In men with surgically resected stage I seminoma, a single dose of carboplatin chemotherapy is as effective as 2 to 3 weeks of radiation therapy in preventing recurrence and is much less toxic, according to study findings presented at the American Society of Clinical Oncology annual meeting in Chicago.
Fifteen patients in the radiation arm developed contralateral testicular germ cell cancers versus 2 patients in the carboplatin arm. One patient in the radiation arm died of seminoma versus none in the chemotherapy arm. Adverse effects were low with both treatments, although patients treated with radiation reported higher levels of moderate to severe lethargy (24% vs. 7% for carboplatin) 4 weeks after starting treatment.
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|Title Annotation:||RESEARCH & TECHNOLOGY|
|Article Type:||Brief article|
|Date:||Jun 9, 2008|
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