Printer Friendly

Fruit fly study reveals possible therapeutic target for pancreatic cancer.

Byline: ANI

Washington, December 15 (ANI): New studies on the fruit fly Drosophila melanogaster have suggested that pancreatic cancer, the most lethal form of human cancer, may be treated by targeting proteins whose DNA recipe comes from the gene Seven-In-Absentia (SINA).

While presenting their work at the ongoing 48th annual meeting of the American Society for Cell Biology (ASCB) in San Francisco, researchers from the Minnesota-based Mayo Clinic College of Medicine revealed that they had found a link between the SINA gene and the aggressive cellular transformation, oncogenesis and metastasis that characterize pancreatic cancer.

The researchers said that the 'Seven-In-Absentia-Homolog' (SIAH) protein seems to be work as a check and balance mechanism in the K-RAS gene, which is known to underlie the abnormal cell growth of pancreatic cancer.

Lead researcher Amy Tang said that SIAH was found to turn off the excessive growth-promoting proteins produced by the hyperactive, mutated form of the gene, during the study.

"By attacking the SIAH-based protein degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," she said.

Based on their observations, the researchers came to the conclusion that SIAH might be an attractive new target for novel anti-RAS and anti-cancer therapy in pancreatic cancer, the median survival of which is only six months, and the mortality rate is 95 percent.

Tang said that inhibiting SIAH function enabled her team to completely abolish both tumorigenesis and metastasis of human pancreatic cancer cells, which were growing in "nude" mice that have immune system deficits that prevent them from rejecting foreign tissue.

"It is likely to move into the clinical setting for study as an interventional treatment in pancreatic cancer in human patients," Tang said, referring to the SIAH inhibition.

She said that, in humans, the SIAH ubiquitin ligases sit smack in the middle of the molecular pathway that leads to pancreatic cancer.

Her team found that SIAH ubiquitin ligases were specifically and markedly "upregulated" in pancreatic cancers.

The increased SIAH expression seemed to correlate with aggressiveness of pancreatic cancer. Moreover, SIAH is normally required for mammalian K-RAS signal transduction. (ANI)

Copyright 2008 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2008 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2008 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Dec 15, 2008
Previous Article:Atlantis opens in Dubai with most expensive launch party in history.
Next Article:UK troops to withdraw from Iraq early next year if polls go off smoothly.

Related Articles
Current issues in the treatment of pancreatic cancer.
Researchers identify gene alterations in pancreatic cancer.
GOOD LIFE CAN CUT CANCER BY 40%; Diet and exercise are keys to avoiding disease, say experts.
Drug-combo could prevent pancreatic cancer recurrence.
New tool can detect pancreatic cancer more effectively than current tests.
New advance in pancreatic cancer.
Abnormal genes in DNA repair may help predict pancreatic cancer risk.
Two or more drinks a day 'up pancreatic cancer risk'.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters