Further evidence on the effectiveness of potato juice in dyspeptic complaints.
Biotta AG Tagerwilen produced a 5-fold concentrate of the potato juice (for HPLC see Chrubasik et al., 2005) for a pilot study carried out in Dniepropetrovsk, Ukraine. After the State Committee on Food Supplements approved the study, 6 men and 12 women suffering from dyspeptic complaints (Table 1) volunteered to take the potato juice concentrate, starting with 2 teaspoons/day (morning and evening or more, if necessary). Two patients dropped out, a patient who had no gastroscopic diagnosis withdrew his consent and another patient who suffered from dry cough prior to entry to this trial, the first dose of the concentrate was associated with a coughing attack, such that she decided not to continue with the treatment.
Three of the patients took 2 teaspoons/day of the concentrate, nine took 3 teaspoons/day and five consumed 3 tablespoons/day. Three outcome indicators were used. The GIS score, improvement in the worst rated GIS symptom (where more than 1 component had the same worst score before treatment, the 1 with the least improvement was chosen as the outcome variable) and self-rated efficacy. After 6 days, the GIS score had improved by 73 [+ or -] 32% (ITT, mean [+ or -] SD p < 0.001). The absolute GIS values improved from 12.8 [+ or -] 4.3 to 3.1 [+ or -] 3.7, the subjects' worst GIS symptom improved in 15 by a median score of 2 (Fig. 1). Of the 3 non-improvers, 2 were the patients who withdrew, and in the remaining one, of 6 GIS components which were rated as 2 at commencement of treatment, 5 had improved. The doses of the medication used did not correlate with either outcome variable, neither did age, nor sex, weight, BMI or the duration of acute or chronic symptoms. Fourteen patients improved their GIS by 60% or more and 10 patients rated the efficacy of the treatment as very good or good. Failure of the treatment was not observed in any of the patients.
[FIGURE 1 OMITTED]
This pilot trial indicates, that the 5-fold concentrate of potato juice may be more effective in alleviating dyspeptic complaints than ordinary potato juice. A confirmatory clinical study should now be carried out to compare their effectiveness.
Chrubasik, S., Chrubasik, C., Torda, T., Madisch, A., 2005. Efficacy and tolerability of potato juice in dyspeptic patients: a pilot study. Phytomedicine, in press.
Holtmann, G., Adam, B., Frote, E., Saadat-Gilani, K., Vinson, B., 2004. Validation of the gastrointestinal symptom score (GIS) in patients with functional dyspepsia. Z. Gastroenterol. 42, T1179.
Madisch, A., Kulich, K.R., Malfertheimer, P., Ziegle, K., Bayerdorffer, E., Miehlke, S., Labenz, J., Carlsson, J., Wiklund, I.K., 2003. Impact of reflux disease on general and disease-related quality of life--evidence from a recent comparative methodological study in Germany. Z. Gastroenterol. 41, 1137-1143.
Department of Forensic Medicine, University of Freiburg, Albertstr. 9, 79104 Freiburg, Germany
E-mail address: sigrun.Chrubasik@klinikum.uni-freiburg.de
S. Chrubasik*, T. Boyko, Y. Filippov
Department of Gastroenterology, Ukraine Academy of Medical Science, Dniepropetrovsk, Ukraine
E-mail address: firstname.lastname@example.org (T. Boyko)
School of Medical Sciences, University of New South Wales, Sydney, Australia
E-mail address: email@example.com
Table 1. Baseline characteristics of the 18 patients (mean [+ or -] SD, or numbers of patients) Age (yr) 48 [+ or -] 15 Weight (kg) 70 [+ or -] 18 Height (cm) 167 [+ or -] 9 Duration of chronic symptoms (mths) 105 [+ or -] 120 Duration of acute exacerbation (wks) 33 [+ or -] 51 Diurnal distribution of symptoms Morning 5 Noon 10 Afternoon 1 Evening 10 At night 2 Continuous complaints 3 Intermittent complaints 15 Risk factors Regular alcohol consumption 2 Regular nicotine consumption 3 Regular consumption of spices 3 Use of synthetic medications 3 Endoscopic diagnoses (multiple) Gastroduodenitis 4 Reflux oesophagitis 11 Duodenal ulcer 2 Deformation after duodenal ulcer 1 Gastritis 2 No gastroscopy 1
|Printer friendly Cite/link Email Feedback|
|Title Annotation:||LETTER TO THE EDITOR|
|Author:||Chrubasik, S.; Boyko, T.; Filippov, Y.; Torda, T.|
|Publication:||Phytomedicine: International Journal of Phytotherapy & Phytopharmacology|
|Date:||Sep 1, 2006|
|Previous Article:||Bioactivity-guided fractionation of Coronopus didymus: a free radical scavenging perspective.|
|Next Article:||Potential molecular basis of the chondroprotective effect of Harpagophytum procumbens.|