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Infraorbital Foramen and Pterygopalatine Fossa Location in Dry Skulls: Anatomical Guidelines for Local Anesthesia.

1. Introduction

Nerve blocks, used to anesthetize the maxillary incisors, canine, and premolars, target the infraorbital nerve (ION) [1], a branch of the maxillary division (V2) of the trigeminal nerve. The ION enters the orbit through the inferior orbital fissure and then transverses the infraorbital canal located under the floor of the orbit [2]. While the ION is in the canal, it provides sensory innervations to the maxillary anterior teeth (anterior superior alveolar nerve), premolars (middle superior alveolar nerve), and associated gingiva. The ION exits the orbit through the infraorbital foramen (IOF) where it becomes a terminal branch, dividing into three branches that provide sensory innervations to the upper lip (superior labial nerve), lateral side of the nose (lateral nasal nerve), and lower eyelid (inferior palpebral nerve).

The greater palatine nerve (GPN) is a branch of the pterygopalatine ganglion that descends downward into greater palatine canal (GPC) and emerges into the oral cavity at the level hard palate through the greater palatine foramen.

The IOF is located in close proximity to vital anatomical structures; therefore proper identification of its location during regional block anesthesia is highly recommended [3, 4]. However, this can be challenging due to its anatomical variation. Several previous studies attempted to determine the location of the IOF by the use of different reference points during ION block anesthesia. One of the constant reference points used is the maxillary second premolar [2, 5-8], as it lies in the same sagittal plane as the IOF.

A previous research paper used GPC to give a maxillary nerve blockin the superior aspect of the pterygopalatine fossa [2], while another research study inserted the needle at a lower level inside pterygopalatine fossa [9].

The aim of this study was to locate the IOF in relation to the infraorbital margin (IOM) and the alveolar bone process of the maxilla at the second premolar for proper injections of local anesthetics, as well as to determine the depth of needle penetration into the pterygopalatine fossa through GPC to avoid serious complications following nerve block anesthesia.

2. Materials and Methods

The materials used in this study consisted of 102 halves of 51 dry intact adult skulls that were examined in the Gross Anatomy Laboratory at the University of Detroit Mercy School of Dentistry. The age and gender of the skulls were not available.

2.1. Measurement of IOF in relation to IOM and Maxillary Alveolar Ridge at the Second Premolar. Superior border of IOF directly overlying the IOF was the main reference point from which vertical measurements to IOM and maxillary alveolar ridge at the second premolar were recorded. Therefore skulls that had fractures in the IOF, IOM, and GPC were excluded. The vertical distance was measured from the highest point of the IOF to the IOM, parallel to sagittal plane and perpendicular to Frankfurt plane. Another vertical distance measured was the distance from the most superior border of IOF to the maxillary alveolar ridge at the second premolar, parallel to sagittal plane and perpendicular to Frankfurt plane (Figure 1). The vertical distances were measured using a digital caliper (Mitutoyo 500-196-30 0-6") of 0.01 mm precision.

2.2. Measurement of Needle Penetration Depth into the Pterygopalatine Fossa. A 25-gauge, 32 mm needle was bent at 45[degrees] angle immediately after the hub, at the beginning of the shaft, and a rubber stopper was introduced into the needle. Then, the needle was inserted through the GPF and once the needle tip approached the pterygopalatine fossa and became visible, the rubber stopper was adjusted at the level of the hard palate and the depth of needle penetration was measured (Figure 2).

3. Results

There were no statistically significant differences between right and left sides of the skull for IOF-IOM, IOF-Maxillary alveolar process at the second premolar and GPC measurements (Table 1). The median, mode, and range were comparable for each set of measurements in both halves. The distance between the IOF and maxilla was more than 4 times greater than the distance between the IOF and IOM. The depth of GPC was significantly smaller than the distance between the IOF and the maxilla. Demographic information, such as age and gender, of the skull was not available; thus, comparing our results based on this data was not performed.

4. Discussion

In this study, we determined the location of the IOF and its distance from two important anatomical structures, the IOM and the alveolar process of the maxilla in 51 human skulls from a gross anatomy laboratory. Superior border of IOF was our main reference point as it is prominent and locating this anatomic landmark is easily identified on patients by dentists. Therefore, the results in our study are clinically applicable and dentists can use these references as an approximation during nerve block anesthesia.

Previous studies used the piriform aperture as a reference to locate the IOF, which dentists cannot palpate clinically on patients, thus making it an unreliable measure to approximate the IOF location [14, 15]. Therefore, we used the superior border of IOF as our main reference point for identifying the location of the IOF, as this is a prominent feature that can be easily distinguished on patients during dental procedures. We found that the distance from IOM to either structure was not significantly different between the different hemispheres of the skull. Furthermore, there was little variation among the samples tested: 6.6 [+ or -] 1.65 mm from the IOF to IOM and 29.23 [+ or -] 1.65 mm from IOF to alveolar process of the maxilla at the second premolar.

Previously published literature examining the distance between IOF and IOM showed results comparable to our study (Table 2). However, slight discrepancies in the results of these studies might be attributed to the population studied, type of specimens (dry skulls or images), and the method of measurement used to acquire the data.

