Gestational diabetes: perinatal and maternal complication in 24-28 weeks.
Gestational diabetes mellitus (GDM) is a glucose tolerance disorder that occurs or is diagnosed for the first time during pregnancy and is one of the most common pregnancy complication.  The prevalence of GDM has increased in all racial/ethnic groups. 
During the next 2 decades, the world population is expected to increase by 37%, but the prevalence of diabetes would increase by 114%. More bothersome is a 151% projected increase in number of people with diabetes vis a vis just a 40% projected increase in population of India during the same period. 
In GDM, perinatal morbidity is more and, in the long-term, women with GDM have an almost sevenfold increased risk of developing type 2 diabetes after pregnancy.  Gestational impaired glucose tolerance (IGT) is also associated with both pregnancy complications and subsequent diabetes and cardiometabolic risk. 
It is therefore highly important that these mothers are diagnosed during pregnancy, and that they have a regular postpartum follow-up for identification and treatment of any complications.
The factors that have been postulated to influence the risk of GDM among mothers include a positive family history of diabetes, treatment for infertility, recurrent, urinary tract infections, macrosomic infant, unexplained neonatal death, prematurity, pre-eclampsia, diabetes in previous pregnancy, and advancing maternal age. 
But race/ethnicity and obesity are the two strongest independent risk factors for GDM. Asians and Philippines are most effected races while blacks are least vulnerable.  It is also seen that Asians had a higher reported prevalence of diabetes at lower BMI levels than all other racial/ethnic groups. 
However, the demographic distribution of obesity (highest among African Americans and lowest among Asians) does not mirror the demographic distribution of GDM (lowest among African Americans and highest among Asians) --might be due to interference of other confounding factors like race/ ethnicity.
Even the definition of obesity is debated. The World Health Organization proposed a BMI cutoff of 23.0 kg/[m.sup.2] for overweight among Asians in 2000, compared with a cutoff of 25.0 kg/[m.sup.2] for non-Asian populations.
The same is true for the definition of GDM--if Asians have higher post-challenge glucose levels than other race/ethnic groups, it is possible that the current screening method for diagnosing GDM, a 50-g post challenge test, may favor diagnosis among Asians across BMI categories (which could have been lower if fasting blood sugar level is included as a criteria). 
In addition to higher risk of perinatal morbidity, the offspring of mothers with GDM face increased risk of childhood obesity and early onset of type 2 diabetes mellitus. GDM is a condition that can be effectively controlled, thereby decreasing the associated risks, and eventually leading to the delivery of healthy infants.
Uttar Pradesh is the largest state in India with a population of 230 million and expectedly 4.5 million pregnancies every year. Added to this, is the fact that this state has one of the highest maternal mortality rate of 359 per lakh, just second to Assam at 390--national average being 212!  Side by side, infant mortality rate too in Uttar Pradesh is one of the highest in the country. Infant mortality rates (IMR) is defined as the number of deaths of children less than one year of age per 1,000 live births. It is 53 for Uttar Pradesh, against national average of 42--just as the fourth ranker following behind the first three rankers viz. Madhya Pradesh (56), Assam (55) and Orissa (53)!  The MMR and IMR might be having its causation, at least partially, in the GDM. Thus, appropriate management of GDM will improve both maternal and perinatal outcomes too. 
Primary objective of this study was to determine the prevalence of GDM and evaluate the maternal and fetal outcome in and around Kanpur. Thus, this study was undertaken to know the extent of burden on the healthcare, before scope of intervention could be defined.
Materials and Methods
A prospective study from September, 2012 to October, 2014 was done at 198 healthcare facilities in antenatal mothers and 24,656 mothers were screened in their 24th to 28th weeks of pregnancy by impaired oral glucose tolerance test (OGTT), as per guidelines of Diabetes in Pregnancy Study Group India (DIPSI) and Federation of Obstetric and Gynecological Societies of India (FOGSI).
DIPSI has prescribed a single test procedure to diagnose GDM in the community and it measures only 2 hours post-glucose (75 gm) > 140mg/ dl by GOD-POD method to screen positive for GDM. 
This cascading effect is advantageous as this would not result in false-positive diagnosis of GDM. This single-step procedure has been approved by Ministry of Health, Government of India and also recommended by WHO. Advantages of the DIPSI procedure are :
* Pregnant women need not be fasting
* Causes least disturbance in a pregnant woman's routine activities
* Serves as both screening and diagnostic procedure.
Performa Accu check Glucometer from Roche were used and 75 gm Glucose Packets were prepared at our own center and distributed along with glucometers and strips, lancets, glass, spoon etc to all 198 Reporting health facilities.
