Printer Friendly

Gastrointestinal and pancreatic neuroendocrine tumours and carcinomas; a review of rare tumour type.

Byline: Ayesha Siddiqa, Hatem Adel, Sohail Ahmed Khan, Farheen Huda and Amjad Sattar

Keywords: Neuroendocrine tumours, Carcinoid tumour, Carcinoid.


Neuroendocrine tumours (NETs) are a rare presentation of tumours that involve neuroendodermal cells. 1,2 These tumours are usually characterised by hormonal activity. Gastroenteropancreatic system, being the prime location, contributes almost 70% of all NETs, 2 broadly categorised into pancreatic neuroendocrine tumours (pNET) and enteric (extra-pancreatic) neuroendocrine tumours (eNET). 1 Other primary sites usually include bronchopulmonary segments, thyroid, adrenals, parasympathetic and sympathetic systems. 2 Genitourinary system is uncommonly involved. 3 A recent increase of approximately 20% has been observed in worldwide prevalence of NET primarily because of early detection with cross-sectional imaging and endoscopic ultrasound (EUS). 4-6 Pancreatic NETs comprise 1-2% of all pancreatic neoplasms with incidence of 1 in 100,000 persons. 6,7

Pancreatic NETs have predilection for vascular invasion resulting in tumour thrombosis, with portal vein being most commonly involved. 8 In the gastrointestinal (GI) tract, ileum is commonly involved in 30% cases 9,10 followed by rectum and appendix. Less commonly, stomach, duodenum and jejunum are involved. 10 Among regional trends, recently there was an increase observed in the diagnosis of NETs in India with the pancreas being the most common site of involvement. 11 Bukhari et al. reports that 22.8% of tumours in Pakistan are NETs with adrenal being the most common site involved. 12 NETs are classified into low, intermediate and high grade according to their mitotic index and Ki-67 index. 4 Low and intermediate are categorised into well-differentiated tumours and high grade as neuro endocrine carcinomas. 4,6,7 This review covers the aetiology, diagnosis, staging, imaging techniques, imaging features and treatment of these rare tumours that need prompt diagnosis.


Most of the NETs have a sporadic presentation. However, association of these tumours with multiple endocrine neoplasia type I (MEN-I) and "familial clustering" has also been reported. A diagnosis of pancreatic NET can be seen with heavy smoking. 13 However, conditions such as diabetes mellitus (DM), raised gastrin levels and ulcerative colitis have traditionally been associated with NETs. 14 Other complex phakomatoses such as von Hippel Lindau disease, tuberous sclerosis and neurofibromatosis type I have also been associated with this condition. 15,16 Gastrointestinal NETs are common in African-American population whereas Caucasians are affected usually by bronchial carcinoids. 17


Tumour location and clinical presentation are important for the diagnosis of gastroenteropancreatic NETs (GEP-NETs). Patients presenting with signs and symptoms of increased hormonal secretion need evaluation by laboratory assays. Specific hormonal assay need to be carried out for specific NET. 15,18,19 Chromogranin A is a serum marker used commonly for NETs, as its elevated levels are found in approximately 60% to 80% cases. 20 Histopathology is required for final diagnosis.

Histopathological Diagnosis

Exact histological features of NETs depend upon the location and cells of origin, but certain features are common. Macroscopically, these tumours have solid looking nodular or polypoidal appearance with whitish to grayish colour. 21 Microscopically, the tumour is composed of cells of round or oval nuclei having salt and pepper chromatin along with eosinophilic granular cytoplasm. Tumour nests are arranged in a sheet-like pattern. 21 Neuroendocrine carcinomas are classified as small or large cell carcinomas with small cell carcinomas having spindle shaped tumour cells with scanty cytoplasm and large cell carcinomas having medium to large tumour cells with atypical nuclei. 21

