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Frequency of hair loss in lesions of pityriasis versicolor.

Byline: Ayesha Munir, Nighat Akbar and Farid ur Rehman

Keywords: Hair loss, pityriasis versicolor.

Introduction

Pityriasis versicolor (PV) is a superficial fungal infection of skin, caused by genus Malassezia.1 M. globosa, M. furfur and M. sympodialis are the predominant species isolated in the Indian subcontinent.2

Infection depends upon factors including climate, occupation and socioeconomic conditions. Hot and humid environment favours its growth. Males and females are equally affected. Increased incidence is reported in Cushing disease, immunosuppression and malnourishment.3-5

The typical lesion is a sharply demarcated macule with branny scaling commonly found on upper trunk, followed by arms, neck and abdomen. Face and scalp are also affected.6

It presents a considerable disease burden in Pakistan due to its favourable climate. In a study conducted at Lahore, frequency of fungal infections was 12.5% amongst geriatric population.7

It is a dimorphic fungus, existing in its yeast form as a normal commensal of human body, transforming to pathological mycelial state in favourable circumstances.8 In approximately 20% of cases, a familial predisposition is found.9

Diagnosis can generally be made clinically and confirmed by the golden yellow fluorescence of lesions on Wood's light examination. Affected specimens consist mainly of hyphae with clusters of spherical yeasts, well recognized as 'the spaghetti and meatball appearance on KOH mounted skin scrappings.10-12

Previously, it was thought that hair shaft is not affected in PV.13 Hair loss was never documented until recently. A study conducted by Mostafa et al.14 described hair loss in the lesions of PV. In this study, hair loss/thinning was observed clinically in 61.5% of the patients, while histopathologically, it was shown in 46.2% of lesional and 20.5% of nonlesional skin.14

Malassezia may induce pathological changes in hair follicles either by direct toxicity or through production of various cytokines inducing apoptosis, as a part of keratinocytes response to presence of fungus. Keratinocytes produce a range of proinflammatory and immunoregulatory cytokines, which might favor induction of immune response and lymphocyte proliferation as well as pathological changes in hair follicles.15

The clinical finding of hair loss supported by histopathological evidence opens up a new perspective of the disease, as the condition now merits a serious consideration, amongst others, when a patient presents to a dermatologist for hair loss. Also, the impact of cosmetic disfigurement will be much greater when the disease presents on scalp, face or beard area with hair loss also as part of the disease. This implies that a common practice of short-term topical treatment may need to be reviewed, a follow-up for recurrence and chronicity of the disease may be advised and a systemic or prolonged course of the treatment, as well as, prophylaxis in cases of recurrent disease may be planned.

Methods

It was a cross-sectional study done over six months period starting from September, 2014 to March, 2015 carried out at the department of Dermatology, Fauji Foundation Hospital, Rawalpindi, Pakistan. Nonprobability consecutive sampling was done. Using WHO sample size calculator with confidence interval 95%, anticipated population proportion 46.2%, absolute precision regained 10%, sample size of 125 patients was calculated. Permission for this study was obtained from Hospital Ethical Committee.

Patients of either sex having PV clinically, between 10 to 50 years old, not on topical or systemic treatment for PV for the past 4 weeks were included. Patients having systemic illnesses associated with hair loss like postpartum hair loss, thyroid disease and medical therapy known to cause hair loss like drugs and radiations were excluded. Patients were free to withdraw from the study at any point during the study.

Patients fulfilling the stated criteria were recruited after informed consent through dermatology OPD Fauji Foundation Hospital. Patients with clinical suspicion of PV were examined under Wood's light for fluorescence. Two punch biopsies were taken from each patient, one from the lesional and other from the nonlesional skin under local anesthesia. Biopsies included at least one hair follicle or follicular ostium. The punch biopsies, as well as, their histopathological examination was done free of cost by Fauji Foundation Hospital dermatology department and pathology department, respectively.

Hair follicles in the affected skin were compared with the follicles in the unaffected skin. Evidence of atrophy was seen as "shrunken" or "fading follicles", when compared to the overall size of dermis and other cutaneous adnexa and to the follicles of the nonlesional skin. Miniaturized follicles were identified microscopically by decreased dermal papilla size, decrease in hair matrix and hair shaft diameter.

Data was entered and analyzed in SPSS version 10.0. Categorical variables like hair loss, site of lesions were described in terms of frequencies and percentages while mean with or without standard deviation was computed for quantitative variables like age and duration of symptoms. Effect modifiers like age, gender, duration and site of lesion were controlled by stratification. Poststratification chi-square test was applied. P value of <0.05 was considered significant.

Results

125 patients were included in the study. Patients were of different ages. Mean age of the sample (years) was 20.98+-9.05. Minimum and maximum age was 11 and 52 years, respectively. Majority of the study population was female i.e. 64%, while 36% were males.

Patients had a history of lesions from minimum of one month duration to a maximum of two years. Mean duration of lesions (months) was 3.78+-1.87.

Out of 125 patients, maximum patients i.e. 34 (27.2%) had lesions on their back, similarly 23 (18.4%) patients had lesions on their chest. There were 5 (4.0%) patients who had lesions on their face.

Out of 125 patients, there were 72 (57.6%) patients who presented with hair loss within the lesions.

There were 65 (90.3%) patients less than 30 years of age having hair loss within the lesions of PV, whereas there were 7 (9.7%) patients aged more than 30 years, found to have hair loss within the lesions (p value 0.361).

There were 28 (38.9%) male patients who presented with hair loss within the lesions of PV, whereas 44 (61.1%) female patients had hair loss within the lesions (p value 0.433).

