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Identifying medication errors in the neonatal intensive care unit and paediatric wards using a medication error checklist at a tertiary academic hospital in Gauteng, South Africa.

Medication errors in paediatrics are relatively understudied in South Africa (SA). The National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) defines a medication error as 'any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer. Such events may be related to professional practice, healthcare products, procedures, and systems, including prescribing, order communication, product labelling, packaging, and nomenclature, compounding, dispensing, distribution, administration, education, monitoring, and use'. [1]

Most medications used in paediatrics are used off-label and hence adult dosage forms are administered, which may increase opportunities for medication errors with subsequent risks for the patient. [2] The most error-prone step in the medication process is prescribing by the prescriber. [3] Dosing errors are the leading cause of medication errors, especially in the paediatric population and more so in the intensive care unit (ICU). [3] Paediatric patients require individualised prescribing of medication based on their age and body weight, together with the interpretation of the therapy outcome. [4] There are five stages of the medication process where medication errors can occur, called the origin of medication errors, [5,6] i.e.: prescribing of medication by a legitimate prescriber; transcribing of the order documentation by someone other than the prescriber for ordering and processing; dispensing, whereby a pharmacist assesses a medication order and releases the product for use by another healthcare professional; administration, where the medication is administered to the patient, including administration of the correct medication to the correct patient at the prescribed time and labelling the current intravenous medication that the patient is receiving; and monitoring to evaluate the patient's response to medication and record the findings. [5,6]

The following types of medication errors are identified and described by various studies: incorrect medicine, incorrect dose, incorrect preparation, expired product, incorrect time, incorrect route, unauthorised medication, omission, wrong patient, mislabelling, incorrect dispensing, incorrect duration of treatment, extra dose, deteriorated medication and contraindication. [5,7-10]

The classes of drugs mostly involved in paediatric medication errors include anti-infectives, sedatives, analgesics, bronchodilators and cardiovascular drugs. [11-13]

The causes of medication errors in general clinical practice can be divided into human and system errors. Human errors consist of performance deficit, procedure or protocol not followed, miscommunication, inaccurate or omitted transcription, improper documentation, knowledge deficit, miscalculations, missing or misplaced zero and decimal points, use of non-standard abbreviations, lack of patient information and lack of patient understanding of their therapy. [5] Human errors are compounded when wards are overcrowded, leading to an increase in workload, generation of more stress, tiredness and sleep deprivation in the healthcare professional, which facilitates the occurrence of more medication errors. [4,5] Factors that contribute to system errors include medications with similar names, complex or poorly designed electronic patient record technology, access to medication by non-pharmacy personnel, drug distribution system errors, computer entry error, lack of system safeguards, and workplace environmental problems that include the daily occupancy rate and the workload of the healthcare professionals. [5]

The severity of medication errors can be categorised (A-sI) based on the effect they have on the patient, as constructed by the NCC MERP. [1,6,14] Currently, in SA, there is no standardised medication error database for the identification and quantification of medication errors in hospitals. However, ongoing safety and effectiveness of medicines is ensured by voluntary reporting systems that form part of pharmacovigilance programmes. [15] These programmes aim to detect, assess, manage and prevent drug-related problems. [15,16]

The importance of the presence of a clinical pharmacist in a paediatric unit to monitor drug treatment and prevent medication errors is well established in some countries. [7,9,17] Clinical pharmacists monitoring medication orders might prevent more than half (58%) of all errors, including 72% of potentially harmful errors. Furthermore, they may improve doctor-pharmacist communication, preventing 47% of all errors. [17] The clinical pharmacist should be involved in double-checking all drug administrations to reduce medication errors. For preventive measures to be successful against medication errors there needs to be collaboration between all healthcare professionals. [13]

This study emphasises that it is the responsibility of the healthcare provider to ensure that patient safety incidents are instantly identified and managed to minimise patient harm and suffering, that errors are routinely investigated and managed to prevent repetition and to learn from errors. [18] To this end the purpose of the study was to determine the incidence of medication errors in neonatal and paediatric inpatients, to investigate the origin of medication errors, and to describe and categorise the types of medication errors made in the neonatal intensive care unit (NICU) and paediatric wards in a tertiary academic hospital.


Study design, study site and population

This study followed an observational, quantitative, descriptive design that was done prospectively. It was conducted in four paediatric wards over a 16-week period at a tertiary academic hospital, which has 28 clinical departments, and is one of four academic institutions in Gauteng Province. It provides a service to the surrounding populations of ~1 700 000 people. The hospital also receives referrals from Limpopo, North West and Mpumalanga provinces. In addition, this facility receives referrals from Southern African Development Community (SADC) countries, other tertiary academic hospitals, local specialists and general practitioners. The hospital has 1 650 active beds, 22 approved ICU beds, 60 high-care beds and 17 theatres. The four paediatric wards under study consisted of a 40-bed orthopaedics ward, a 40-bed surgical ward, a 20-bed oncology ward and a 55-bed NICU.

Data collection and data collection instruments

Neonatal and paediatric inpatient medical files for background of the patient's disease and current condition and the patients' medication charts were reviewed to evaluate what was prescribed by the physicians and documented as administered by the nurses. The method of how and when nurses prepared (reconstituted) and administered medication to the patients was directly observed by the researcher. The dispensing process was evaluated for the correct drug, dosage form and on-time dispensing when a prescription was sent to the pharmacy. Direct observation occurred 5-7 hours per day, 5 days a week, for the 16-week study period.

A medication error checklist was designed according to recommendations from several studies. [5-10,14] The definitions of the various types of errors were adopted from previous studies and are defined in Table 1. [5,8,11,13,14]

The medication error checklist was validated in a pilot study of 10 patients and minor amendments were made. The checklist was subsequently used to capture the following information, as outlined by the objectives: the origin of medication errors (e.g. prescription or administration), the type of medication errors that occurred e.g. incorrect dose or inadequate preparation) and the cause of the medication errors (e.g. miscalculation or inexperienced staff), after which it was categorised (Table 2) according to the NCC MERP for data analyses. [1]

Data analysis

The data from the medication error checklists were imported into Statistical Analysis System (SAS) release 9.3 (USA) for statistical analysis. Descriptive statistics were used to analyse and summarise data to obtain the frequency of occurrence of medication errors. Incidence of medication errors was calculated as a percentage with 95% confidence intervals (CIs). The [chi square] test and p-value were calculated for homogeneity between the four wards, and the relative risk to an error was evaluated.

Ethical considerations

Ethical approval was obtained from the university associated with the hospital. The Medunsa Research Ethics Committee approved the study (MREC/H/225/2014: PG). Permission to perform this study at the tertiary academic hospital was obtained from the hospital's chief executive officer. All data were collected anonymously. Patient confidentiality was maintained by the allocation of a unique study number to each participant.



During the study period, 227 patient medication charts (47 neonates and 180 paediatric patients) were evaluated for medication errors. A total of 91 patients were female (40%) and 136 patients were male (60%). The ages of the patients were categorised according to paediatric terminology developed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [19] Therefore, the study consisted of the following percentages: infants (8%, n=15), toddlers (17%, n=31), early childhood (28%, n=50), middle childhood (39%, n=71), early adolescence (7%, n=12), and one late adolescence. The median age of the patients was 5 years (interquartile range (IQR) 2-8 years, range 1 month - 19 years) and the neonates' mean age was 33 (standard deviation (SD) 3.89; range 25-40) weeks.

Patient diagnoses and medicines prescribed

The main causes of hospitalisation were respiratory distress syndrome, neonatal sepsis, babies born to HIV-positive mothers, B-cell acute lymphoblastic leukaemia, neonatal jaundice, adenotonsillectomy, tuberculosis and pneumonia. The most commonly prescribed medications were paracetamol, tilidine, amikacin, allopurinol, amoxicillin-clavulanic acid, benzylpenicillin, cloxacillin, ibuprofen, metronidazole, nevirapine and piperacillin-tazobactam.

