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Idiopathic Myointimal Hyperplasia of Mesenteric Veins of the Ileum and Colon in a Patient with Crohn's Disease: A Case Report and Brief Review of the Literature.

1. Introduction

Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a poorly understood disease that poses a diagnostic challenge to clinicians and pathologists. Clinically and endoscopically, patients appear to have inflammatory bowel disease (IBD); however, biopsies show ischemic abnormalities without the classic features of IBD. Patients have a relatively protracted clinical course refractory to medical treatment, and it is not until the diseased bowel segment is resected that histology reveals the underlying etiology. IMHMV is characterized by thickened small and medium-sized mesenteric veins with the hallmark feature of intimal smooth muscle proliferation, leading to luminal occlusion and mucosal ischemic changes. Herein, we present a case of IMHMV in a 59-year-old man with a long-standing history of Crohn's disease.

2. Case Presentation

A 59-year-old man with a 30-year history of Crohn's disease was referred to our institution for ongoing symptoms of bloating, abdominal pain, and alternating bouts of constipation and diarrhea with occasional incontinence despite treatment with infliximab and azathioprine. He had three prior small bowel resections at the ileocecal junction for intestinal obstruction with the last surgery performed 15 years ago. The two prior resections, according to pathology reports available for review, demonstrated changes consistent with Crohn's disease, including transmural inflammation and multiple inflammatory pseudopolyps.

His most recent colonoscopy at the outside institution showed patchy mild inflammation from the rectum to descending colon; however, surveillance was limited by adhesions and strictures preventing passage of the colonoscope proximal to 50 cm. Endoscopic biopsies obtained every 10 cm did not reveal any active disease or dysplasia. A CT scan showed diffuse mucosal thickening and edema from the rectum to descending colon with edema of the pericolic fat. MR enterography subsequently performed at our institution revealed minimally active inflammatory disease from the rectosigmoid to descending colon without any evidence of complications or active disease involving the neoterminal ileum.

Due to nonresolution of his symptoms a decision was then made to proceed with an open subtotal abdominal colectomy with end ileostomy and Hartmann's pouch formation. Grossly, the specimen received was composed of a portion of ileum anastomosed to a markedly dilated colon, including the sigmoid colon, and notable for extensive fat wrapping associated with dense, indurated mesenteric adipose tissue, particularly in the mid and distal colon (Figure 1(a)). The wall of the ileum and colon were thickened and edematous but revealed an otherwise unremarkable mucosal surface with no strictures, ulcerations, fissures, fistulas, pseudopolyps, or perforations (Figures 1(b) and 2(a)). Gross examination of the resection specimen was also significant for soft submucosal nodules scattered throughout the colon.

Histologic evaluation revealed myointimal hyperplasia of the mesenteric veins in the peri-ileal (Figure 2) and pericolic (Figure 3) soft tissue as confirmed by elastin stain as well as significant muscularis propria hypertrophy. Absent were the classic findings of chronicity (mucosal crypt architectural distortion, left-sided Paneth cell metaplasia, transmural chronic inflammation, fistulas, and fissures), and acuity (cryptitis, crypt abscesses, and ulcerations) associated with Crohn's disease and mucosal ischemic changes typically seen with IMHMV. Additionally, there was no evidence of small or large vessel vasculitis. The scattered submucosal nodules were revealed to be lipomas.

Postoperatively, the patient made a gradual recovery and was discharged 13 days after surgery. No additional medical management was needed.

3. Discussion

Mesenteric ischemia is most commonly caused by arterial thromboembolic disease and much less commonly by venous occlusion, which, when present, is usually due to venous thrombosis [1]. Idiopathic myointimal hyperplasia of the mesenteric veins is a rare, poorly understood nonthrombotic and noninflammatory vascular disease that mimics IBD. First described in 1991 by Genta and Haggitt, over 22 cases of IMHMV have been reported since that time (Table 1) [2]. This number likely underestimates the true incidence of IMHMV given that biopsies often show nonspecific findings and the condition is routinely diagnosed after histologic review of the resected specimen (only one case to date in the literature was diagnosed preoperatively) [3]. Hence, milder cases that do not require surgical resection may be misdiagnosed.

