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Indigo Biosciences unveils human estrogen-related orphan receptor gamma assay system.

M2 PHARMA-September 18, 2014-Indigo Biosciences unveils human estrogen-related orphan receptor gamma assay system


18 September 2014 - US nuclear receptor screening specialist Indigo Biosciences said Thursday it had launched a human estrogen-related orphan receptor gamma (NR3B3; ERR?) assay system, including three different assay kits.

ERR? is naturally expressed in the central nervous system and at lower relative levels in multiple other tissue types, such as kidney, pancreas, skeletal muscle, heart and prostate. There has also been demonstrated cross-talk between ERR? and the estrogen receptor alpha. Moreover, functional interactions between these two nuclear receptors may influence endocrine signaling participating in the progression of breast and prostate cancers. ERR? is a potential therapeutic target for these diseases, as well as a target for anti-obesity drugs.

The nuclear receptor assay system uses proprietary mammalian reporter cells to provide high-level expression of a hybrid form of the human estrogen-related receptor gamma. In addition, the cells utilise the luciferase reporter gene, which provides a highly sensitive measure of changes in ERR? activity as a result of exposure to the user's test compounds, Indigo chief scientific officer, Dr. Jack Vanden Heuvel, noted.

The company's human ERR? assay kits are an all-inclusive, single use assay system. Besides ERR? reporter cells, the kits incorporate optimised media for use during cell culture and in diluting user test samples, a reference inverse-agonist, Luciferase Detection Reagent and a cell culture-ready assay plate. The kits are offered in 96-well, 3x32-well and 384-well assay formats.

Indigo Biosciences has a portfolio of nuclear receptor screening products and services, in addition to non-human nuclear receptor assays, functional assays and custom assay development. Its reporter cells are prepared using the firm's CryoMite process, which ensures long-term cryo-preservation of cells for shipment and storage, enabling on-demand use of the products in customers' labs.

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Publication:M2 Pharma
Date:Sep 18, 2014
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