Incidence and nature of medication errors

In total, 663 medication errors were detected among 227 patient files studied over 16 weeks, with one or more errors in 177 (78%) patients and no errors in 50 (22%) patients. The incidence of medication errors in the four paediatric wards was 2.9 per patient, per admission, over the 16-week observation period.

Origin of medication errors

A total of 715 medications were prescribed and studied over the 16-week study period. There were 309 (47%) prescribing errors documented, with an overall prescribing error rate of 43% (95% confidence interval (CI) 39.6-46.9). The nurses were responsible for 338 administration errors (51%), including labelling errors, giving an overall administration error rate of 47.3% (95% CI 43.6-50.9). The pharmacy was responsible for 16 dispensing errors (2%).

Site of medication error

Medication errors in the four paediatric wards were separately analysed (Table 3). The incidence of medication errors was tested using the [chi square] test of homogeneity. It was used to determine whether frequency counts were distributed identically across the different paediatric wards. The results showed no homogeneity, meaning that the four wards differed in respect of the percentage of errors (p<0.0001). The relative risk for medication errors was calculated using the number of medications observed and the incidence of errors per ward. The orthopaedic ward had the highest risk for medication errors compared with the other three wards.

Types of medication errors

The types of medication errors observed are shown in Fig. 1. Incorrect dose was the most frequent type of error that occurred, giving an overall incorrect dosing error rate of 34% (95% CI 30.5-37.7) in 663 errors detected. This was followed by omission of medication 19% (95% CI 15.5-21.4), medication given at the incorrect time 12% (95% CI 9.2-14.1), incorrect frequency of administration 7.9% (95% CI 5.8-9.9) and inadequate preparation of medication 7.8% (95% CI 5.7-9.7). Other types of errors found were mislabelling (6.7%), incorrect medication (4%), no route of administration prescribed (3.2%), incorrect duration of therapy (1.7%) and no frequency prescribed (1%). Examples of medication errors observed, and possible causes or reasons are shown in Table 4.

Groups of medications with errors

The most commonly prescribed medications for the four wards included anti-infectives and analgesics. The number of errors associated against the number of medication orders with these two classes are displayed in Fig. 2. Anti-infectives with the most errors, accountable for 284 (43%) of the 663 errors, were: amoxicillin-clavulanic acid, metronidazole, cloxacillin, cefuroxime, amikacin, benzylpenicillin, imipenem, piperacillin-tazobactam and gentamicin. Analgesics accountable for 166 (25%) of the errors were: paracetamol, tilidine and ibuprofen. The remaining 213 (32%) errors consisted of different medications from multiple classes. Paracetamol had the most medication errors, with 106 errors out of the total medication errors identified.

Categorising medication errors

Medication errors were classified into six categories (A-F) in the 177 patients with medication errors, according to severity (Table 2). [1] Just more than 60% (118) of the patients who had medication errors did not suffer any harm (categories A-C), whereas 59 (33%) patients had some level of harm (categories D-F). No permanent patient harm or deaths were recorded owing to a medication error.


In this study, the largest proportion of patients was toddlers and children in their early and middle childhood. The majority of the neonates included in this study were premature. Patients were mostly hospitalised owing to respiratory distress syndrome (in neonates), adenotonsillectomy and tuberculosis (in paediatrics). Anti-infectives and analgesics were the most prescribed classes of medication and correlates with similar studies that also identified these agents as commonly prescribed in paediatrics. [7,11,13,14]

The majority of studies conducted in paediatrics reporting medication errors declared medication error frequencies of between 11% and 54%. [2,4,7,8,14] This is markedly lower than the frequency of medication errors 78%) reported in this study.