Classically, IMHMV was thought to be a disease of the rectosigmoid colon affecting young healthy males [4]. Review of the current literature, however, shows the median age at time of diagnosis to be 59 years. Men are more likely to be affected than women by 2.7: 1 with six of the reported cases involving women [3, 5-9]. Additionally, although the majority of cases involve the rectosigmoid colon, numerous cases now have noted extension of the disease proximally along the descending colon as well as involvement of the jejunum [5], ileum [8-10], and entire colon sparing the rectum [11].

The clinical and endoscopic impression is that of IBD in contrast to mucosal biopsy findings, which are more suggestive of an ischemic etiology [4]. Patients typically present with weight loss, abdominal pain, and bloody diarrhea [12, 13]. Colonoscopy may show a friable mucosa with ulcerations and erythematous and edematous changes [14-16]. Full thickness sections show the pathognomonic histologic feature of arterial-sparing intimal smooth muscle hyperplasia of small- and medium-sized mesenteric veins, which can be confirmed by an SMA stain. Additionally, an elastin stain can be used to highlight the elastic laminae present in arteries and absent in the affected veins, an important diagnostic clue [12]. The degree of luminal occlusion is variable but often results in an ischemic pattern of injury such as ulceration, superficial withering of crypts, edema, congestion, and, later on in the disease process, hyalinization and fibrosis of the lamina propria and/or submucosa [3, 6, 11, 17]. Notably absent on histology are chronic inflammatory changes.

In terms of treatment, patients diagnosed with IMHMV have often endured multiple rounds of failed medical therapy for IBD, leading to surgical resection of the diseased bowel. Segmental resection is curative and follow-up for up to 7 years has been uneventful with no recurrence of disease [12].

The case we report here is unique in several ways. To our knowledge, this is the first case of IMHMV with involvement of the neoterminal ileum to sigmoid colon in a patient with a long-standing clinicopathologic history of Crohn's disease. Unlike other cases where time to surgery has ranged from 1 month to 2 years and clinical impression often is that of IBD or ulcerative colitis, this patient presented to our institution with a 30-year history of pathologically demonstrated Crohn's disease. Interestingly, despite the patient's experience of progressively worsening symptoms and the degree of venous occlusion present in his bowel, the resected specimen revealed a normal-appearing mucosa without any ischemic changes. Additionally absent were the classic findings of chronicity and acuity typically associated with Crohn's disease.

The etiology of IMHMV is unknown and pathophysiology remains speculative. The vessel abnormalities in IMHMV have been reported to resemble histologically failed saphenous vein grafts from patients that have undergone aortocoronary bypass surgery [18] as well as stenotic arteriovenous fistulas in dialysis patients [19], suggesting an "arterialization" of veins due to increased intraluminal pressure. Some have proposed that the mobility of the sigmoid colon renders it susceptible to traumatic injury secondary to torsion, volvulus, or stretch, leading to arteriovenous fistulization and ultimately myointimal hyperplasia of the mesenteric veins [18, 20]. However, this mechanism fails to account for the occurrence of IMHMV in other parts of the bowel that lack such mobility and further investigation into the pathogenesis is needed.

4. Conclusion

IMHMV is a challenging diagnosis to make, given the discordant clinical, endoscopic, and biopsy findings. As more cases are reported, the demographics for this entity are also broadening and it is important to keep this condition in the differential for patients with inconsistencies in their presentation. In cases of biopsies showing ischemic changes and blood vessel abnormalities in an anatomic distribution incongruent with ischemic colitis, negative angiography may help point towards a diagnosis of IMHMV [3]. Increased awareness of this disease among clinicians and pathologists may help with earlier recognition of it and ultimately better management of affected patients.

https://doi.org/10.1155/2017/6793031

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this article.

References

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[2] R. M. Genta and R. C. Haggitt, "Idiopathic myointimal hyperplasia of mesenteric veins," Gastroenterology, vol. 101, no. 2, pp. 533-539, 1991.

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[13] C.-K. Chiang, C.-L. Lee, C.-S. Huang, S.-H. Huang, and C.H. Wu, "A rare cause of ischemic proctosigmoiditis: idiopathic myointimal hyperplasia of mesenteric veins," Endoscopy, vol. 44, Supplement 2, pp. E54-E55, 2012.

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Sharon J. Song and Stuti G. Shroff

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

Correspondence should be addressed to Stuti G. Shroff; stuti.shroff@uphs.upenn.edu

Received 21 May 2017; Accepted 12 July 2017; Published 15 August 2017

Academic Editor: Hiroko Kuwabara

Caption: Figure 1: Gross examination of the ileocolonic surgical resection specimen revealed extensive fat wrapping and induration of the peri-ileal and pericolonic adipose tissue (a). Examination of the mucosal surface was relatively unremarkable without evidence of strictures, fistulae, or mucosal ulcers (b).

Caption: Figure 2: Involvement of the neoterminal ileum by idiopathic myointimal hyperplasia of the mesenteric veins. A representative low-magnification view of the ileum revealed an unremarkable mucosa and ileal wall (a). On high magnification, the peri-ileal veins demonstrated myointimal hyperplasia (b) as evidenced by elastin staining (c).

Caption: Figure 3: Paired H&E (a, b) and elastin (c, d) stained high-magnification images of mesenteric vessels in the pericolonic soft tissue. Elastic laminae, visible in the artery (a, c), are absent from the vein (b, d), which shows myointimal hyperplasia.
Table 1: Reported features of Idiopathic myointimal hyperplasia of
mesenteric veins.

Year        Authors         Age/sex    Affected site

2017      Song et al.        59 M     Sigmoid to ileum
2016    Guadagno et al.      59 F          Ileum
2016       Yun et al.        64 M     Rectum to distal
                                         transverse
2015   Wangensteen et al.    62 F       Rectosigmoid
2015     Sahara et al.       76 M       Rectosigmoid
2015     Abbott et al.       58 M        Rectum to
                                      descending colon
2015       Laskaratos        62 F          Ileum
2014    Korenblit et al.     59 M       Rectosigmoid
2013      Thomas [21]        62 M       Rectosigmoid
2013       Feo et al.        75 F       Rectosigmoid
2012     Chiang et al.       60 M       Rectosigmoid
2012     Lanitis et al.      81 M          Ileum
2012    Korenblit et al.     62 M      Entire colon
                                      (rectal sparing)
2011   Garcia-Castellanos    32 F        Rectum to
             et al.                   splenic flexure
2006     Sherman et al.      38 M       Rectosigmoid
1999   Savoie and Abrams     22 M       Rectosigmoid
1998         Bryant          42 F         Jejunum
1996    Abu-Alfa et al.      58 M         Sigmoid
1991   Genta and Haggitt     30 M         Sigmoid
1991   Genta and Haggitt     38 M       Sigmoid to
                                      descending colon
1991   Genta and Haggitt     25 M       Rectosigmoid
1991   Genta and Haggitt     67 M         Sigmoid

Year      Clinical impression      Time to surgery     Follow-up

2017            Crohn's                 30 yr             NA
2016           IBD, NET                 6 mo             3 yr
2016              UC                    2 yr             6 mo
2015             IMHMV                  2 mo            >1.5 yr
2015         IBD, ischemia              1 yr              NA
2015       Colitis, ischemia             NA               NA
2015   Inflammation, ulceration          NA               NA
2014            Colitis                 1 mo             3 mo
2013            Colitis                 1 mo              NA
2013       Ischemic colitis             >6 mo        No recurrence
2012              UC                    2 mo             4 mo
2012         Not reported               6 mo              NA
2012              UC                    18 mo             4d
2011   Pneumatosis intestinalis,        3 mo             24mo
           colon ulceration
2006              IBD                   5 mo             18 mo
1999              UC                     NA              10 mo
1998            Unknown                  NA               NA
1996     IBD, ischemic colitis          >1yr              NA
1991           Stricture                1 mo             7 yr
1991              UC                    2 mo             1 yr
1991              UC                    >6 mo             4yr
1991            Crohn's                 3 mo             2 yr
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Title Annotation:Case Report
Author:Song, Sharon J.; Shroff, Stuti G.
Publication:Case Reports in Pathology
Article Type:Clinical report
Date:Jan 1, 2017
Words:2508
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