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Hybrid technique provides alternative for varicose veins.

CHICAGO -- A technique that combines occlusion coils and alcohol sclerosis is the latest addition to the array of catheter-based approaches available to treat varicose veins.

"We have yet another tool in an area where I don't think we needed another tool; it's coil occlusion and sclerosis," Dr. Thom W. Rooke, head of vascular medicine at the Mayo Clinic, Rochester, Minn., said at a symposium on vascular surgery sponsored by Northwestern University. "It's definitely a feasible alternative to stripping or other catheter ablation mechanisms."

Potential advantages include no tumescent anesthesia and no potential for thermal skin damage. Radiofrequency and laser technologies have the potential--despite the use of tumescent anesthesia--to cause thermal injury, particularly in patients with relatively thin skin or in whom the veins are very superficial; they also have the potential to produce clots in the saphenous vein that may propagate into the femoral vein with the attendant risks of pulmonary embolism.

The new procedure is relatively simple and easy to incorporate, if the practitioner is already using fluoroscopy and catheterization in the daily routine. "And the final punch line: This [procedure] may be very cost effective, although we haven't analyzed that yet," he said.

Dr. Rooke reported results from a retrospective study of 96 patients (mean age 53 years) with incompetent saphenous veins, in whom the use of coil occlusion and sclerosis resulted in complete occlusion of the target vein in 94% of 119 limbs, and partial occlusion in the remaining 6%.

Nearly all patients were being treated for significant symptoms, such as discomfort/pain, edema, stasis changes, and ulceration, rather than for cosmetic indications.

Venous refilling rates dropped from a preprocedural mean of 11.6 mL/minute per 100 g (which corresponds to "moderate" venous incompetence at the Mayo Clinic), to a "normal" value of 5.4 mL/min per 100 g after the outpatient procedure.

At a mean follow-up of 14 weeks, symptoms were resolved or markedly improved in 94% of patients, were partially improved in 4%, and showed no change in 2%.

A small, asymptomatic arteriovenous fistula in the region of the saphenofemoral junction was observed on follow-up ultrasound in one patient; two patients developed symptomatic superficial phlebitis; and none developed deep venous thrombosis, said Dr. Rooke, professor of vascular medicine at the Mayo Medical College, also in Rochester. In three limbs, the coils were inappropriately placed and had to be repositioned.

Interventional radiologists have been using various occlusion coils and sclerosing agents (typically ethanol) for decades to successfully and safely obliterate arteriovenous malformations, varicoceles, and other unwanted veins, so their application to varicose veins seemed a logical extension to physicians at the Mayo Clinic, Dr. Rooke explained.

After radiographic confirmation of occlusion has been obtained, lidocaine (3 cc of 1% solution) is injected into the lumen of the vein and allowed to sit for a few minutes. The catheter is then slowly withdrawn, and ethanol (1-6 mL) is infused throughout the length of the saphenous vein.

Finally, the catheter is withdrawn, and full-length, graduated compression stockings are applied to the leg. The stockings should be worn continuously for 3 days, followed by daytime-only usage for about 10 days. Patients can ambulate immediately after the procedure, with no limitations placed on their routine, Dr. Rooke said.

In some cases, sodium tetradecanal sulfate (3%) was used instead of absolute alcohol because there are anecdotal reports of toxicity, especially to the lungs, with ethanol, Dr. Rooke said in an interview. However, most of the clinic's radiologists, who are more familiar with the alcohol, have returned to using ethanol as their preferred agent.

Coil occlusion and sclerosis have also been used to treat perforator veins and the shorter saphenous vein, with good results, he added. Dr. Rooke reported that he had nothing to disclose with regard to this research.

BY PATRICE WENDLING

Chicago Bureau
14-Week Results of Hybrid Technique for Varicose Veins

Patients' symptoms resolved or markedly improved 94%
Partial improvement 4%
No change 2%

Note: Based on a retrospective study of 96 patients with incompetent
saphenous veins at a mean age of 53 years.
Source: Dr. Rooke
ELSEVIER GLOBAL MEDICAL NEWS

Note: Table made from pie chart.
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Title Annotation:Dermatology
Author:Wendling, Patrice
Publication:Internal Medicine News
Geographic Code:1USA
Date:Mar 1, 2008
Words:689
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