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Highly pathogenic porcine reproductive and respiratory syndrome virus, Asia.

To the Editor: Recently, the novel and highly virulent variant of porcine reproductive and respiratory syndrome virus (PRRSV), which first emerged in the People's Republic of China and Vietnam in 2006 (1), has rapidly spread in pigs in Southeast Asia. The affected countries include Bhutan, Cambodia, Laos, Malaysia, Myanmar, the Philippines, Thailand, and Singapore. In eastern and northern Asia, South Korea and Russia were also reported to be affected (2) (Figure). The epidemic affected not only large commercial farms but also the backyard industry, which created a serious problem for the global swine industry and for food safety. In February 2011, the Veterinary and Animal Breeding Agency in Ulaanbaatar, Mongolia, confirmed an outbreak of porcine reproductive and respiratory syndrome (PRRS) (3). Nearby neighbors, such as Japan, North Korea, Indonesia, and other Asia-Pacific countries, are also at risk.

PRRS was first reported in the United States in 1987. The disease causes reproductive failure during late-term gestation in sows and respiratory disease in pigs of all ages. In 2006, a new, highly pathogenic PRRS emerged, characterized by high fever (41[degrees]C-42[degrees]C), skin discoloration/ reddening, high incidence of illness (50%-100%), and high proportion of deaths (20%-100%) in pigs of all ages. This new PRRS has spread throughout the swine industry in China, resulting in the culling of an estimated 20 million pigs annually in 2006-2007 in China (4). PRRSV is a member of the family Arteriviridae in the order Nidovirales, which also includes severe acute respiratory syndrome coronavirus.

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PRRSV is a single-stranded positive sense RNA virus that shows high rates of genetic diversity. In the genome of the novel highly pathogenic PRRSV mutant, 4 deletions (2 deletions in nonstructural protein 2, one deletion in the 5' untranslated region, and one deletion in the 3' untranslated region), and some other point mutations, have occurred, which were markedly different from those found in any other previous virus isolate.

After a surveillance study of the epidemic and an analysis of >300 novel highly pathogenic PRRSVs were conducted, the highly pathogenic PRRSV from China was considered to have gradually evolved from CH-1a, a local PRRSV isolate. The evolutionary path could be traced through intermediate PRRSV strains (5). Moreover, we found that highly pathogenic PRRSV has a further enlarged deletion in nonstructural protein 2.

Highly pathogenic PRRSV first emerged in China and Vietnam almost simultaneously in 2006, and the epidemic focus was in the area between southern China and northern Vietnam (6, 7). Although no evidence has shown that the highly pathogenic PRRSV isolate from China or Vietnam has spread in other areas, highly pathogenic PRRS has spread throughout the Malaysian Peninsula to southern Russia.

In addition, all highly pathogenic PRRSV isolates share high sequence identity and have the same deletions as the highly pathogenic PRRSV isolated from China or Vietnam. PRRSV can spread through a variety of routes, including direct contact between pigs, droplet contact through nasal secretions, direct contact with saliva and feces, and indirect contact.

PRRS has spread rapidly around the world through pig sales, semen, and airborne transmission, including from airline passengers who carry the virus on their clothing, shoes, or equipment while traveling (8). In the global market, any virus emerging in the highly pathogenic form is a threat. The risk of highly pathogenic PRRS spreading to other countries is increasing.

This study was supported by grants from the National Natural Science Foundation of China (nos. 30901080, 31001050) and National Postdoctoral Science Foundation (nos. 20090451026, 201003467).

DOI: http://dx.doi.org/10.3201/eid1709.110411

References

(1.) Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C, et al. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE. 2007;2:e526. doi:10.1371/journal. pone.0000526

(2.) World Organisation for Animal Health. World Animal Health Information Database Interface [cited 2009 Aug 15]. http:// www.oie.int/wahis/public.php

(3.) Pig Progress [cited 2011 Feb 22]. http://www.pigprogress.net/pig-diseaseoutbreak-news/mongolia-vet- agencyconfirms-prrs-outbreak-7079.html

(4.) An TQ, Tian ZJ, Xiao Y, Li R, Peng JM, Wei TC, et al. Origin and evolutionary path of the newly emerged highly pathogenic porcine reproductive and respiratory syndrome virus in China. Emerg Infect Dis. 2010;16:365-7.

(5.) Feng Y, Zhao TZ, Nguyen T, Inui K, Ma Y, Nguyen TH, et al. Porcine reproductive and respiratory syndrome virus variants, Vietnam and China, 2007. Emerg Infect Dis. 2008;14:1774-6. doi:10.3201/ eid1411.071676

(6.) Normile D. Virology. China, Vietnam grapple with "rapidly evolving" pig virus. Science. 2007;317:1017. doi:10.1126/ science.317.5841.1017

(7.) Lv J, Zhang J, Sun Z, Liu W, Yuan S. An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome. J Gen Virol. 2008;89:2075-9. doi:10.1099/ vir.0.2008/001529-0

(8.) Albina E. Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview. Vet Microbiol. 1997;55:309 16. doi:10.1016/S0378-1135(96)01322-3

Author affiliations: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin City, People's Republic of China (T.-Q. An, Z.-J. Tian, C.-L. Leng, J.-M. Peng, G.-Z. Tong); and Shanghai Veterinary Research Institute, Shanghai, People's Republic of China (G. Z. Tong)

Address for correspondence: Guang-Zhi Tong, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518 Ziyue Rd, Minhang District, Shanghai 200241, People's Republic of China; email: gztong@ shvri.ac.cn
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Author:An, Tong-Qing; Tian, Zhi-Jun; Leng, Chao-Liang; Peng, Jin-Mei; Tong, Guang-Zhi
Publication:Emerging Infectious Diseases
Article Type:Letter to the editor
Geographic Code:90ASI
Date:Sep 1, 2011
Words:919
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