Using the IOF as a reference due to its ease of identification by the practitioner, as well the distances measured in this study as a general guide are clinically applicable for use as an approximation for ION block anesthesia.

An additional aim was to determine the depth of needle penetration into pterygopalatine fossa through GPC to help dentists avoid serious complications following regional block anesthesia. The hard palate approximately forms a 60[degrees] angle with GPC [16] and the patient is usually seated in a semi-reclined position with the mouth opened and head tilted back. Therefore, to prevent further penetration of the needle deep into the pterygopalatine fossa, we suggested bending the needle at 45[degrees] angle. Once the tip of the needle approached the pterygopalatine fossa and became visible, the rubber stopper was adjusted at the level of hard palate and the depth of needle penetration was measured. The clinical significance of this technique is to avoid injury to nearby nerves and blood vessels during injections of local anesthetic solution. In a previous study conducted by Mercuri [2] the author suggested bending the needle at a 30[degrees] angle before inserting it into the most superior border of the pterygopalatine fossa. However, with this technique, the tip of the needle was in close proximity to the main trunk of maxillary artery and pterygopalatine ganglion. Branches from the pterygopalatine ganglion supply the nasal cavity and roof of the oral cavity and spread to the ocular regions [1] which might increase the risk of anesthetizing the ocular nerves. The technique followed in this paper is more favorable than Mercuri's [2] technique, as it prevents further progression of the needle beyond the bend which in return will avoid the incidence of injury and simultaneously ensures that profound anesthesia is obtained in that area with least postoperative complications.

In this study, the age of the skulls and their gender were not available; thus the effect of gender on the location of IOF could not be evaluated. Another limitation is that the maxillary alveolar process may resorb as a result of aging, following tooth extraction or due to periodontal disease.

5. Conclusion

The average distance between the IOF and IOM in dry intact human skulls was 6.6 [+ or -] 1.65 mm and the average distance between IOF and alveolar bone process of the maxilla at second premolar was 29.23 [+ or -] 1.65 mm. The average depth of penetration of needle into GPC was 17.41 [+ or -] 2.69 mm. We recommend bending the needles at a 45[degrees] angle to facilitate entry into GPC. Without this bend, further penetration of the needle might lead to serious complications following local anesthesia injections. Therefore, proper identification of the location of IOF and pterygopalatine fossa is highly recommended during regional block anesthesia and surgical procedures, due to the close proximity to vital anatomic structures.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Please Note: Illustration(s) are not available due to copyright restrictions.

https://doi.org/10.1155/2017/1403120

References

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[2] L. G. Mercuri, "Intraoral second division nerve block," Oral Surgery, Oral Medicine, Oral Pathology, vol. 47, no. 2, pp. 109-113, 1979.

[3] A. Aggarwal, H. Kaur, T. Gupta et al., "Anatomical study of the infraorbital foramen: a Basis for Successful Infraorbital Nerve Block," Clinical Anatomy, vol. 28, no. 6, pp. 753-760, 2015.

[4] I. A. M. Radwan, S. Saito, and F. Goto, "High-concentration tetracaine for the management of trigeminal neuralgia: quantitative assessment of sensory function after peripheral nerve block," The Clinical Journal of Pain, vol. 17, no. 4, pp. 323-326, 2001.

[5] M. S. Chung, H. J. Kim, H. S. Kang, and I. H. Chung, "Locational relationship of the supraorbital notch or foramen and infraorbital and mental foramina in Koreans," Acta Anatomica, vol. 154, no. 2, pp. 162-166, 1995.

[6] S. R. Aziz, J. M. Marchena, and A. Puran, "Anatomic characteristics of the infraorbital foramen: a cadaver study," Journal of Oral and Maxillofacial Surgery, vol. 58, no. 9, pp. 992-996, 2000.

[7] W. Apinhasmit, S. Chompoopong, D. Methathrathip, R. Sansuk, and W. Phetphunphiphat, "Supraorbital Notch/Foramen, infraorbital foramen and mental foramen in Thais: anthropometric measurements and surgical relevance," Journal of the Medical Association of Thailand, vol. 89, no. 5, pp. 675-682, 2006.

[8] M. Kazkayasi, A. Ergin, M. Ersoy, O. Bengi, I. Tekdemir, and A. Elhan, "Certain anatomical relations and the precise morphometry of the infraorbital foramen-canal and groove: an anatomical and cephalometric study," The Laryngoscope, vol. 111, no. 4 I, pp. 609-614, 2001.

[9] R. Douglas and P.-J. Wormald, "Pterygopalatine fossa infiltration through the greater palatine foramen: where to bend the needle," The Laryngoscope, vol. 116, no. 7, pp. 1255-1257, 2006.

[10] A. M. Hindy and F. Abdel-Raouf, "A study of infraorbital foramen, canal and nerve in adult Egyptians," Egyptian Dental Journal, vol. 39, no. 4, pp. 573-580,1993.

[11] R. S. Esper, J. Yara, Y. Yamamura, and S. V Cricenti, "Relacoes anatomicas do ponto de acupuntura E-2 (Sibai) localizado no forame infra-orbital," Revista Paulista de Acupuntura, vol. 4, no. 1, pp. 19-22, 1998.

