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Ginger in chemotherapy.

Pillai AK, Sharma KK, Gupta YK, Bakhshi S. 2011. Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer 56:2;234-8.

Nausea and vomiting are major adverse effects of chemotherapy. Ginger (Zingiber officinale) has been used in postoperative and pregnancy induced nausea and vomiting however data on its ability to reduce these side effects in children and young adults is lacking.

This study evaluated bone sarcoma patients over 60 chemotherapy cycles of cisplatin/doxorubicin. Patients were randomised to ginger root powder capsules or placebo capsules as an additional antiemetic to ondensetron and dexamethasone in a double blind design. Acute chemotherapy induced nausea and vomiting (CINV) was defined as nausea and vomiting occurring within 24 hr of start of chemotherapy (days 1-4) and delayed CINV as that occurring after 24 hr of completion of chemotherapy (days 5-10).

Acute moderate to severe nausea was observed in 28/30 (93.3%) of the cycles in the control group compared with 15/27 (55.6%) cycles in experimental group (P = 0.003). Acute moderate to severe vomiting was significantly more in the control group compared with the experimental group, 23/30 (76.7%) vs. 9/27 (33.33%) respectively (P= 0.002). Delayed moderate to severe nausea was observed in 22/30 (73.3%) cycles in the control group compared with 7/27 (25.9%) in the experimental group (P < 0.001). Delayed moderate to severe vomiting was significantly more in the control group compared with the experimental group, 14/30 (46.67%) vs. 4/27 (14.81%) (P = 0.022).

Authors concluded that the ginger root powder was effective in reducing the severity of acute and delayed CINV as an additional therapy to ondensetron and dexamethasone in patients receiving high emetogenic chemotherapy.

Tessa Finney-Brown MNHAA

tessafinneybrown@gmail.com
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Author:Finney-Brown, Tessa
Publication:Australian Journal of Medical Herbalism
Geographic Code:8AUST
Date:Jun 22, 2011
Words:309
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