Hypocholesterolemic 3[beta]-benzyl-4-methyl-4-aza-5[alpha]-cholestane methiodide.
The more potent hypocholesterolemic steroids developed were the 4,4-dimethyl-4-aza-cholestanes with nitrogen at position four. The most active of these was 3[beta]-benzyl-4-methyl-4-aza-5[alpha]-cholestane methiodide. Evidence was obtained that it acts by at least two of the proposed possible mechanisms. It appears that this quaternary salt is absorbed because of its in vivo activity. It had been postulated that bulk around the quaternary nitrogen produced by the benzyl group might provide sufficient lipid solubility for absorption. The synthesis as well as in vitro and in vivo data will be presented..
Norman J. Doorenbos, Dept. Pharmacal Sci., Auburn Univ., Auburn, AL 36849 and Masako Nakagawa, Hokkaido Univ., Saporro, Japan.
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|Title Annotation:||Health Sciences|
|Author:||Doorenbos, Norman J.|
|Publication:||Journal of the Alabama Academy of Science|
|Article Type:||Brief Article|
|Date:||Apr 1, 2003|
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