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High-dose folate may protect against damage caused by heart attack.

High-dose folic acid provides significant protection against the damaging effects of myocardial infarction (heart attack) in rats, according to a new report. *

Scientists pretreated rats with 10 mg folic acid/day or placebo for one week prior to inducing myocardial infarction and then restoring blood flow.

Folic acid-treated rats had less heart muscle dysfunction and lower levels of damaging superoxide than placebo recipients. During the simulated heart attack, ejection fraction (amount of blood pumped by the heart) dropped to 27% in the placebo group, but remained near normal at 73% in the folic acid group. Areas of heart tissue death in the treated group were less than 10% the size of those in the control group.

These findings suggest that folate acts as a cardiac energy reserve, "providing much needed energy for muscle contraction, in the form of ATP, at the same time the heart is being starved for oxygen-carrying blood by a blocked artery."


* Moens AL, Champion HC, Claeys MJ, et al. High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces post-reperfusion injury. Circulation. 2008 Apr 8;117(14):1810-9.
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Title Annotation:IN THE NEWS
Author:Dye, Dayna
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Jul 1, 2008
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