Although the frequency of medication errors in this study is high' a number of factors may have led to biased findings' which actually resulted in an overall conservative estimate of errors reported. Firstly, although the doctors and nurses were unaware of the reasons for the observation' they were aware that they were being observed and might have changed their behaviour. Secondly, the research team tried to avoid as many interventions as they could to prevent observer-induced bias. However, in terms of the ethical principle of nonmaleficence, it would be unethical to allow medication administration errors to occur for the purpose of observation when it can cause direct, severe or irreversible harm. The researchers therefore had to intervene and prevent some errors from happening in cases where an observed error could cause harm to the patient. Examples of interventions by the researchers included the doctor being asked to change the high dose of 1 g paracetamol prescribed for a 2-year-old, to the recommended 180 mg, and the nurse being stopped before administering 12 drops of tilidine to a 1-year-old instead of two drops as prescribed. Lastly, the lack of observation of medication reconstitution and medication administration by nurses, 24 hours per day, 7 days per week, probably reduced the number of errors detected.

In the evaluation of the origin of medication errors, administration of medicines by nurses caused just over half (51%) of all detected errors, with prescribing errors by doctors causing 47% of the medication errors. There is some variation in the literature with similar results reported by Khalili et al. [7] and lower percentages in various other studies that ranged between 11.7% and 19% administration errors, and 11% and 34% prescribing errors. [2,8,13,14] Dispensing errors amounted to 2% of the total errors, which may be due to the fact that most commonly prescribed medications are kept in the ward as ward stock.

The most prevalent type of error identified was incorrect dosing (34%), followed by omission (19%) and medication given at the incorrect time (12%). Possible reasons for omission and incorrect time could include nursing staff being tasked with a number of non-nursing related duties, e.g. cleaning, admixture of medications and insertion of IV lines. This is consistent with similar studies that have also reported dosing errors. [3,4,6,7,14] Miller et al. [20] had remarkably high incidences in both omission of medication (42%) and the wrong time of administration (50%), corresponding to Chua et al.[13] and Hicks et al. [6]

Inadequate knowledge, insufficient training and increased workload has been listed as major causes of medication errors. [4,6,9,13] Similar findings were identified as the most prominent causes of medication errors in this study, miscalculation of dosages (26%), failure to monitor therapy (15%) and procedures (e.g. antibiotic policy) not followed (15%).

The paediatric orthopaedic ward had the highest risk for medication errors, even though they had the lowest number of medications prescribed and administered. Reasons for this included the high number of analgesics prescribed for postoperative pain relief. Tilidine is frequently prescribed for pain relief in this ward. Medication errors observed included omission of doses and incorrect dosing of the agent. Tilidine is administered using an oral medicine dropper, with the possibility of drops being administered inconsistently (i.e. too fast or too slow). [21] Small differences in the administration of this drug may result in either a lack of optimal pain relief (underdose) or harm (overdose). [21]

In the class of analgesics, paracetamol, tilidine and ibuprofen were identified as agents that caused the most errors. The literature pertaining to paracetamol is contradictory, with one study listing only five doses of paracetamol with errors [13] and other studies listing many errors. [7,9,14] Slightly less than half (43%) of all medication errors were identified in the class of anti-infectives and is equal to studies that found numerous errors in antibiotics reported in paediatrics. [3,9-11,13]

The greatest majority (87%) of these medication errors that reached the patients did not cause harm according to the categories used by the NCC MERP. [1] Alternative studies showed similar results, except where circumstances or events that had the capacity to cause harm were not included)[6,14]

Study limitations and recommendations

Only those errors observed by the researchers were used for analysis. Therefore several errors may have gone undetected. Other study limitations included validation of the tool used to determine error. Our tool was developed using reputable references.

Observation per se may also affect practice and result in a decrease of medication error rate. Observer bias could not be ruled out since observational research requires a lot of resources and referencing, and is time consuming.

Using a medication error checklist is fundamental to improve patient safety. It is therefore crucial for healthcare providers to identify weak points in the healthcare system regarding medication prescribing, administering and dispensing in paediatrics. Measures that may be implemented include a clinical pharmacist actively working with other healthcare providers in paediatric wards. This can improve the patient's healthcare outcomes and has been described in several studies. Reviewing patient medical charts and reporting medication therapy problems to the head of the medical team on a daily basis are part of the clinical pharmacist's daily responsibilities. [2,7,9,12,13,17]

Recommendations to reduce medication errors in the future include the implementation of training for paediatric nurses' doctors and pharmacists on aspects identified as part of the study' for e.g. steps to correct prescribing' how to reconstitute medication, and how to calculate dosages. Since medication preparations and administrations are the last line of defence against medication errors' an electronic medication error platform should be implemented to record and report medication errors.


This study showed that the frequency of medication errors in the paediatric ward of the teaching hospital was higher than that reported in similar studies elsewhere. Administration followed by prescription are the most error-prone steps in the paediatric medication process. Dosing errors are a common problem in paediatrics and, therefore, a formalised system to monitor errors should be introduced. Regular discussions on preventative measures among the multidisciplinary team should be initiated to further reduce the frequency of the errors. This study serves to create awareness and interest concerning medication safety in the paediatric population of SA.

[1.] National Coordinating Council for Medication Error Reporting and Prevention. NCC MERP, 2014. (accessed 28 January 2014).

[2.] Ghaleb MA, Barber N, Franklin BD, Wong ICK. The incidence and nature of prescribing and medication administration errors in paediatric inpatients. BMJ 2010; 95(2):113-118.

[3.] Jain S, Basu S, Parmar VR. Medication errors in neonates admitted in intensive care unit and emergency department. Indian J Med Sci 2009; 63(4):145-151.

[4.] Lerner RB, de Carvalho M, Vieira AA, Lopes JM, Moreira MA. Medication errors in a neonatal intensive care unit. Jornal de Pediatria 2008; 84(4):166-170.

[5.] Jhanjee A, Bhatia MS, Srivastava S. Medication errors in clinical practice. Delhi Psychiatry J 2011; 14(2):205-210.

[6.] Hicks RW, Becker SC, Krenzicheck D, Beyea SC. Mediation errors in the PACU: A secondary analysis of MEDMARX findings. J PeriAnesth Nurs 2004; 19(1):18-28.

[7.] Khalili H, Farsaei S, Rezaee H, Dashti-Khavidaki S. Role of clinical pharmacists' interventions in detection and prevention of medication errors in a medical ward. Int J of Clin Pharm Pharm Care 2011; 33(2):281-284.

[8.] Otero P, Leyton A, Mariani G, Cernadas JMC. Medication errors in pediatric inpatients: Prevalence and results of a prevention programme. J Am Acad Pediatr 2008; 122(3):737-743.

[9.] Wong ICK, Wong LYL, Cranswick NE. Minimising medication errors in children. Arch Dis Child 2008; 94(2):161-164.

[10.] Ross LM, Wallace J, Paton JY. Medication errors in a paediatric teaching hospital in the UK: Five years operational experience. BMJ 2000; 83(6):492-497.

[11.] Feleke Y, Girma B. Medication administration errors involving paediatric inpatients in a hospital in Ethiopia. Trop J Pharm Res 2010; 9(4):401-407.

[12.] Clifton-Koeppel R. What nurses can do right now to reduce medication errors in the neonatal intensive care unit. Newborn Infant Nurs Rev 2008; 8(2):72-82.

[13.] Chua SS, Chua HM, Omar A. Drug administration errors in paediatric wards: A direct observation approach. Eur J Pediatr 2009; 169(5):603-611.

[14.] Martines-Anton A, Sanchez IJ, Casanueva L. Impact of an intervention to reduce prescribing errors in a pediatric intensive care unit. Intensive Care Med 2012; 38(9):1532-1538.

[15.] Mehta U, Dheda, M, Steel G, et al. Strengthening pharmacovigilance in South Africa. S Afr Med J 2014; 104(2):104-106.

