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How Fat Works.


The obesity epidemic striking industrialized nations has led to a renewed research focus on the physiological causes and effects of excess fat in the body. Scientists are striving to understand how fat is metabolized and how excess fat leads to diseases such as diabetes. Wood, a metabolic geneticist at the University of Alabama at Birmingham, outlines his and others' recent findings on such topics. Much of that research uses mice engineered to lack certain genes that control the buildup of fat. Using these animal models of obesity, scientists have learned much about how cells both store fat and secrete hormones that regulate a person's appetite and activity levels. Wood describes how discoveries in these areas are explaining disorders of metabolism, cholesterol processing, and insulin activity. The book explores the merits of various dietary approaches, exercise, and lipid-lowering drugs. Harvard, 2006, 272 p., b&w illus., hardcover, $35.00.
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Title Annotation:book review
Publication:Science News
Article Type:Book Review
Date:Feb 25, 2006
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