Role of Immunohistochemistry

The histopathological diagnosis of NET is confirmed by demonstration of immunohistochemical (IHC) neuroendocrine markers. Different known IHC markers include chromogranin, protein cell product 9.5, neural cell adhesion molecule, synaptophysin, neuron specific enolase and Leu. 7 To confirm the endocrine nature of the cells, chromogranin A and synaptophysin are commonly employed. Chromogranin A is found in the secretory granules of neuroendocrine cells. 22 Synaptophysin is the most sensitive and chromogranin A is the most specific marker. 23 When there is a presence of metastatic NET with an unknown primary, then use of IHC staining panel with homeobox protein CDX2, pancreatic and duodenal homeobox 1 (PDX1), insulin gene enhancer protein ISL-1 and thyroid transcription factor 1 (TTF1) can aid in identification of the primary origin of metastatic NET. 24


American Joint Commission on Cancer (AJCC) adopted a tumour, node, metastases (TNM) based staging system for all anatomic sites that is parallel to the TNM system established by European Neuroendocrine Tumour Society (ENETS). 25 Staging depends upon the size of tumour (T stage), extent of tumour invasion and tumour relation to other nearby anatomical locations. World Health Organisation (WHO) has classified NET according to their mitotic index and Ki-67 index. Tumours categorised as low grade have Ki-67 index of less than 3% and a mitotic rate 20/10 HPF. Intermediate grade tumours have a Ki-67 index ranging from 3% to 20% and a mitotic rate 2-20/10 HPF. 4

Imaging modalities

Ultrasound provides the baseline modality for the evaluation of solid abdominal organs. However, cross-sectional parameters, such as computed tomography (CT) and magnetic resonance imaging (MRI), play an imperative role in the accurate diagnosis and management of GEP-NETs. The details provided by these modalities help provide options for better surgical planning, further characterisation of disease extent and presence of metastasis.


The overall sensitivity of trans-abdominal ultrasonography (TUS) ranges 13-27% in diagnosing GEP-NET26. Bowel gas shadows limit the TUS evaluation of pancreatic body and tail. However, evaluation of liver metastasis by TUS has a high specificity, approximately ranging 92-100%. 26,27 Endoscopic ultrasound (EUS) has an advantage of using high probe frequency of 7.5-12 MHz and also close evaluation of the region of interest. 28 The reported rate of detection is 45-60% for enteric NETs and 80-100% for pancreatic NET. 29 However, it is operator-dependent and carries a narrow field of view.

Multidetector Computed Tomography

Multi-detector CT (MDCT) has a high spatial and temporal resolution and considered an initial imaging technique in suspected cases of abdominal pathology. 9 With its features of rapid speed, thin collimation and multi-planar reconstruction, it assists in surgical planning and further management. The use of focussed examination protocols makes it easier in getting fine anatomical details. 28,30 Calcification and haemorrhages are better appreciated in unenhanced phases followed by intravenous (IV) contrast administration. A multiphasic dynamic approach is feasible as NETs have metastasis that are hyper-vascular and show characteristic enhancement on early arterial phase of dynamic imaging.

Magnetic Resonance Imaging

MRI has superceded CT in terms of organ imaging and also for evaluation of metastasis. MRI has an overall sensitivity of 74-94% and specificity of 78-100%. 31,32 Dynamic contrast enhanced imaging along with fat-suppressed contrast-enhanced T1-weighted (T1W FAT-SAT) is advisable for a high accuracy. 31 Diffusion weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping serve as additional tool for non-hyper-vascular tumours. MR uses no ionising radiation and has better tolerability of contrast agents. MRI is particularly beneficial in patients with equivocal/negative findings CT/US. It may also be used as surveillance in younger patients at risk of developing the disease.

Somatostatin Receptor Scintigraphy/Octreotide Scan

An increased expression of somatostatin receptor (SSTR) at cell membrane is manifested by NETs, mostly by well-differentiated tumours. 33 Therefore, functional imaging targeting the receptors can be performed. Among the five subtypes of SSTR, SSTR-2 is expressed commonly. 33 Somatostatin analogues have a high affinity for tissues expressing SSTR and somatostatin receptor scintigraphy (SRS) commonly makes use of this property. Octreotide is a commonly used somatostatin analogue and labelled with indium 111 to diagnose the lesions that are receptor-positive by the help of scintigraphy and is considered the reference standard. 28 In one study, SRS had a greater sensitivity than any other conventional imaging technique for NET diagnosis. 34

Gallium Scan and Role of Positron Emission Tomography

Gallium-68 is a radioisotope that is produced from a 68 Ge/68 Ga generator. It is a positron emission tomography (PET) radioisotope. 68 Ga-DOTATATE, 68Ga-DOTANOC and 68 Ga-DOTATOC are the radiopharmaceuticals that are currently in use for imaging of neuroendocrine tumours overexpressing various SSTR subtypes. 68 Ga-DOTATOC PET has a sensitivity of 97%, specificity of 92% and a diagnostic accuracy of 96%. 34 68 Ga-DOTATOC PET is also superior to 111In-DTPA-octreotide SPECT in the detection of NET. 35 68 Ga-DOTANOC has also affinity for SSTR. 68 Ga-DOTATOC is more specific for SSTR-2, however, 68 Ga-DOTANOC has a selectivity for SSTR2, 3 and 5. 36 68 Ga-DOTANOC also has a favourable dose profile 37. 68 Ga-DOTANOC has high sensitivity in identification of small lesions, particularly found in liver, lymph nodes or bones. 38,39 68 Ga-DOTATOC and 68 Ga-DOTATATE are specific for SSTR-2, however, the affinity of 68 Ga-DOTATATE for SSTR-2 is almost 10 times higher.

A study comparing 68 Ga-DOTATOC with 68 Ga-DOTATATE concluded that both the radiotracers are comparable in diagnostic accuracy and higher affinity of 68 Ga-DOTATATE for SSTR-2 is not relevant clinically. 40

Imaging Features for Tumour Detection

Pancreatic Neuroendorcine Tumours

The characteristic appearance of pancreatic neuroendorcine tumours (pNETs) on ultrasound is that of a hypoechoic lesion with a hyperechoic halo around it. 28 On dynamic contrast-enhanced CT or MRI, they appear as solid tumours that show avid enhancement, typically on arterial phase (Figure 1). This enhancement indicates the rich capillary network of these tumours. 41,42 Smaller tumours usually appear homogeneous.

Larger tumours may appear heterogeneous and show areas of non-enhancement, indicating necrosis. Cystic degeneration, fibrosis and calcification may also be evident. 41,42 Pancreatic neuroendocrine carcinomas carry a poor prognosis and usually have an infiltrative appearance. Vascular invasion may be present. Metastases are usually also hyper-vascular and show hyper-enhancement. NET in peri-ampullary region usually present with pancreato-biliary obstruction (Figures 2-3).

Extra-pancreatic/Enteric Neuroendocrine Tumours

NETs of enteric origin approximately form around 67% of the cases. 10 Gastric NETs originate from enterochromaffin cells. They are an incidental finding on endoscopy and seen as multiple, small less than 1-2 cm sized polyps usually located in gastric fundus and body. 10 On multiphasic dynamic contrast-enhanced CT, extra-pancreatic/enteric neuroendocrine tumours (eNETs) are usually identified as sub-mucosal enhancing lesions (Figure 4). 10,43 Raised gastrin levels are common findings. 43 Endoscopic evaluation is advisable to localise the lesion and for histopathological evaluation, while CT and MR are used for the staging of disease. 29 Duodenal NETs are rare and account for approximately 2-3% of the cases. 9,10 They are usually an incidental finding on oesophago-gastro-duodenoscopy and are commonly located in the upper third of duodenum. Due to their intaluminal/intramural location and small size, these tumours are difficult to be demonstrated on CT and MRI. 10

When large, they usually manifest as hyper-vascular lesions which may be intaluminal polypoidal mass or intramural lesions. Endoscopy and biopsy is recommended for definitive diagnosis. Ileal NETs are responsible for about 26-30% of the cases, are usually sporadic and may be multiple. 44 Disease may present with hepatic metastases at the time of presentation. 10 On multiphasic dynamic contrast-enhanced CT, the main lesion may appear polyp-like or plaque-like. They usually show avid enhancement (Figure 5). 45 The primary lesion may contain calcification. 46 Mesenteric metastases are common with small bowel carcinoids and appear as spiculated/well-defined on CT. There is surrounding stranding fibrosis and radiating spicules representing desmoplastic reaction. This gives a characteristic "spoke wheel" appearance. 45 In the liver, metastases show avid enhancement on arterial phase and become isodense to liver parenchyma in the delayed phase.

