Printer Friendly

Gene tests: so far, so good.

Gene tests: So far, so good

The first U.S.-approved infusions of genetically engineered cells into humans have produced no significant ill effects and have begun to provide useful data, researchers told a National Cancer Institute (NCI) advisory board this week. To date, five terminally ill cancer patients have recieved the one-time doses of about 100 million gene-altered, tumor-fighting lymphocytes.

Scientists had initially obtained lymphocytes from patients' tumors, then inserted a bacterial "marker" gene into each cell in order to track the cells' survival and distribution in the body after reinfusion (SN: 5/27/89, p.324). NCI researcher Steven A. Rosenberg says tests so far indicate the cells begin to concentrate in tumors the fifth day and live and circulate in the body for at least 19 days.

Ultimately, the researchers hope to gain government permission to give patients cells engineered to secrete naturally occurring tumor-fighting compounds. At the meeting, Rosenberg revealed that he and colleagues have recently succeeded in engineering human lymphocytes to produce one such compound, tumor necrosis factor.
COPYRIGHT 1989 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1989, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:infusion of genetically engineered cells into humans
Author:Weiss, R.
Publication:Science News
Date:Sep 23, 1989
Previous Article:Alzheimer's protein not restricted to brain.
Next Article:Ozone: indoors may offer little protection.

Related Articles
A vaccine for all seasons; genetic engineering is remodeling the smallpox vaccine to provide immunity against many other diseases.
Engineered microbes stay close to home.
Blood vessels support engineered implants.
NIH panel okays human gene transfer test.
Human gene-splice test considered.
Additional human gene transfers sought.
Gene therapists told to do homework.
Reoviruses yield to gene rearrangement.
Monkey See, Monkey Glow.

Terms of use | Copyright © 2017 Farlex, Inc. | Feedback | For webmasters