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High [O.sub.2] blood reperfusion may salvage tissue. (Pilot Study).

SNOWMASS, COLO. -- Reperfusion using hyperoxygenated blood may increase myocardial salvage after an acute myocardial infarction, Dr. David O. Williams said at a conference sponsored by the American College of Cardiology.

The hyperoxygenated reperfusion therapy is provided for 90 minutes following reestablishment of coronary flow via percutaneous intervention. The goal is to limit reperfusion injury and the no-reflow phenomenon whereby damage to the coronary microvasculature interferes with blood flow to myocardial tissue despite successful relief of the coronary occlusion, said Dr. Williams, professor of medicine at Brown University Providence, R.I.

The therapy is being developed by TherOx, an Irvine, Calif., company TherOx's proprietary AO System creates a saline mist of aqueous oxygen that is mixed with arterial blood at a ratio of 25 parts blood to 1 part aqueous oxygen. The resulting hyperbaric arterial blood has a [PO.sub.2] of 700-1,000 mm Hg, compared with just 100 mm Hg for normal arterial blood.
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Author:Jancin, Bruce
Publication:Internal Medicine News
Article Type:Brief Article
Date:Aug 1, 2002
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