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High homocysteine doubles heart disease risk.


A high level of homocysteine in the blood is an "independent and important risk factor" for coronary artery disease in a high-risk population, roughly equal to the risk posed by elevated cholesterol and triglyceride levels, report Chinese researchers. *

Scientists studied 237 patients admitted for coronary angiography, an imaging procedure to identify blockages in the arteries supplying blood to the heart. Patients were divided into two groups: 138 who had been diagnosed with existing coronary disease, and 99 who were found to be normal. They were then assessed for a wide range of potential cardiovascular disease risk factors, including: blood pressure, cholesterol levels, triglycerides, high-sensitivity C-reactive protein (hs-CRP), and plasma homocysteine.


The study revealed that high homocysteine levels roughly doubled a patient's risk of coronary artery disease. Furthermore, statistical analysis showed hs-CRP, total cholesterol, and systolic blood pressure to be independent risk factors for coronary artery disease, while high-density lipoprotein (HDL) had a protective effect.


* Ni M, Zhang XH, Jiang SL, Zhang Y. Homocystinemia as an independent risk factor in the Chinese population at a high risk of coronary artery disease. Am J Cardiol. 2007 Aug 1;100(3):455-8.
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Title Annotation:In The NEWS
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Brief article
Geographic Code:9CHIN
Date:Dec 1, 2007
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