Printer Friendly

Gouty arthritis.


A 40-year-old man presented to the clinic with complaints of left knee pain. His medical history included an 18-year history of gouty arthritis and on and off treatment for the same. He used to take nonsteroidal anti-inflammatory drugs for occasional pain in both feet. He also took allupurinol along with nonsteroidal inflammatory drugs during acute attacks of joint pain and prophylaxis up to the age of 35 years.

On examination of the left knee, there was no effusion. Knee movements were clinically normal. Multiple small nodules were seen on the dorsum of the left hand with a 2-x-3 cm large nodule over the base of the third metacarpal. They were not warm, not tender, and cystic to firm in consistency and the underlying extensors tendons were free. The skin over the nodules was normal and pinchable. There was no discharging sinus or ulcer noted.

Multiple tophaceous deposits, grayish discoloration, and hallux valgus deformity were noted on the great toe on both sides. A large localized swelling was seen in the retrocalcaneal region of this patient that was cystic in nature, not warm and tender and free from the tendo calcaneus.

Erythrocyte sedimentation rate was 25 mm in the first hour (normal <14). The patient's blood parameters revealed hemoglobin 11.2 gms, TLC 7,500/cu mm. Complete blood counts, C-reactive protein, liver function tests, creatinine, electrolytes, and thyroid function test and protein electrophoresis were normal. Tests for antinuclear body, rheumatoid factor, and HLA-B27 were negative. Serum uric acid was 4.1 mgs (normal 3-7 mgs). Ultrasound KUB was normal. Urine examinations were normal.


Radiograph of the wrist (Figure 1) showed a circular punched-out lytic lesion involving scaphoid, capitate, and trapezoid bones. Metacarpals and phalanges were normal. A radiograph of the feet revealed a classic 'punched-out' lytic lesion, marginal erosions, and an associated overhanging edge at the distal metatarsals.



Straw colored fluid was aspirated from both the retrocalcaneal region and left wrist dorsal swelling. Microscopic examination and culture for aerobic, anaerobic, acid fast, and fungal organisms were negative. Needle-shaped urate crystals were seen with few RBC's in between (Figure 2). Pus cells were not seen.

He was treated with nonsteroidal anti-inflammatory drugs, protected weight bearing, and physiotherapy. Four weeks after the visit, he had improved, with decreased pain and increased movement.


There were multiple small nodules and a large nodule on the dorsum of left hand at the base of 3rd metacarpal (Figure 1), a localized cystic granuloma in the retrocalcaneal region is shown, and multiple tophaceous deposits over the 1st metatarsophalangeal joint and hallux valgus deformity are seen.


The radiograph (Figure 2) shows a 'Scalloping sign' in capitate and a punched-out lytic lesion involving the scaphoid, capitate, and trapezoid bones. The radiograph provides (Figure 3) anteroposterior views of both feet demonstrating punched-out lytic lesions in the 1st metatarso-phalangeal joints with marginal erosions in the metatarsal head.

Aspirate of hand and retrocalcaneal region shows needle shaped urate crystals (Figure 4). The image shows needle shaped Monosodium urate crystals and flat, plate like colorless uric acid crystals with numerous RBC's. No pus cells were seen.


Gouty arthritis. However, calcium pyrophosphate dehydrate deposition disease (CPPD) and rheumatoid arthritis are the differential diagnoses, which need to be evaluated both clinico-radiologically and with a histopathological examination.


Deposition of gouty tophi in the hand occurs relatively late in the disease and is uncommon with good medical management. (1) Radiographic manifestations of gouty arthritis may precede symptoms in up to 25% of patients and may precede deposition of gouty tophi in up to 42%. (2) Gouty arthritis has various modalities of presentations in the hand. This includes acute suppurative flexor tenosynovitis, (1,3) carpal tunnel syndrome, (1,4) and a localized painful mass in the midpalm, (5,6,7) tophi over the dorsal aspect of the interphalangeal and metacarpophalangeal joints. (1,2,5) Neglected cases can produce intratendinous infiltration, flexion contractures, tendon rupture, and skin ulceration in extreme cases. (3,6)

Gouty tenosynovitis in the hand can be present without tophi or previous involvement of upper extremity. (3) Often called "the imitator," gout may masquerade as septic arthritis, rheumatoid arthritis or neoplasm, and the diagnosis is often delayed by weeks or months.

Gout can rarely coexist with rheumatoid arthritis, (8) but it is perhaps more frequently misdiagnosed as rheumatoid arthritis because of its proliferative synovitis (3) and because 10% to 20% of patients with rheumatoid arthritis have elevated uric acid levels.