Out of these 198-139 were in private hospitals and 59 in government health facilities including CHCs (Community Health center), PHCs (Primary health Center), UHP (Urban health Post), D-type center, UFWCs (Urban family Welfare Centres), District hospitals and other 4 major hospitals in Public sector.
Criteria for exclusion from the study were as follows:
* unwilling to participate in the study
* twin pregnancy/ abnormal lie or other known complications
* known cases of diabetes even before conception
* un-accessible in the given period of 24th to 28th week of gestation.
First of all, demographic profile of the GDM and non-GDM patients like age, BMI, nationality, parity, family history of diabetes, blood pressure and OGTT results were noted.
During the total study period of September, 2012 to September, 2014, > 55,000 women were supposed to be registered for pregnancy on 198 health centers in and around Kanpur, Uttar Pradesh, India.
By the end of the year of study in September, 2013--18,556 pregnancies were personally screened in this study with confirmed 2,517 cases of GDM (a prevalence of 13.6%).
It was found that > 94% pregnant women in Uttar Pradesh do not know about GDM. Yet, more than 70% reporting women in Uttar Pradesh now receive at least one antenatal Care, and out of these reporting women, 67% deliveries are institutional deliveries.
Out of 24, 656 pregnancies screened by December, 2013--3,561 were screened positive on OGTT (as per DIPSI guideline)--thus the recent most prevalence of GDM was found to be 14.42%. After application of exclusion criteria, 856 patients were finally followed--for whom, age and BMI matched 900 controls were also selected for parallel comparative assessment.
Stillbirth, Perinatal & neonatal mortality were respectively 2, 3.3 & 6 times higher in GDM, compared to non-GDM. Most of the GDM positive cases were observed in the very first pregnancy i.e. primigravida cases (62%). Congenital Malformation was 8 times higher in GDM Women compared to Non-GDM. Low Birth Weight (LBW) was 35% in GDM Compare to 16% in Non GDM, which was significantly different--showing an increased relative risk for LBW in GDM. It's notable that LBW is a major cause of neonatal death and contributes in infant mortality rate and may be a confounding factor in calculation of isolated association.
Malformation in women with GDM is significantly higher compare with Non GDM case. GDM positive cases had 20.6% positive family history of diabetes. Mean blood pressure did not differ significantly in pregnant women with or without GDM. Among those who were diagnosed with GDM, rates of perinatal mortality, still births, neonatal deaths, congenital malformation, large for gestational age (LGA), cesarean section, post birth unit (PBU) care, jaundice were significantly higher compare to those without gestational diabetes.
Event of maternal mortality, Low birth weight and pregnancy induced hypertension (PIH) were not statistically significantly different, although PIH was 5.1% in gestational diabetes group and 3% in Non GDM group.
Perinatal mortality increased with Increase in Blood Sugar (OGTT) value and Perinatal mortality reduced significantly in Intervention with Diet and exercise compare with history of perinatal mortality.
Though, non-pharmacological preventative therapy may not always be possible because of age, presence of various diabetic complications (hypertension, heart disease, retinopathy), and comorbid conditions (osteoarthritis, obesity). 
It was also found in our study that out of 16 stillbirths, 7 had pre-gestational diabetes and blood sugar OGTT value was > 200 mg %, while remaining 9 had blood sugar between 140 mg% to 200 mg%. Congenital malformation was significant cause of perinatal mortality. One maternal death was observed in GDM and Non GDM group each.
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with the onset or first recognition during pregnancy with or without remission after the end of pregnancy.  Compared to European women, the prevalence of gestational diabetes has increased 11-fold in women from the Indian subcontinent. 
Appropriate diagnosis and management of GDM can improve maternal and perinatal outcome. Many studies have been done in various parts of India on gestational diabetes, like Seshiah et al. in Chennai, Wahi et al. in Jammu, and Gajjar in Baroda, Gujarat. [12-14]
Perinatal outcomes associated with poor glycemic control in mothers are associated with as high as 42.9% mortality.  In our study it was found to be as low as 6.1%, which might be due to strict follow up and awareness programs running in parallel and all complicated cases excluded right in the beginning.
In another study conducted in the nearby state of Rajasthan, the prevalence of GDM was 6.6% compared to our 14.42%, which might be due to different criteria of screening added by cultural and geographical differences. 
But more intuitively, the difference of this vastness is vested in single abnormal value approach as it is used in this study as per DIPSI guidelines, compared to the 3 values of OGTT. The difference is clearly elicited by such variation of the criteria as seen in a study form Haryana. 
