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Higher dose vitamin D needed for fracture prevention.

A pooled analysis of 11 clinical trials reported in a recent issue of the New England Journal of Medicine reveals a protective effect for high dose vitamin D supplementation against the risk of fracture in older men and women.* While 800 IU or more of the vitamin was associated with reduced fracture risk, lower doses did not appear to be effective.

Scientists analyzed data from 31,022 individuals age 65 and older who were assigned to receive oral vitamin D or a placebo in one of 11 randomized, controlled trials. Among those whose vitamin D was among the top 25% of subjects at a median dose of 800 IU per day, there was a 30% lower adjusted risk of hip fracture and a 14% lower risk of nonvertebral fractures in comparison with those whose vitamin D intake was lowest.


* N Engl J Med. 201 2 Jul 5;367(1):40-9.

Editor's Note: The study found no fracture-preventive benefit for doses lower than 800 IU per day, indicating that higher doses may be needed, particularly among those at risk for osteoporosis and fracture. This study publishes what Life Extension has already used to rebut government recommendations against vitamin D.

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Title Annotation:IN THE NEWS
Author:Dye, D.
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Oct 1, 2012
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