Colonic NET are rare. They resemble adenocarcinoma and appear as poorly differentiated masses. Contrast-enhanced CT is essential for staging and typically shows a hyper-attenuating lesion. EUS better evaluates the adjacent rectal wall invasion. On dynamic contrast-enhanced MRI, NETs usually appear hyper-intense on T2WI and appear hypo-intense on T1WI. Post-contrast scan shows avid enhancement and variable heterogeneity in terms of necrotic/cystic component in poorly differentiated/aggressive tumour.28

Differential Diagnosis:

Pancreatic NETs

- Pancreatic ductal adenocarcinoma (typically hypo-vascular tumours, rarely show areas of calcification, usually encases/infiltrates superior mesenteric artery and coeliac trunk, involves common bile duct).

- Metastasis.

- Paraganglioma.

Gastric NETs

- Oat cell carcinoma.

- Sclerosing mesenteritis.

- Desmoplastic carcinoma.

- Lymphoma.


Regardless of the site of origin of tumour, complete surgical resection is the first line of treatment and is potentially curative. 47 Surgical approach is influenced by tumour size, location, stage, and symptoms of the patient. Limited resection is considered in cases of non-invasive and small lesions that are usually less than 2cm. Surgery with lymph nodal resection is recommended for small-bowel NETs. Surgery can be curative in the presence of liver metastases with a five-year survival rate of about 60-80%. 48 In the presence of focal liver lesion, partial hepatic resection can be performed with the primary tumour resection. However, resection of liver is not considered in the presence of multifocal liver disease. 48

Oncological Management

If surgery is not possible due to aggressive local disease or extensive metastatic spread of disease, then medical management is mandatory to relieve the symptoms and regress tumour spread and growth. 49 When metastatic liver lesions are present, then complete metastatectomy has been suggested, if feasible. 50 Procedures targeting the liver lesions such as trans-arterial chemo embolization, ablative therapies or internal radiation with yttrium-90 microspheres has also been advocated. 51 Peptide receptor radionuclide therapy (PRRT) was developed because many receptors are visualised via the radiotracers, therefore, use of radio-isotopes for therapeutic purpose could provide an effective means for treatment of NET with distant spread. PRRT is available in Europe under local guidelines. 52 177

Lu-[DOTA0,Tyr3] octreotate therapy is one such treatment for disseminated NET and provides benefit in overall survival with few adverse effects and response rate comparable to other alternative treatment options. 53 A recent trial has shown that use of PRRT leads to an increase in progression-free survival. 54 Somatostatin receptor analogues (SSAs) such as octreotide or lanreotide also have an impact on progression-free survival and are used as first-line in low grade NETs. 55 Trials of interferon alpha and molecular agents such as everolimus, sunitinib and bevacizumab have also been undertaken for the treatment of NETs that have metastatic spread or extensive local spread of disease. 56-59


A multidisciplinary approach is mandatory for follow-up of NETs. This includes biochemical (chromogranin A levels, hormonal assays and vasoactive amines), radiological, and histological evaluation. 60 Dynamic contrast-enhanced CT or MR imaging plays a central role in long-term assessment after surgery. The follow-up protocol usually includes imaging at every 6 months for the first year and then annually, if negative. For intermediate and high grade tumours, a shorter 3-month follow-up is indicated. Three-month follow-up is also recommended for patients undergoing treatment. 60


The review covered the aetiology, diagnosis, staging, imaging techniques, imaging features and treatment of these rare tumours that need a prompt diagnosis.

Disclaimer: None.

Conflict of Interest: None.

Source of Funding: None.


1. Ronot M, Cuccioli F, Burgio MD, Vullierme MP, Hentic O, Ruszniewski P, et al. Neuroendocrine liver metastases: Vascular patterns on triple-phase MDCT are indicative of primary tumour location. Eur J Radiol 2017; 89: 156-62.