[16.] Maigetter K, Pollock AM, Kadam A, Ward K, Weiss, MG. Pharmacovigilance in India, Uganda and South Africa with reference to WHO's minimum requirements. Int J Health Pol Manag 2015; 4(5):295-305.

[17.] Simpson JH, Lynch R, Grant J, Alroomi L. Reducing medication errors in the neonatal intensive care unit. BMJ 2004; 89(6):480-482.

[18.] National Department of Health (NDoH). National Core Standards for Health Establishments in South Africa. Tshwane: NDoH, 2011. (accessed 10 October 2015).

[19.] Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Pediatric Terminology: Current efforts. 2015. (accessed 20 November 2015).

[20.] Miller MR, Robinson KA, Lubomski LH, Rinke ML, Pronovost PJ. Medication errors in paediatric care: A systemic review of epidemiology and an evaluation of evidence supporting reduction strategy recommendations. Qual Saf Health Care J 2007; 16(2):116-126.

[21.] Bauters T, Claus B, Willems E, et al. What's in a drop? Optimizing strategies for administration of drugs in paediatrics. Int J Clin Pharm 2012; 34(5):679-681.

A Truter, BPharm, MPharm; N Schellack, BCur, BPharm, PhD (Pharmacy); J C Meyer, BPharm, MSc (Med), PhD (Pharmacy)

Department of Pharmacy, Faculty of Health Sciences, School of Health Care Sciences, Sefako Makgatho Health Sciences University, Pretoria, South Africa

Corresponding author: A Truter (

Caption: Fig. 1. Types of medication errors across the four paediatric wards.

Table 1. Classification of types of medication errors

Type of error                Definition of error

Inadequate preparation of    When medication was prepared
medication                   or manipulated incorrectly. This
                             includes incorrect method of
                             reconstitution or dilution, not
                             shaking the suspension thoroughly
                             and crushing of specially coated

Incorrect dose               Dose that was prescribed or
                             administered was >10% above or
                             below the correct dose based on the
                             patient's weight.

Incorrect duration           Medication administered for a longer
                             period of time than was prescribed,
                             or prescribed medication that was
                             not discontinued when indicated.

Incorrect frequency          Medication administered at incorrect
                             intervals (e.g. 8-hourly instead of

Incorrect medication         Administration of medication
                             that was not prescribed, misread
                             prescription, or medication
                             administered to the wrong patient.

Incorrect time               There was >1 h difference between
                             the scheduled time and time of

Mislabelling                 When reconstituted medication was
                             kept in storage and had no label
                             indicating the time of reconstitution
                             and volume of diluent used. Infusion
                             not labelled with the name or
                             dose of medication that was being

Omission                     Failure to administer a prescribed
                             medication, or medication that was
                             being administered without noting
                             that it had been dispensed.

Prescribing error (e.g. no   Elements of good prescribing
route)                       practice were observed and each
                             medication prescribed was evaluated
                             for compliance with pharmacy
                             legislation as stipulated in Good
                             Pharmacy Practice, i.e. the correct
                             name, dosage, units, route, frequency
                             and duration of treatment.

Table 2. Categorising medication errors

Error and category   Harm and description

No error             No harm

  Category A         Circumstances or events that have the
                     capacity to cause harm

Error                No harm

  Category B         Error occurred but did not reach the

  Category C         Error occurred and reached the patient but
                     did not cause harm

  Category D         Error occurred and reached the patient
                     --required monitoring to confirm that it
                     resulted in no harm to the patient and/or
                     required intervention to preclude harm

Error                Harm

  Category E         Error occurred--need for treatment or
                     intervention--temporary harm to patient

  Category F         Error occurred--need for prolonged
                     hospitalisation--temporary harm to

  Category G         Error occurred that contributed to
                     permanent patient harm

  Category H         Error occurred that required intervention
                     necessary to sustain life

Error                Death
  Category I         Error occured that resulted in patient death

Table 3. Frequency of errors in the four paediatric wards

Ward           observed, n   Errors, n   [chi square]   p-value

Orthopaedics   87            113         44.68          <0.0001 *
Surgery        251           259
Oncology       241           185
NICU           136           106

Ward           risk

Orthopaedics   1.299
Surgery        1.032
Oncology       0.768
NICU           0.779

* Highly statistically significant.

