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H. pylori and Pancreatic CA.

Men who test positive for cytotoxin-associated gene A-positive (CagA+) strains of Helicobacter pylori infection are at increased risk for pancreatic cancer, reported Rachael Z. Stolzenberg-Solomon, Ph.D., of the National Institutes of Health, Bethesda, Md., and her associates.

The investigators conducted a nested case control study of more than 29,000 Finnish men who participated in the AlphaTocopherol, Beta-Carotene Cancer Prevention Study. They identified 121 men who developed pancreatic cancer between 1985 and 1995 and 226 case-matched controls. All subjects were smokers.

Stored serum samples were submitted to enzyme-linked immunoassay analysis and indicated that 82% of the men with pancreatic cancer and 73% of the controls had H. pylori infections. The CagA+ strain was present in 60% of cases and 51% of controls (J. Natl. Cancer Inst. 93[12]:937-41, 2001).
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Title Annotation:disease association
Author:Kubetin, Sally Koch
Publication:Internal Medicine News
Geographic Code:1USA
Date:Sep 1, 2001
Words:131
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