2. Biaikowska J, Kolasi?ska-?wik?a A, Mroczkowska D, Sowa M, Grabarczyk?, Maksymowicz W, et al. Disseminated Pancreatic Neuroendocrine Neoplasm (NEN) with an Uncommon Localisation in the Central Nervous System. A Case Report. Pol J Radiol 2017; 82: 120-5.

3. Katabathina VS, Vikram R, Olaoya A, Paspulati RM, Nicolas MM, Rao P, et al. Neuroendocrine neoplasms of the genitourinary tract in adults: cross-sectional imaging spectrum. Abdom Radiol 2017; 42: 1472-84.

4. Kang JH, Kim SH, Han JK. Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from well-differentiated neuro endocrine tumour and poorly-differentiated adenocarcinomas. Eur Radiol 2017; 27: 3867-76.

5. Zhu H, Ying L, Tang W, Yang X, Sun B. Can MDCT or EUS features predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms? Radiol Med 2017; 122: 319-26.

6. Toshima F, Inoue D, Komori T, Yoshida K, Yoneda N, Minami T, et al. Is the combination of MR and CT findings useful in determining the tumour grade of pancreatic neuroendocrine tumours? Jpn J Radiol 2017; 35: 242-53.

7. Choi TW, Kim JH, Yu MH, Park SJ, Han JK. Pancreatic neuroendocrine tumour: prediction of the tumour grade using CT findings and computerized texture analysis. Acta Radiol 2018; 59: 383-92.

8. De Robertis R, Paiella S, Cardobi N, Landoni L, Martini PT, Ortolani S, et al. Tumour thrombosis: a peculiar finding associated with pancreatic neuroendocrine neoplasms. A pictorial essay. Abdom Radiol 2018; 43: 613-9.

9. Turaga KK, Kvols LK. Recent progress in the understanding, diagnosis, and treatment of gastroenteropancreatic neuroendocrine tumours. CA Cancer J Clin 2011; 61: 113-32.

10. Heller MT, Shah AB. Imaging of neuroendocrine tumours. Radiol Clin North Am 2011; 49: 529-48.

11. Palepu J, Shrikhande SV, Bhaduri D, Shah RC, Sirohi B, Chhabra V, et al. Trends in diagnosis of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) in India: A report of multicenter data from a web-based registry. Indian J Gastroenterol 2017; 36: 445-51.

12. Bukhari MH, Niazi S, Shah N, Anwar M, Khalee EM, Samina Q, et al. Histological Diagnosis and Frequency of Primary Endocrine Tumours (ETs) and Neuroendocrine Tumours (NETs) According to WHO Classification. Int J Endocrinol Metab 2008; 2008: 205-14.

13. Haugvik SP, Hedenstrom P, Korsaeth E, Valente R, Hayes A, Siuka D, et al. Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis. Neuroendocrinology 2015; 101: 133-42.

14. Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumours. Endocrinol Metab Clin North Am 2011; 40: 1-18.

15. Oberg K. Pancreatic endocrine tumours. Semin Oncol 2010; 37: 594-618.

16. Stratakis CA. Hereditary syndromes predisposing to endocrine tumors and their skin manifestations. Rev Endocr Metab Disord 2016; 17: 381-8.

17. Fink G, Krelbaum T, YellinA, Bendayan D, Saute M, Glazer M, et al. Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001; 119: 1647-51.

18. Pavel M, Costa F, Capdevila J, Gross D, Kianmanesh R, Krenning E, et al. ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site. Neuroendocrinology 2016; 103: 172-85.

19. Iyer R, Phan AT, Boudreaux JP. Recent advances in the management of gastroenteropancreatic neuroendocrine tumors: insights from the 2017 ASCO Gastrointestinal Cancers Symposium. Clin Adv Hematol Oncol 2017; 15 (Suppl 4): 1-24.

20. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 2008; 9: 61-72.

21. Hirabayashi K, Zamboni G, Nishi T, Tanaka A, Kajiwara H, Nakamura N. Histopathology of gastrointestinal neuroendocrine neoplasms. Front Oncol 2013; 3: 2.

22. Perren A, Couvelard A, Scoazec JY, Costa F, Borbath I, DelleFave G, et al. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pathology-Diagnosis and Prognostic Stratification. Neuroendocrinology 2017; 105: 196-200.

