Innate Immunity and Inflammation.
Innate Immunity And Inflammation
Ruslan Medzhitov, editor
Cold Spring Harbor Laboratory Press
500 Sunnyside Boulevard, Woodbury NY 11797-2924
9781621820291, $135.00, www.amazon.com
The innate immune system, also known as the nonspecific immune system and the first line of defense, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components. Compiled and edited by Ruslan Medzhitov, "Innate Immunity and Inflammation" is a 240 page compendium comprised of fourteen seminal contributions by experts in the field of immune system studies. The papers range from 'Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors; to The Chemokine System in Innate Immunity; to Inflammation and the Blood Microvascular System; to Approaching the Next Revolution? Evolutionary integration of Neutral and Immune Pathogen Sensing and Response. Enhanced with the inclusion of a five page Index, "Innate Immunity and Inflammation" is a critically important addition to academic library Medical Science reference collections and Immune System Studies supplemental studies reading lists.