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Heptares Therapeutics' calcitonin gene-related peptide (CGRP) antagonist nominated for preclinical studies for migraine.

M2 EQUITYBITES-May 18, 2017-Heptares Therapeutics' calcitonin gene-related peptide (CGRP) antagonist nominated for preclinical studies for migraine


Heptares Therapeutics stated on Thursday that its preclinical candidate calcitonin gene-related peptide (CGRP) antagonist in partnership with Teva has been nominated for advancement into further preclinical studies as an investigational treatment for migraine.

Migraine is the recurring attacks of moderate to severe headache pain and is typically one-sided, throbbing and worse with activity.

Under the terms of the licensing and drug-discovery agreement, the nomination of this small-molecule candidate has triggered a USD5m payment from Teva to Heptares

This small-molecule candidate was discovered by Heptares using its structure-based design approach in partnership with Teva. The nominated compound emerged from a rigorous Teva candidate selection process and has a highly differentiated profile from other investigational small-molecule CGRP antagonists, representing the first milestone in a partnership to generate novel candidates for the treatment of episodic and chronic migraine.

According to the companies, Calcitonin gene-related peptide (CGRP) is released during migraine attacks and can trigger migraine in patients. CGRP is found in small to medium-sized neurons in the trigeminal ganglion and mediates its activity through G protein-coupled receptors located throughout the body. Elevated levels of CGRP are found in people with migraine during an attack and blocking CGRP activity is a validated mechanism of action for relieving pain, and also for preventing migraine.

Heptares is a clinical-stage company and part of Sosei Group Corporation (TSE Mothers Index:4565), a biopharmaceutical company originating from Japan.

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Publication:M2 EquityBites (EQB)
Date:May 18, 2017
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