23. Kim JY, Hong SM. Recent updates on neuroendocrine tumours from the gastrointestinal and pancreatobiliary tracts. Arch Pathol Lab Med 2016; 140: 437-48.

24. Schmitt AM, Riniker F, Anlauf M, Schmid S, Soltermann A, Moch H, et al. Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumours and their metastases. Am J Surg Pathol 2008; 32: 420-5.

25. Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population?based to a more "personalized" approach to cancer staging. CA Cancer J Clin 2017; 67: 93-9.

26. Sahani DV, Bonaffini PA, Fernandez-Del Castillo C, Blake MA. Gastroenteropancreatic neuroendocrine tumours: role of imaging in diagnosis and management. Radiology 2013; 266: 38-61.

27. Gibril F, Jensen RT. Diagnostic uses of radiolabelled somatostatin receptor analogues in gastroenteropancreatic endocrine tumours. Dig Liver Dis 2004; 36: S106-20.

28. Tan EH, Tan CH. Imaging of gastroenteropancreatic neuroendocrine tumours. World J Clin Oncol 2011; 2: 28-43.

29. Kulke MH, Anthony LB, Bushnell DL, De Herder WW, Goldsmith SJ, Klimstra DS, et al. NANETS treatment guidelines: well differentiated neuroendocrine tumours of the stomach and pancreas. Pancreas 2010; 39: 735-52.

30. Tamm EP, Kim EE, Ng CS. Imaging of neuroendocrine tumours. Hematol Oncol Clin North Am 2007; 21: 409-32.

31. Ichikawa T, Peterson MS, Federle MP, Baron RL, Haradome H, Kawamori Y, et al. Islet cell tumour of the pancreas: biphasic CT versus MR imaging in tumour detection. Radiology 2000; 216: 163-71.

32. Alsohaibani F, Bigam D, Kneteman N, Shapiro AM, Sandha GS. The impact of preoperative endoscopic ultrasound on the surgical management of pancreatic neuroendocrine tumours. Can J Gastroenterol 2008; 22: 817-20.

33. Deroose CM, Hindie E, Kebebew E, Goichot B, Pacak K, Taieb D, et al. Molecular imaging of gastroenteropancreatic neuroendocrine tumors: current status and future directions. J Nucl Med 2016; 57: 1949-56.

34. Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumours: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 2007; 48: 508-18.

35. Buchmann I, Henze M, Engelbrecht S, Eisenhut M, Runz A, Schafer M, et al. Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2007; 34: 1617-26.

36. Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?. Eur J Nucl Med Mol Imaging 2007; 34: 982-93.

37. Pettinato C, Sarnelli A, Di Donna M, Civollani S, Nanni C, Montini G, et al. 68Ga-DOTANOC: biodistribution and dosimetry in patients affected by neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2008; 35: 72-9.

38. Prasad V, Baum RP. Biodistribution of the Ga-68 labeled somatostatin analogue DOTA-NOC in patients with neuroendocrine tumours: characterization of uptake in normal organs and tumour lesions. Q J Nucl Med Mol Imaging 2010; 54: 61-7.

39. Ambrosini V, Campana D, Polverari G, Peterle C, Diodato S, Ricci C, et al. Prognostic value of 68Ga-DOTANOC PET/CT SUVmax in patients with neuroendocrine tumors of the pancreas. J Nucl Med 2015; 56: 1843-8.

40. Poeppel TD, Binse I, Petersenn S, Lahner H, Schott M, Antoch G, et al. 68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumours. J Nucl Med 2011; 52: 1864-70.

41. Lewis RB, Lattin Jr, Maj GE, Paal E. Pancreatic endocrine tumours: radiologic-clinicopathologic correlation. Radiographics 2010; 30: 1445-64.

42. Raman SP, Hruban RH, Cameron JL, Wolfgang CL, Fishman EK. Pancreatic imaging mimics: part 2, pancreatic neuroendocrine tumours and their mimics. AJR Am J Roentgenol 2012; 199: 309-18.

43. Levy AD, Sobin LH. From the archives of the AFIP: Gastrointestinal carcinoids: imaging features with clinicopathologic comparison. Radiographics 2007; 27: 237-57.