While this study reports 10.87% GDM prevalence based on single abnormal value, the prevalence goes down to 7.1%, if all the three values are required to be abnormal.  Even a study from Japan agrees that new adaptation of criteria with a single aberrant value (mostly 2 hour post prandial), the prevalence estimates are expected to rise nearly 4 fold! 
Compared to the 1999 criteria of FPG [greater than or equal to] 126 mg/dL and/or 2hPG [greater than or equal to] 140 mg/dL, a recent 2013 criteria recommends a 75-g oral glucose tolerance test (OGTT) cut-off as follows :
* fasting plasma glucose (FPG) [greater than or equal to]92 mg/dL,
* 1-hour plasma glucose (1hPG) [greater than or equal to]180 mg/dL,
* and 2-hour plasma glucose (2hPG) [greater than or equal to]153 mg/dL.
Thus this new criteria has a lower cut-off for FPG, higher cut-off for 2hPG, and also the addition of 1hPG values. If the criteria of 2 hours postprandial glucose level have been used, the prevalence of GDM in our study would have gone much lower.
Moreover, a study in Illawara region showed that Indian were worst hit with 11.9% prevalence rate  which rose to 16.7% in another study  For preventive purposes, such an over-diagnosis by single abnormal value can be more welcome.
Positive family history for diabetes was seen in 20.6% GDM cases compared to just 6.5% non-GDM cases. The outcome is comparable to a study in which 31.7% of women with GDM had a positive family history of diabetes, compared with 12.8% in normal women. 
Pregnancy related complications were more common in GDM compared to non-GDM cases as seen in perinatal death (neonatal death as well as stillbirth), congenital malformation, caesarean section, PBU (intensive care) admissions, macrosomia, low birth weight, preeclampsia and jaundice incidences.
This outcome is comparable to many other studies. For example, in a study, women with GDM were more likely to develop pregnancy-induced hypertension, preeclampsia, antepartum hemorrhage, preterm labor, and caesarean delivery than those without GDM. 
Infants born to women with GDM in this study were at increased risk of being born preterm and were also significantly more likely to be macrosomic and birth trauma was significantly higher in offspring of GDM mothers. 
In yet another study, for the gestational diabetes mellitus group, adjusted odds ratios for hypertensive disorders during pregnancy, induction of labor and emergency caesarean section were 2.7, 3.1 and 2.5 respectively. For Apgar score <7 at 5 min, need for neonatal intensive care >1 day and large-for-gestational age infant adjusted odds ratio was 9.6, 5.2 and 2.5 respectively. 
In a study comparable to ours, Women with a diagnosis of GDM had significantly higher levels of emergency caesarean section (odds ratio 1.75), their infants had significantly higher levels of neonatal unit admission (odds ratio 3.14) and costs of care were 34% greater than in women without GDM. Other variables that significantly increased costs were weight, age, primiparity, and premature delivery. 
The strategy that has the greatest likelihood of being cost-effective is dependent on the risk of gestational diabetes mellitus (GDM) for each individual woman. When GDM risk is less than 1% then the no screening/treatment strategy is cost-effective. 
Where risk is between 1.0% and 4.2% fasting plasma glucose followed by OGTT is most likely to be cost-effective; and where risk is greater than 4.2%, universal OGTT is most likely to be cost-effective. However, acceptability of the test alters the most cost-effective strategy. 
Incidence of GDM in the studied Indian population is 14.42% which relies on DIPSI recommendation--based on other screening criteria, this value varies considerably. Moreover, confusion concerning 'an efficiently predictive screening criteria' still remains an issue. The outcome of pregnancy, in terms of mother as well as baby, is expectedly far worse with GDM. Awareness concerning GDM and its possible morbid outcomes among mothers is very low (6%) and can be a target area to improve the outcome.
