6.] Prasad AS. Zinc deficiency in humans in "Zinc Deficiency in Human Subjects" Eds: Prasad AS, Cavdar AO, Brewer GJ, Aggett J, Brewer G. 1983;1-33.

[7.] Prasad AS. Metabolism of Zinc and its deficiency in Human Subjects in "Zinc Metabolism" Ed. Prasad AS, Charles C Thoman. 1966;250.

[8.] Cavdar AO, Arcasoy A, Cin S, Erten J, Babacan E, Gozdasoglu S. Geophagia in Turkey: Iron and zinc absorption studies and response to treatment with zinc in geophagia cases. In Zinc Deficiency In Human Subjects. Eds: Prasad AS, Cavdar AO, Brewer GJ&Agget RJ. 1983;107-116.

Ayhan O. Cavdar (1), Sevgi Gozdasoglu (2)

(1) Turkish Academy of Sciences

(2) Pediatric Hematology Department of Ankara University

Received: February 22, 2009

Author Reply

All the cases has already been on zinc supplement because zinc deficency is common in Iran. We mentioned the first report of zinc deficency in Iran in Turkish Journal of Hematology 2008; 25: 211.

(1) H. Karamifar and (2) M. Karimi

(1) Division of Pediatric Endocrinology, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

(2) Hematology Research Center, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
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Article Details
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Title Annotation:Letter to the editor
Author:Cavdar, Ayhan O.; Gozdasoglu, Sevgi
Publication:Turkish Journal of Hematology
Article Type:Report
Geographic Code:7TURK
Date:Mar 1, 2009
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