44. Levy AD, Taylor LD, Abbott RM, Sobin LH. Duodenal carcinoids: imaging features with clinical-pathologic comparison. Radiology 2005; 237: 967-72.

45. Ganeshan D, Bhosale P, Yang T, Kundra V. Imaging features of carcinoid tumours of the gastrointestinal tract. AJR Am J Roentgenol 2013; 201: 773-86.

46. Horton KM, Kamel I, Hofmann L, Fishman EK. Carcinoid tumours of the small bowel: a multitechnique imaging approach. AJR Am J Roentgenol 2004; 182: 559-67.

47. DelleFave G, Sundin A, Taal B, Ferolla P, Ramage JK, Ferone D, et al. ENETS consensus guid eli nes upd ate for gastroduodenal neuroendocrine neoplasms. Neuroendocrinology 2016; 103: 119-24.

48. Harring TR, Nguyen NT, Goss JA, O'Mahony CA. Treatment of liver metastases in patients with neuroendocrine tumours: a comprehensive review. Int J Hepatol 2011; 2011: 154541.

49. Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, et al. ENETS consensus guidelines for high-grade ga stroe ntero pancreatic neuroendocri ne tu mors and neuroendocrine carcinomas. Neuroendocrinology 2016; 103: 186-94.

50. Frilling A, Modlin IM, Kidd M, Russell C, Breitenstein S, Salem R, et al. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncol 2014; 15: e8-21.

51. Peker A, Cicek O, Soydal C, Kucuk NO, Bilgic S. Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases. Diagn Interv Radiol 2015; 21: 54-9.

52. Zaknun JJ, Bodei L, Mueller-Brand J, Pavel ME, Baum RP, Horsch D, et al. The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2013; 40: 800-16.

53. Brabander T, Van der Zwan WA, Teunissen JJ, Kam BL, Feelders RA, de Herder WW, et al. Long-term efficacy, survival and safety of [177Lu-DOTA0, Tyr3] octreotate in patients with gastroenteropancreatic and bronchial neuroendocrine tumors. Clin Cancer Res 2017; 23: 4617-24.

54. Lopera Sierra M, Kwekkeboom D, Mariani MF, Bodei L, Santoro P, Krenning EP. 1165TiP NETTER-1: first pivotal phase III study evaluating 177lu-dotatate in midgut neuroendocrine tumours. Ann Oncol 2014; 25(Suppl. 4): iv405.

55. Yao JC, Lagunes DR, Kulke MH. Targeted Therapies in neuroendocrine tumours (NET): clinical trial challenges and lessons learned. Oncologist 2013; 18: 525-32.

56. Mirvis E, Mandair D, Garcia-Hernandez J, Mohmaduvesh M, Toumpanakis C, Caplin M. Role of interferon-alpha in patients with neuroendocrine tumours: a retrospective study. Anticancer Res 2014; 34: 6601-7.

57. Yao JC, Fazio N, Singh S, Buzzoni R, Carnaghi C, Wolin E, et al. Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study. Lancet 2016; 387: 968-77.

58. Faivre S, Niccoli P, Castellano D, Valle JW, Hammel P, Raoul JL, et al. Sunitinib in pancreatic neuroendocrine tumors: updated progression-free survival and final overall survival from a phase III randomized study. Ann Oncol 2016; 28: 339-43.

59. Yao JC, Phan A, Hoff PM, Chen HX, Charnsangavej C, Yeung SC, et al. Targeting vascular endothelial growth factor in advanced carcinoid tumour: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 2008; 26: 1316-23.

60. Arnold R, Chen YJ, Costa F, Falconi M, Gross D, Grossman AB, et al. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumours: follow-up and documentation. Neuroendocrinology 2009; 90: 227-33.
COPYRIGHT 2019 Knowledge Bylanes
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2019 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Journal of Pakistan Medical Association
Article Type:Report
Date:Apr 30, 2019
Previous Article:Knowledge and perceptions about Pre-diabetes amongst doctors, medical students, and patients in a tertiary care hospital of Islamabad.
Next Article:Social Media and Ethos of Medical Practice.

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |