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H. pylori and Skin.

Patients with several treatment-resistant skin conditions had significant improvement when treated for Helicobacter pylori infection, Dr. Mikihase Sakurane reported in a poster presentation at the annual meeting of the Society for Investigative Dermatology.

Among patients with an intransigent condition who were treated for H. pylori infection in addition to receiving regular dermatologic therapy, 50%-70% improved, including some who achieved complete resolution, said Dr. Sakurane of Wakayama (Japan) Medical College, describing the dermatology department's anecdotal experience.

Dr. Sakurane randomly selected 144 patients with skin conditions resistant to standard therapy and tested them for IgG antibody to H. pylori. Of these, 92 (64%) had evidence of H. pylori infection.

The H. pylori test was positive in 65% of both patients with chronic urticaria and cutaneous pruritus, 73% of those with nummular dermatitis, 85% of patients with prurigo chronica multiformis, and 100% of those with erythroderma.

Eradication of H. pylori was confirmed by endoscopic examination and a urea breath test.

Of the 26 patients with chronic urticaria, treatment of H. pylori was associated with complete resolution in 6 (23%) patients. Symptoms were controlled later with antihistamine therapy in 13 (50%) patients, Dr. Sakurane said.
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Author:Kubetin, Sally Koch
Publication:OB GYN News
Date:Nov 15, 2000
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