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Inauguration of the Centro 3R for the Promotion of 3Rs Principles in Teaching and Research.

The first European interuniversity center dedicated to promoting 3Rs principles in teaching and research was inaugurated in Pisa, Italy on March 14, 2018. The Centro 3R (1) was spearheaded by the Universities of Pisa and Genoa. Membership is open to all Italian universities and agreements for twinning across Europe and other countries are being pursued.

The event was attended by around 90 participants including the press, members of animal welfare associations, pro-life associations, industry, technology hubs, scientists and students. It was officially opened by the Vice Rector of the University of Pisa, Professor Nicoletta De Francesco and the Rector of the University of Genoa, Professor Paolo Comanducci. They both remarked on the timeliness of the initiative and the relevance of teaching and learning in the context of the 3Rs as well as the role of universities in free learning and research. Nicoletta De Francesco highlighted the University of Pisa's commitment to animal welfare and new technology and invited other universities to join the initiative. Their opening speeches were followed by a brief outline of the Centro 3R's objectives by Arti Ahluwalia, the current director. She described the Centro's mission to promote rational and scientific thinking in experimental science through a multidisciplinary teaching and research approach inclusive of all 3Rs as a means to accelerate the R of replacement. The projects to develop an open resource-sharing web platform and interdisciplinary elective courses were also mentioned.

Following the introductory speeches, Francesca Pistollato expressed EURL ECVAM's endorsement and support for the Centro 3R. She gave an overview of the resources available through the EU and JRC and discussed the importance of multidisciplinarity for pushing forward non-animal technology. Costanza Rovida from CAAT-Europe also congratulated the new Centro 3R and showed some examples of how associations and research groups come together to generate excellence. She underlined that the use of new technology including fluidics, adverse outcome pathway identification, bioinformatics and stem cells requires a multidisciplinary approach, which is fostered by knowledge sharing. The Centro 3R is a pioneering example. The director general of animal welfare at the Italian Ministry for Health, Dr Silvio Borrello, offered congratulatory messages to the Centro 3R and remarked on the importance of the initiative, as did Isabella De Angelis and Emanuela Testai from the Italian Institute of Health (ISS) and the Italian Platform for Alternative Methods (IPAM) by means of a brief but inspiring letter that was read out.

Massimo Riccaboni, professor of economics at IMT School for Advanced Studies in Lucca, Italy gave a lecture on "Pharmacoeconomics, transparency and public opinion", illustrating, with concrete examples how the (high) price of drugs is determined by clinical trial failures and how this could be mitigated by sharing both negative and positive data. He stated that this also applies to research in general, i.e., the high price of scientific research, including the use of animals, could be reduced by sharing data on failed experiments. "Contribution of education and training to Culture of Care" by Jan van der Valk from the 3R Center at the University of Utrecht, the Netherlands pointed out that ensuring an appropriate culture of care will promote improved animal welfare and therefore enhanced scientific outcomes. A thoughtful discourse on the ethics of care was given by the well-known bioethicist Luisella Battaglia, who addressed the role of humans in making decisions about animal welfare and as curators of the planet.

A delicious vegetarian lunch, kindly sponsored by a local caterer, was followed by two excellent lectures on the 3Rs from two different scientific angles. The first, entitled "Pharmacological Research and the 3R principles" from Giambattista Bonnano, University of Genoa, Italy gave evidence on how both industrial and academic pharmacological research, which positively impact our quality of life, still need to rely on animal experiments. According to Bonnano, since Replacement seems to be far from a concrete option at present, Reducing and Refining are the two major challenges to be undertaken for the continuous improvement of animal welfare. The second, "Computational Systems Biology propels the 3Rs", by Corrado Priami, University of Pisa, Italy outlined in a simple but compelling way how computational biology approaches implemented before starting an experiment can lead to an enormous saving in time, money and animals. Rounding off the lectures, Helena Kandarova, MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia presented an informative lecture on "Efforts of international business in 3Rs" and explained how MatTek supports researchers across the globe.

The final item on the program was a round table discussion on the potential of the Centro 3R in science, economics and society chaired by the journalist Marco Colombini. Panelists were Michela Kuan, Italian anti-vivisection league (LAV), Giuliano Grignaschi, Research4Life, Bruna AnnaMaria Monami, LEAL (Anti-Vivisectional League) and Stefano Prete, Toscana Life Sciences. The animated discussion revolved around the impact of eduction, the role of the Centro 3R, and research funding. Mr Colombini summarized the main points of the meeting, stressing the efforts of the Centro3R in promoting the training of young researchers to improve in vivo, in silico and in vitro models and technologies for accelerating the validation and acceptance of alternative methods.

Overall this was an excellent opening for the Centro 3R, with a buzz of new ideas and aspirations to help the advancement of non-animal methods in basic and applied bioscience, spanning from medicine, pharmacology and toxicology to the evaluation of health and environmental risk assessment.

Arti Ahluwalia [1-2], Anna Maria Bassi [1-3] and Paolo Milazzo [1-4]

[1] Centro 3R (Interuniversity Center for the Promotion of 3Rs Principles in Teaching and Research), Italy; [2] Research Center E. Piaggio and Department of Information Engineering, University of Pisa, Pisa, Italy; [3] Department of Experimental Medicine, University of Genoa, Genoa, Italy; [4] Department of Computer Science, University of Pisa, Pisa, Italy

doi: 10.14573/altex.1803201

(1) http://www.centro3r.it
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Article Details
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Title Annotation:Meeting Report
Author:Ahluwalia, Arti; Bassi, Anna Maria; Milazzo, Paolo
Publication:ALTEX: Alternatives to Animal Experimentation
Article Type:Conference news
Geographic Code:4EUIT
Date:Mar 22, 2018
Words:964
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