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Inflammatory Support products innovative insights.

It is a fact that the majority of degenerative diseases are driven by chronic subclinical inflammation. Traditionally, this inflammation is viewed as part of the healing process but, although this is true to a certain extent, when inflammation becomes chronic, it becomes a disease. The study of inflammation has now extended beyond tissue level to encompass the nuclear. Nuclear Factor-Kappa B (NF-kB) is a cell signalling molecule for inflammation and its activation induces the expression of cyclooxygenase-2 (COX-2), an enzyme that triggers tissue inflammation. NF-kB activation is a major mediator of inflammation in most diseases and its inhibition can help to prevent or delay the onset of the condition.

Formulations for Anti-Inflammatory Support

NiLitis SR is a sustained release bilayered tablet and a proprietary composition comprising Curcumin [C.sup.3] Complex, boswellin and ginger extract to naturally support the management of pain and discomfort without undesirable side-effects. The sustained release ensures that the nutrients are released and absorbed in efficacious amounts during a period of 8 hours, supporting the management of inflammation and pain throughout the day.

Ingredients

Curcumin [C.sup.3] Complex is obtained from the dried roots and rhizomes of Curcuma longa and standardized for a minimum of 95% curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin). In the Indian system of Ayurvedic medicine, turmeric has a long history of use in the treatment of painful conditions, ranging from sore throats to arthritis. It is a patented and clinically evaluated 'bioprotectant' and has been recognized for its antioxidant benefits. Curcumin helps to suppress NFkB activation and, as a result, inflammation and a host of its manifestations. In a series of experiments, rats were treated with different preparations and dosages of turmeric extracts. The results--mainly measured in terms of joint swelling--suggested that a turmeric extract containing more than 94% of the three major curcuminoids was more potent in preventing arthritis than crude turmeric extracts. Only curcuminoid-containing formulae appeared as safer and more effective at lower doses. Curcuminoids also prevented bone loss in addition to joint inflammation.

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Boswellin--obtained from the gum resin of Boswellia serrata and standardized for 40% acetyl 11-keto beta boswellic acid (AKBBA)--is used in Ayurvedic medicine in the management of inflammatory disorders. Boswellic acids--with AKBBA being the most potent--are reported to be non-competitive

inhibitors of 5-lipoxygenase enzyme and block Human Leukocyte Elastase (HLE) activity; a unique dual inhibition. The antiarthritic potential of B. serrata extracts is also a result of its ability to reduce various inflammatory markers, such as TNF- [alpha], IL1- [beta] and nitric oxide. It can be recommended in patients suffering from osteoarthritic knees and may also possess therapeutic utility in the management of other forms of arthritis, such as joint, rheumatoid and spondylosis.

Ginger extract is derived from the dried rhizomes of Zingiber officinale, standardized for 35% gingerols and is well documented in Ayurvedic medicine for its anti-inflammatory properties. Ginger helps to reduce inflammation by inhibiting prostaglandin biosynthesis, specifically COX-1 and COX-2. These effects make ginger comparable with non-steroidal, anti-inflammatory medications, although it does not cause their typical side-effects. Ginger also suppresses the immune system's production of proinflammatory cytokines and chemokines, reducing disease severity in patients with rheumatoid arthritis. A single centred, open-labelled study was conducted in 30 osteoarthritic subjects between the ages of 40 and 65, during a 56 day period. Subjects were given two tablets of NiLitis SR orally twice a day. Parameters assessed--including WOMAC scores, VAS pain scale and distance covered in 6 minutes--displayed significant improvement and no adverse effects were noted.

ArthriBlend-SR is a sustained release composition containing glucosamine sulphate, boswellin and Curcumin C3 Complex--ingredients that work synergistically to support the management of inflammatory conditions such as arthritis. In addition, it contains BioPerine (Piper nigrum), a patented bioavailability enhancer. ArthriBlend-SR has also undergone clinical evaluation. A double blind, randomized study was designed to evaluate its efficacy and the results suggest that, compared with glucosamine sulphate alone, a combination of glucosamine sulphate, Boswellia serrata and curcuminoids is more effective in relieving pain and stiffness in patients with osteoarthritis of the knee.

The results--mainly measured in terms of joint swelling--suggested that a turmeric extract containing more than 94% of the three major curcuminoids was more potent in preventing arthritis than crude turmeric extracts.

For more information

Ajax K. Mohamed Vice President, Sales Sabinsa Europe GmbH

Tel. +49 6103 2701 117

ajax.mohamed@sabinsa.com

www.sabinsa.com
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Title Annotation:herbals and botanicals
Publication:Nutraceutical Business & Technology
Geographic Code:1USA
Date:Sep 1, 2011
Words:734
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