Table 4. Examples of medication errors observed,
possible causes and reasons

                  Frequency of
Type of error     error (n=663)   Description of examples

Incorrect dose    226             1 g paracetamol prescribed
                                  instead of 180 mg (researcher

                                  5 mL paracetamol syrup given
                                  as 500 mg tablet

                                  150 mg metronidazole prescribed
                                  as 60 mg

                                  2 drops tilidine given as 12
                                  drops for 8-month-old
                                  (researcher intervened)

Omission          122             Common medications not given:
                                  paracetamol, tilidine and

                                  The nurse forgot to order
                                  antibiotics from the pharmacy
                                  that is not part of ward
                                  stock, patients missed doses

                                  Drip not inserted, patient
                                  failed to receive intravenous
                                  (IV) medication

Incorrect time    77              Prescription sent later to the
                                  pharmacy, received antibiotics
                                  at the incorrect
                                  time--administered at the
                                  wrong time

                                  Medication given at 14h00
                                  instead of 10h00

                                  One nurse for four babies--
                                  increased workload (drips to
                                  be inserted, admixtures, nappy
                                  changes, cleaning, updating
                                  files, etc.)

Incorrect         52              Cloxacillin given 8-hourly
frequency                         instead of 6-hourly, as

                                  Imipenem prescribed as
                                  6-hourly for all neonates
                                  instead of 12-hourly or
                                  8-hourly when <21 days of age

Inadequate        51              Oral amoxicillin-clavulanic
preparation/                      acid mixed with tap water
incorrect                         (sterile water available) Used
technique                         one needle to reconstitute all
                                  IV medication for the ward

                  Possible causes or               Cause or reason, %
Type of error     reasons (n)                      (95% CI)

Incorrect dose    Miscalculation (175), e.g.       26.4 (23.0-29.8)
                  dose prescribed was
                  incorrectly calculated based
                  on patient's weight or

                  Dose to be administered was
                  miscalculated due to limited
                  strength available

Omission          Failure to monitor (97), e.g.    14.7 (11.9-17.3)
                  prescription not checked to
                  see what must be administered

                  Medication out of stock, no
                  communication with doctor to
                  prescribe an alternative

                  No documentation (64) Rule of
                  thumb: if it was not signed it
                  was not administered

Incorrect time    Increased workload (68), e.g.    10.3 (8.0-12.6)
                  one nurse for 10 patients or
                  one nurse for four babies

                  Responsible nurse too busy
                  with administration and other

                  Not enough nursing staff in
                  the ward (understaffed)

Incorrect         Procedure not followed (96),     14.5 (11.8-17.2)
frequency         e.g. prescription not
                  double-checked for frequency

                  Antibiotic policy not followed
                  when prescribing antibiotics
                  in the neonate

Inadequate        Inexperienced staff (67) e.g.    10.2 (7.8-12.4)
preparation/      nursing students and new
incorrect         nursing staff Does not consult
technique         the package insert or other
                  reference sources of

                  Tired after working multiple
                  12- hour shifts

Fig. 2. Classes of medications with the number of times
it was ordered and the number of medication errors observed.

Classes of medications with the most errors

                  Medication orders   Medication errors

Anti-infectives   195                  284
Analgesics        214                  166

Note: Table made from bar graph.
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Article Details
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Title Annotation:RESEARCH
Author:Truter, A.; Schellack, N.; Meye, J.C.
Publication:South African Journal of Child Health
Article Type:Report
Geographic Code:6SOUT
Date:Mar 1, 2017
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