[12] S. Canan, O. M. Asim, B. Okan, C. Ozek, and M. Alper, "Anatomic variations of the infraorbital foramen," Annals of Plastic Surgery, vol. 43, no. 6, pp. 613-617, 1999.

[13] P. Karakas, M. G. Bozkir, and O. Oguz, "Morphometric measurements from various reference points in the orbit of male Caucasians," Surgical and Radiologic Anatomy, vol. 24, no. 6, pp. 358-362, 2003.

[14] V. C. Macedo, R. R. Cabrini, and H. Faig-Leite, "Infraorbital foramen location in dry human skulls," Brazilian Journal of Morphological Sciences, vol. 26, no. 1, pp. 35-38, 2009.

[15] R. Singh, "Morphometric analysis of infraorbital foramen in Indian dry skulls," Anatomy and Cell Biology, vol. 44, no. 1, pp. 79-83, 2011.

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Omar Masabni (1) and Maha Ahmad (2)

(1) Department of Periodontology and Dental Hygiene, University of Detroit Mercy School of Dentistry, Detroit, MI, USA

(2) Department of Biomedical and Diagnostic Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI, USA

Correspondence should be addressed to Maha Ahmad; ahmadmk1@udmercy.edu

Received 25 August 2017; Accepted 3 December 2017; Published 19 December 2017

Academic Editor: Ruijin Huang

Caption: Figure 1: It shows the frontal view of a human skull. Distances were calculated as shown in the figure. A parallel longitudinal line to the midsagittal plane from (A) the superior border of infraorbital foramen (IOF) to the maxillary alveolar ridge and (B) from the superior border of the IOF to the infraorbital margin (IOM).

Caption: Figure 2: (a) shows insertion of needle bent at a 45[degrees] angle through greater palatine foramen into greater palatine canal. (b) shows the needle tip (circle) as it projects out of the greater palatine canal into pterygopalatine fossa.
Table 1: Anatomical measurements taken by a digital caliper in mm.
* SD: standard deviation.

                                           Right

Measurements   Mean [+ or -] SD *    Median   Mode     Range

IOF-IOM        6.46 [+ or -] 1.57      6       6       4-11
IOF-Max        29.07 [+ or -] 3.58    28.5    30.5   20.5-36.5
GPC            17.56 [+ or -] 2.88     17     18.5   11.5-25.5

                                           Left

Measurements   Mean [+ or -] SD *    Median   Mode     Range

IOF-IOM        6.74 [+ or -] 1.72      6       6       3-12
IOF-Max        29.39 [+ or -] 3.78     29      31      21-36
GPC            17.25 [+ or -] 2.51     17     16.5   11.5-23.5

Measurements       Mean Total

IOF-IOM         6.6 [+ or -] 1.65
IOF-Max        29.23 [+ or -] 1.65
GPC            17.41 [+ or -] 2.69

Table 2: Studies comparing locations of IOF to IOM sorted by date.

Studies            Measurements (mm)

1993, Hindy and          6.10
Abdel-Raouf [10]

1995, Chung              8.60
et al. [5]

1998, Silva [11]         6.80

1999, Canan [12]     Females: 8.30
                     Males: 10.90

2000, Aziz           Females: 7.80
et al. [6]            Males: 8.50

2001, Kazkayasi          7.19
et al. [8]

2002, Karakas            6.70
et al. [13]

2009, Macedo             6.37
et al. [14]

2011, Singh [15]         6.16

2015, Aggarwal           6.32
et al. [3]

2017, this study         6.60

Studies            Number of skulls, ethnic background

1993, Hindy and            (i) 30 adult skulls
Abdel-Raouf [10]   (ii) 15 adult human cadavers, Egypt

1995, Chung                 124 skulls, Korea
et al. [5]

1998, Silva [11]             100 human skulls

1999, Canan [12]               45 cadavers

2000, Aziz                     47 cadavers
et al. [6]

2001, Kazkayasi                  Cadavers
et al. [8]

2002, Karakas                 31 Caucasians
et al. [13]

2009, Macedo                 295 human skulls
et al. [14]

2011, Singh [15]             55 Indian skulls

2015, Aggarwal             67 dry adult skulls
et al. [3]

2017, this study             51 human skulls

Studies               Measurements done

1993, Hindy and        (i) Dry skulls
Abdel-Raouf [10]   (ii) Radiographs (panor

1995, Chung              Photographs
et al. [5]

1998, Silva [11]           Skulls

1999, Canan [12]           Skulls

2000, Aziz                 Skulls
et al. [6]

2001, Kazkayasi        Microscopically
et al. [8]

2002, Karakas              Skulls
et al. [13]

2009, Macedo               Skulls
et al. [14]

2011, Singh [15]           Skulls

2015, Aggarwal             Skulls
et al. [3]

2017, this study           Skulls
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Title Annotation:Research Article
Author:Masabni, Omar; Ahmad, Maha
Publication:Anatomy Research International
Article Type:Report
Geographic Code:1USA
Date:Jan 1, 2018
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