Printer Friendly

Gene therapy to prevent lung disease progression discovered.

Byline: ANI

Washington, Dec 22 (ANI): Boston University researchers have found a new gene therapy to thwart the progression of emphysema, a lung disease.

Alpha-1 Anti-trypsin Deficiency is the most frequently inherited form of emphysema found in young people due to a mutation in the Alpha-1 Anti-trypsin gene. This genetic disorder makes individuals susceptible to early emphysema and liver cirrhosis.

The team from Boston University School of Medicine (BUSM) experimented on mice and found a way to transport genes selectively to nearly 70 percent of a mouse lung's alveolar macrophages (AM), an important cell contributing to emphysema.

Senior author Darrell Kotton, MD, an associate professor of medicine and pathology and co-director, Center for Regenerative Medicine at BUSM, said: "We applied this novel approach to achieve sustained in vivo expression of normal human alpha-1 antitrypsin (hAAT) protein at levels able to ameliorate emphysema in mice.

"The lung macrophages carrying the therapeutic gene survived in the lungs air sacks for the two-year lifetime of the treated mice following a single intra-tracheal injection of the lentiviral vector we had engineered."

Kotton and his team used this method of gene transfer to get localized secretion of therapeutic levels of human alpha-1 antitrypsin (hAAT) protein in lung epithelial lining fluid.

Andrew Wilson, lead author of the study and an assistant professor of medicine at BUSM, said: "The progression of emphysema in mice exposed to elastase was significantly improved by the gene therapy as evidenced by improvements in lung compliance and alveolar size."

Wilson added: "Our results challenge the dogma that lung macrophages are short-lived and suggest these differentiated cells as a target cell that may be considered for in vivo gene therapy applications including the sustained correction of hAAT deficiency."

The study has been published online in the Journal of Clinical Investigation. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by Syndigate.info an Albawaba.com company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Dec 22, 2009
Words:315
Previous Article:Lily Allen's 'on and off' therapy after miscarriage.
Next Article:Ponting is still a fantastic batsman, says Farhat.
Topics:


Related Articles
Gene therapy: a new Rx for CF?
And downs.
Cystic fibrosis controversy: a new theory hints that gene therapy in the womb can cure disease.
Statins may slow lung impairment in smokers.
Scientists turn benign virus into good gene therapy carrier for cystic fibrosis.
Gene therapy could repair damaged lungs for transplant.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters