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GENOME TEST ENABLES RECONSTRUCTION OF PHYSICAL PROFILE.

DNAPrint genomics, Sarasota, Fla., has upgraded its DNAWitness(TM) 2.5 product for physical profiling from DNA with a proprietary database designed to help investigators learn what their results say, or don't say, about physical appearance.

The DNAWitness(TM) 2.5 genome test allows forensics investigators to employ objective science, empiricism and statistical analysis in the reconstruction of a physical profile or "fuzzy photo" from DNA left at a crime scene. It employs the world's first molecular genetics test for the inference of BioGeographical Ancestry (BGA) admixture. For example, DNA at a crime scene may indicate that a person is of 90% East Asian, 10% European mix. BGA is obviously related to physical appearance, and individuals with fewer admixtures tend to have more accentuated anthropometric characteristics (those that vary from race to race). Investigators who obtain a result such as 100% East Asian typically have little difficulty interpreting the result, but investigators who, for example, obtain a result such as 70% European, 30% East Asian usually ask whether the person's physical appearance would reveal the East Asian admixture. Communicating how BGA relates to physical appearance is difficult to do with words in a scientific way, but the advance announced today is the first solution for this problem.

To project what a person may look like from knowledge of their DNA, DNAPrint has developed the DNAWitness(TM) 2.5 database of individual BGA admixture results. The database contains information on how individuals previously tested have self-defined in terms of ethnicity (called the "geopolitical" arm of the database) as well as their digital photographs. By querying the database using a specific BGA admixture result, investigators can see for themselves what the range of variability is corresponding to that result for various features, such as skin shade, hair texture, nose shape, epicanthal eye folding, etc. Whether or not, for example, individuals of 70% European, 30% East Asian admixture tend to show no East Asian features, would be apparent from the database query.

Statistical tools soon to be added will allow investigators to use Analysis of Molecular Variance to determine whether there is a systematic difference in the expression of an anthropometric trait that can be measured from the photograph in one database sample set versus the international average, or versus another group. DNAPrint has already filed patent applications on the use of digital photograph databases and databases of biographical data with BioGeographical Ancestry admixture data.

About DNAPrint genomics, Inc.

DNAPrint genomics, Inc. uses proprietary human genome research methods to develop genomic-based services and products. The company introduced AncestryByDNA in the consumer market and DNAWitness(TM) in the forensic market in 2003. DNAPrint is developing products in the pharmacogenomic market and has a disease gene discovery program. The company is traded on the Nasdaq OTC Bulletin Board under the ticker symbol: DNAP.

For more information, visit http://www.dnaprint.com or call 941\366-3400.
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Publication:Online Product News
Date:Oct 1, 2004
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