Idiopathic Orbital Myositis with Pseudosixth Nerve Palsy: The Importance of Neuroimaging/Psodoaltinci Kranyal Sinir Felci ile Gelen Idyopatik Orbital Miyozit Olgusu: Norogoruntulemenin Onemi.
Anahtar Kelimeler: Orbital miyozit, psodotumor orbita, altinci sinir felci, manyetik rezonans goruntuleme
A 48-year-old female was admitted with a right hemicranial, throbbing headache for 10 days that intensified behind the right eye and horizontal diplopia worsening with right gaze. There was no feature in her medical history and resume. Neurological examination revealed inward deviation of her right eye in primary position and 3-mm abduction failure. There was also a mild right sided proptosis. Fundus examination was normal.
Blood biochemistry tests, complete blood count, thyroid function tests and autoantibodies and glycosylated hemoglobin level were normal. Vasculitic markers (ANA, p-ANCA, c-ANCA, anti-ds-DNA, AMA, ASMA, anti-Scl-70, anti-Jo-1, anti-SSA, anti-SSB), anti-acetylcholine receptor antibody and infectious serologic markers (hepatitis B surface antigen, herpes simplex virus type 1 and type 2 IgM anti-HIV, Brucella, Varicella-Zoster virus IgM, anti-HCV, VDRL-RPR) were negative. Cranial computed tomography and contrast-enhanced magnetic resonance imaging (MRI) were normal. Nerve conduction studies, needle electromyography and repetitive nerve stimulation were normal. Cerebrospinal fluid was acellular and biochemistry was normal. IgG index was within normal ranges (0.37).
Right medial rectus muscle was hypertrophic and iso-hyperintense in T2, and contrast-enhanced, fat-suppressed T1-weighted images (Figure 1A, 1B, 1C, 1D). Myotendinous junction was also involved (Figure 1A, 1B).
With specific orbital MRI findings, our patient was diagnosed as having "idiopathic orbital myositis". Methylprednisolone treatment of 80 mg/day p.o was initiated. Signs and symptoms improved in the first week of treatment and the patient fully recovered in the second week. The steroid dose was tapered gradually, until the lowest maintenance dose was sustained.
"Orbital myositis" is an inflammatory disease that primarily effects extraocular muscles (1). Patients are often in their 30s and females are affected twice as frequently as males. Generally, the medial rectus muscle is unilaterally impaired. Acute-onset painful diplopia is the most frequent presenting symptom. Pain may be exacerbated by ocular movements. Limitation of ocular movements, conjunctival edema and proptosis can be detected in neurological examination. Hypertrophy of impaired extraocular muscle(s) shown by neuroimaging is important for diagnosis. Impaired extraocular muscle is seen as thick and hyperintense in T2-weighted imaging (2). Impairment of the myotendinous junction and tendons distinguishes orbital myositis from thyroid ophthalmopathy. Frequently, the etiology of orbital myositis is unknown. Histopathology of orbital myositis, also known as "idiopathic inflammatory orbital syndrome", reveals mixed inflammation consisting of fibrosis in various degrees, plasma cells, lymphocytes, macrophages, and polymorphonuclear leukocytes (3). Other causes leading to ophthalmoparesis, in particular; primary vascular diseases (e.g., ischemia, hemorrhage, aneurysm or carotid-cavernous fistula of the brain stem), diseases with vascular complications such as hypertension and diabetes mellitus, granulomatous or inflammatory disorders of cavernous sinus like thyroid ophthalmopathy and Tolosa-Hunt syndrome, neuromuscular junction disorders such as myasthenia gravis and acute polyneuropathy syndromes like Fisher syndrome should be kept in mind in differential diagnosis (4). Systemic corticosteroids are used in treatment of orbital myositis. Non-steroidal immunosuppressants can also be used as maintenance and/or prophylactic treatment. Infliximab and radiotherapy can be used in unresponsive patients (5). Recurrence is frequent. In summary, the differential diagnosis of a patient presenting with isolated extraocular muscle palsy can be challenging. Steroid-responsive idiopathic orbital myositis should be kept in mind in conditions mimicking sixth nerve palsy.
Informed Consent: Informed consent was obtained from the patient.
Peer-review: Internally peer-reviewed.
Surgical and Medical Practices: Z.E.B., S.A.B., O.O., S.S., C.D., H.H.S., H.D.A., Concept: Z.E.B., S.A.B., Design: Z.E.B., S.A.B., Data Collection or Processing: Z.E.B., S.A.B., O.O., S.S., C.D., H.H.S., H.D.A., Analysis or Interpretation: Z.E.B., S.A.B., O.O., S.S., C.D., H.H.S., H.D.A., Literature Search: Z.E.B., O.O., S.S., H.D.A., Writing: Z.E.B., S.A.B.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study has received no financial support.
(1.) Skorin L Jr, English RF. Orbital myositis. J Am Osteopath Assoc 2014;114:135.
(2.) Pakdaman MN, Sepahdari AR, Elkhamary SM. Orbital inflammatory disease: Pictorial review and differential diagnosis. World J Radiol 2014;6:106-115.
(3.) Albu CV, Catalin B, Zaharia C. A rare case of ocular myositis. Curr Health Sci J 2014;40:71-74.
(4.) Schoser BG. Ocular myositis: diagnostic assessment, differential diagnoses, and therapy of a rare muscle disease - five new cases and review. Clin Ophthalmol 2007;1:37-42.
(5.) Garrity JA, Coleman AW, Matteson EL, Eggenberger ER, Waitzman DM. Treatment of recalcitrant idiopathic orbital inflammation (chronic orbital myositis) with infliximab. Am J Ophthalmol 2004;138:925-930.
Zeynep Ezgi Balcik (1), Sezin Alpaydin Baslo (1), Oya Ozturk (1), Songul Senadim (1), Cengiz Dayan (1), Hatem Hakan Selcuk (2), Hayrunnisa Dilek Atakli (1)
(1) Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey
(2) Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey
Address for Correspondence/Yazisma Adresi: Zeynep Ezgi Balcik MD, Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey
Phone: +90 505 456 29 52 E-mail: email@example.com ORCID ID: orcid.org/0000-0002-2882-7646
Received/Gelis Tarihi: 05.04.2017 Accepted/Kabul Tarihi: 24.07.2017
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|Title Annotation:||Images in Clinical Neurology / Klinik Gorunum|
|Author:||Balcik, Zeynep Ezgi; Baslo, Sezin Alpaydin; Ozturk, Oya; Senadim, Songul; Dayan, Cengiz; Selcuk, Hat|
|Publication:||Turkish Journal of Neurology|
|Article Type:||Letter to the editor|
|Date:||Mar 1, 2018|
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