The early radiological signs of gout are joint effusion and periarticular edema, caused by the deposition of the nonopaque crystals within the synovial and cartilaginous tissues. (5,6,7) Radiographic examination eventually reveals a classic 'punched-out' lytic lesion with an associated overhanging edge at the distal metatarsals. (6) Multiple marginal erosions and decreased joint space are seen at several metacarpal-phalangeal joints. These erosions contain sclerotic borders. (7)

Osteopenia and the loss of joint space are usually not seen until advanced disease stages. (6) Additionally, the advanced stage is also characterized by joint destruction and severe deformities. Proliferative osseous change, intraosseous cysts, chondrocalcinosis, and olecranon bursitis can occasionally be seen in the patients with gout. (5)

The diagnosis of gout should not be based on laboratory values alone. Joint or tenosynovial aspiration, Gram stain, and examination under polarized light is 85% sensitive for the diagnosis of gout and may be helpful in differentiating acute gouty tenosynovitis from rheumatoid arthritis or infection. (2)

The asymmetry and lack of joint space narrowing not seen until advanced stages allow differentiation from other similar-appearing disorders (eg, psoriasis, osteoarthritis, infection, and rheumatoid arthritis). CPPD can have symptoms resembling that of gout and can also occur concomitantly in up to 40% of patients with gout. (9)

Our patient who was on long duration of treatment for gouty arthritis presented to our clinic with nonspecific knee pain and an incidental radiological evaluation of left hand showed the involvement of carpal bones. The literature on gout is huge and refers, not specifically, to every joint. The fact that the carpus has not been extensively described constituted a base for our presentation. Histological examination demonstrated urate crystals from the aspirate of hand and retrocalcaneal region and confirmed the carpal involvement.


Gouty arthritis can also occur in carpal bones. It can occur alone or along with or without the associated findings. One should always have a high index of suspicion. Systematic, good clinical examination and proper radiographs should be carried out. Histology confirms the diagnosis. Carpal involvement in gouty arthritis should also be kept in the differential diagnosis in any case of unusual lytic lesions in carpal bones.

Gouty arthritis has various presentations in the hand. They include acute tenosynovitis, carpal tunnel syndrome, tophi deposition in the palm, punched-out lytic lesions; and involvement of the metacarpals. Carpal bones are rarely involved. This case showed the involvement of carpal bone. One should be careful in interpreting hand radiographs. A systematic clinical examination along with radiographs and aspiration cytology confirms the diagnosis.


(1.) Moore JR, Weiland AJ. Gouty tenosynovitis in the hand. J Hand Surg [Am]. 1985;10:291-295.

(2.) Barthelemy CR, Nakayama DA, Carrera GF, et al: Gouty arthritis: A prospective radiographic evaluation of sixty patients. Skeletol Radiol. 1984;11:1-8.

(3.) Abrahamsson SO. Gouty tenosynovitis simulating an infection: A case report. Acta Orthop Scand. 1987;58:282-283.

(4.) Janssen T, Rayan GM. Gouty tenosynovitis and compression neuropathy of the median nerve. Clin Orthop Mar. 1987;216:203-206.

(5.) Zayas VM, Calimano MT, Acosta AR, et al. Gout: The radiology and clinical manifestations. Appl Radiol. 2001;30:15-23.

(6.) Uri DS, Dalinka MK. Crystal disease. Radiol Clin North Am. 1996;34:359-364.

(7.) Becker MA. Clinical aspects of monosodium urate monohydrate crystal deposition disease (gout). Rheum Dis Clin North Am. 1988;14: 377-394.

(8.) Atdjian M, Fernandez-Madrid F. Coexistence of chronic tophaceous gout and rheumatoid arthritis. J Rheumatol. 1981;8:989-992.

(9.) Lagier R, Boivin G, Gerster JC. Carpal tunnel syndrome associated with mixed calcium pyrophosphate dihydrate and apatite crystal deposition in tendon synovial sheath. Arthritis Rheum. 1984;27:1190-1195.

J. Terrence Jose Jerome, MBBS

Dr. Jerome prepared this case while completing his postgraduate studies in orthopedics in the Department of Orthopedics, St. Stephen's Hospital, Tiz Hazari, Delhi, India.
COPYRIGHT 2012 Anderson Publishing Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2012 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Jerome, J. Terrence Jose
Publication:Applied Radiology
Article Type:Case study
Geographic Code:9INDI
Date:Jun 1, 2012
Previous Article:Right renal vein varix.
Next Article:Roadmap to cloud-based PACS.

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |