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Heard of a ' biological bypass'?

A NEW method of growing arteries could lead to a " biological bypass" or a non- invasive way to treat coronary artery disease.

Coronary arteries get blocked with plaque, leading to a decrease in the supply of blood and oxygen to the heart. Over time this blockage can lead to heart attack, while severe blockages in multiple major vessels may require coronary artery bypass graft surgery.

Researchers at the Yale School of Medicine have reported in the Journal of Clinical Investigation preliminary success of a new method to grow new arteries in mice and zebrafish. Instead of using a growth factor -- proteins that stimulate the growth of cells -- to grow new arteries as done by scientists in the past with no success, Yale researchers simulated arterial formation by switching on and off two signaling pathways.

This, they say, opens up the possibility of developing a new class of medication to grow new arteries.

The next step is to test this finding in a human clinical trial.

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Publication:Mail Today (New Delhi, India)
Date:Mar 18, 2010
Words:181
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