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Green tea extract may not help fight cancer.

Green tea is often drunk by people in hopes of warding off cancer, heart disease and immune system ailments, but it may be a misconception that supplements made from concentrated tea extract will multiply those benefits.

A study completed by University of Mississippi researchers indicates that extremely high doses of green tea extract actually may activate rather than shut down--genetic mechanisms that help certain tumors survive and grow.

"Drinking green tea is still good for you," said Yu-Dong Zhou, a molecular biologist at the university's National Center for Natural Products Research. "There are thousands of years of evidence on that, but the idea of taking the equivalent of hundreds of cups of tea a day is something that needs to be looked at carefully."

Zhou is principal investigator on a study that examined the effect of high doses of the active ingredients in green tea extract on hypoxia-inducible factor-1, or HIF-1, a key regulator of how tumor cells adapt to low-oxygen conditions. The results were published in a recent issue of the Journal of Natural Products.

In recent years, several manufacturers have produced dietary supplements containing concentrated extracts of green tea's active ingredients. The compounds are not toxic in large doses, but high concentrations may not necessarily be healthful, explained Dale Nagle, associate professor of pharmacognosy in the UM School of Pharmacy who worked with Zhou on the project. Many commercial supplements provide far more of the active compounds than a person could obtain by simply drinking tea.

"Nearly all the evidence of the beneficial effects of green tea comes from studies on populations who consume green tea, not tea extract in the form of powder, concentrates or pills," Nagle explained. "There is no direct evidence that taking reasonable quantities of these green tea products is toxic. But the issue here is whether these extremely high doses are really beneficial.

"The fact that the green tea ingredient known as ECG activates HIF-1--which can have different effects depending on the type of tumor--means it may not have the desired effect that people think they're getting."

The active compounds in green tea could actually serve dual functions, inhibiting HIF-1 at low concentrations and activating it at higher doses, Zhou said.

"At low concentrations, it doesn't seem to have this potentially negative effect as we saw in the lab," she said. "A lot more study needs to be done to see what the outcome will be in people who take high doses of these compounds."

"In theory, this effect on HIF-1 could suppress some early forms of tumors but may actually help other tumors--especially some of the more aggressive ones--survive and grow," Nagle said.
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Title Annotation:World News: Coffee and Tea Reports from the Front Line
Publication:Tea & Coffee Trade Journal
Geographic Code:1USA
Date:May 20, 2005
Previous Article:Can you really sober up with coffee?
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