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Source of Support: Nil
Conflict of interest: None declared
Rajesh Jain (1), Rakesh R Pathak (2), Aditya A Kotecha (3)
(1) Project Manager, Gestational Diabetes Prevention Control Project-Kanpur Nagar, Uttar Pradesh, India
(2) Department of Pharmacology, GMERS Medical College, Dharpur, Patan, Gujarat, India
(3) Medical Officer at Giriraj Hospital, Rajkot, Gujarat, India
Correspondence to: Rakesh R Pathak (email@example.com)
Received Date: 12.07.2014
Accepted Date: 29.07.2014
Table-1: Perinatal mortality in GDM versus non-GDM in pregnancy GDM Rate Non GDM Rate (N=856) (N=900) Still births 24 2.8% 12 1.33% Neonatal deaths 28 3.2% 5 0.55% Total Perinatal deaths 52 6.1% 17 1.9% P value RR OR Still births <0.0418 2.103 2.13 (1.06-4.29) Neonatal deaths <0.0001 5.888 6.05 (2.32-15.75) Total Perinatal deaths <0.0001 3.216 3.36 (1.92-5.85) Table-2: Maternal and Foetal outcome in GDM versus non-GDM mothers GDM Non-GDM P (N=856) (N=900) Value Stillbirths 24 (2.80%) 12 (1.33%) 0.0449 Neonatal Deaths 28 (3.27%) 5 (0.55%) 0.0001 Perinatal Deaths 52 (6.07%) 17 (1.88%) 0.0001 Congenital Malformation 16 (1.87%) 2 (0.22%) 0.0005 Caesarean Section 445 (51.99%) 369 (41.00%) 0.0001 PBU care 82 (9.58%) 10 (1.11%) 0.0001 LGA 11 (1.29%) 1 (0.11) 0.0027 LBW 302 (35.28%) 140 (15.55%) 0.0001 Preeclampsia 44 (5.14%) 27 (3.00%) 0.0290 Jaundice 29 (3.39%) 7 (.77%) 0.0001 OR Stillbirths 2.13 (1.06-4.29) Neonatal Deaths 6.05 (2.32-15.75) Perinatal Deaths 3.36 (1.92-5.85) Congenital Malformation 8.55 (1.96-37.32) Caesarean Section 1.45 (1.2-1.75) PBU care 9.43 (4.85-18.31) LGA 11.7 (1.51-90.9) LBW 2.94 (2.18-3.96) Preeclampsia 1.75 (1.07-2.86) Jaundice 4.47 (1.95-10.27 Table-3: Perinatal Mortality as a function of Blood Sugar Value and its comparison with history of Previous Foetal loss Perinatal Mortality Blood sugar P Value value OGTT Present Previous 100-119 (n=283) 7 (3%) 7 (2.4%) 0.85 120-139 (n=317) 4 (1.26%) 12 (3.8%) 0.07 140-159 (n=445) 20 (4.5%) 111 (25%) 0.0001 160-179 (n=162) 11 (6.7%) 32 (20%) 0.0008 180-199 (n=95) 8 (8.4%) 15 (15.5%) 0.20 200->200 (n=154) 13 (8.4%) 21 (13.5%) 0.21 Table-4: Maternal and Foetal outcome in GDM versus non-GDM & Its Relationship with History of Previous birth complications GDM Previous P (N=856) Foetal Loss Value Stillbirths 24 (2.8%) 190 (22.2%) 0.0001 Neonatal Deaths 28 (3.27%) 18 (2.1%) 0.6005 Perinatal Deaths 52 (6.1%) 126 (14.72%) 0.0001 Congenital Malformation 16 (1.9%) 4 (0.47%) 0.11 Caesarean Section 445 (52%) 0 0 PBU care 82 (9.6%) 0 0 LGA 11 (1.3%) 0 0 LBW 302 (35%) 0 0 Pre- eclampsia 44 (5.1%) 0 0 Jaundice 29 (3.4%) 0 0 Non-GDM Previous P (N=900) Foetal loss value Stillbirths 12 (1.33%) 32 (3.6%) 0.0038 Neonatal Deaths 5 (0.55%) 3 (0.33%) 0.7364 Perinatal Deaths 17 (1.8%) 36 (4%) 0.0094 Congenital Malformation 2 (0.22%) 2 (0.22%) 0.6104 Caesarean Section 369 (41%) 0 0 PBU care 10 (1.1%) 0 0 LGA 1 (0.1) 0 0 LBW 140 (15.5%) 0 0 Pre- eclampsia 27 (3%) 0 0 Jaundice 7 (0.77%) 0 0 Figure-1: Pregnancy rank versus GDM cases Pregnancy Rank I 62 II 21.6 III 12.6 IV 1.3 V 1.3 VI 0.5 Note: Table made from bar graph. Figure-2: Family History of diabetes in GDM and non-GDM pregnancies Family History of Diabetes GDM 20.6 Non-GDM 6.5 Note: Table made from bar graph. Figure-3: BMI in GDM versus non-GDM pregnancies Underweight 10% Normal Weight 79% Overweight 8% Obesity 3% Note: Table made from pie chart. Figure-4: Feto-maternal outcome data Normal 30% Caesarean Section 52% Premature babies unit care 10% Preeclampsia 5% Jaundice 5% Note: Table made from pie chart.
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|Title Annotation:||RESEARCH ARTICLE|
|Author:||Jain, Rajesh; Pathak, Rakesh R.; Kotecha, Aditya A.|
|Publication:||International Journal of Medical Science and Public Health|
|Date:||Oct 1, 2014|
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