There were 71 (98.6%) patients with hair loss with the disease duration of less than a year. Whereas there was only one patient with hair loss in lesions who had the disease for more than one year (p value 0.389)

There were 20 (27.8%) patients who predominantly had the disease on their back, whereas there were 12 (16.7%) patients with predominant involvement of their chest (p value 0.671).

Discussion

Majority of the patients in this study were young adults. 90% of the study population were 0.05). Hence, hair loss occurring in PV cannot be linked to any of these variables, and possible etiology needs to be further worked up.

It may be hypothesized that presence of hair loss in a particular individual, within the lesions of PV is related to individual's immune response, which determines the ability to induce cytokine production by human keratinocytes among Malassezia yeasts.

It may explain why hair loss occurs in some individuals having PV and not in others. It may also be suggested that certain Malassezia species, amongst all causing PV, are capable of inducing hair loss, as different Malassezia species have been shown to be associated with a different cytokine profile and some of the induced cytokines have been shown to inhibit follicle activity.14,15 However, no study as yet ascertains the factors predisposing an individual to hair loss when affected by PV.

The finding of hair loss occurring within the lesions of PV has certain important implications. Firstly, it should be considered as a differential diagnosis, amongst others, in patients presenting with hair loss. This is particularly important when alopecia areata is being considered as a cause of patchy hair loss, as many a time topical or intralesional steroid treatment is started without obtaining a skin biopsy for histopathological diagnosis of alopecia areata. In this case, if PV was the underlying pathology, the immunosuppressive effect of steroids may lead to extensive disease and aggravation of hair loss.

Another important implication of this novel finding is to make Wood's lamp examination an essential part of clinical examination in a patient presenting with patchy hair loss. A regular practice of Wood's lamp examination may prove useful, as the infection may be subclinical and not associated with pigmentary changes of skin, which is the usual presentation of PV.

Thirdly, a greater cosmetic disfigurement is associated with PV due to the presence of hair loss in addition to pigmentary changes in skin colour, particularly in cases involving scalp and face, especially the beard area in men.14

This may also have a particular impact on common practice of short-term topical antifungal treatment of PV, as systemic therapy may be needed or a prolonged treatment course may be devised.

Fourthly, in cases of frequent recurrences, prophylaxis may be advised and patients with chronic infection may be called for regular follow up to check treatment response and to prevent the development of alopecia.

Fifthly, additional studies need to be performed to further explore this aspect of the disease such as mycological cultures and PCR to identify the specific Malassezia species that can cause hair loss. The immunohistochemical identification of the role of various cytokines influencing hair growth also needs to be explored.

Conclusion

Hair loss occurs in a significant number of cases of pityriasis versicolor, which is a novel aspect of the disease. In view of diagnostic accuracy in cases of nonscarring, patchy hair loss and the cosmetic disfigurement associated with hair loss, further studies are required to explore the etiology and pathogenesis of this phenomenon and a revision of treatment guidelines is required to ensure that follicular damage associated with this disease is appropriately taken care of.

References

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2. Kaur M, Narang T, Bala M, Gupte S, Aggarwal P, Manhas A. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tertiary Care Hospital, Punjab. Indian J Med Microbiol. 2013;31:270-4.

3. Banarjee SAL. Clinical profile of pityriasis versicolor in referral hospital of West Bengal. J Pak Assoc Dermatol. 2011;21:248-52.

4. da Fraga, CMM, de Cassia Birschiner R, Naseri AP, Diniz LM. Influence of systemic corticotherapy on the triggering of pityriasis versicolor. Mycoses. 2014;57:565-71.

5. Lima AM, Rocha SP, Reis Filho EG, Eid DR, Reis CM. Study of dermatoses in kidney transplant patients. An Bras Dermatol. 2013;88:361-7.

6. Afshar P, Ghasemi M, Kalhori S. Identification of Malassezia Species isolated from Patients with Pityriasis Versicolor in Sari, Iran, 2012. Jundishapur J Microbiol. 2013;6(6):15.

7. Khurshid K, Irfanullah, Paracha MM, Amin S, Pal SS. Frequency of Cutaneous Diseases in Geriatric population of Type 1V and V skin. J Postgrad Med Inst. 2012;58:195-8.

8. Crespo-Erchiga V, Florencio VD. Malassezia yeasts and pityriasis versicolor. Curr Opin Infect Dis. 2006;19:139-47.

9. Shah A, Koticha A, Ubale M, Wanjare S, Mehta P, Khopkar U. Identification and speciation of Malassezia in patients clinically suspected of having pityriasis versicolor. Indian J Dermatol. 2013;58:239.

10. Zeinali E, Sadeghi G, Yazdinia F, Shams-Ghahfarokhi M, Razzaghi-Abyaneh M. Clinical and epidemiological features of the genus Malassezia in Iran. Iran J Microbiol. 2014;6(5):354-60.

11. Mollet I, Ongenae K, Naeyaert JM. Origin, clinical presentation, and diagnosis of hypomelanotic skin disorders. Dermatol Clin. 2007;25:363-71.

12. Kelly BP. Superficial fungal infections. Pediatr Rev. 2012;33(4):e22-37.

13. Hay RJ, Ashbee HR. Mycology. In: Burns T, Breathnach S, Cox N, Griffith C, editors. Rook's Textbook of Dermatology. 8th ed. Oxford: Wiley-Blackwell; 2010. p.36.10-36.12.

14. Mostafa WZ, Assaf MI, Ameen IA, El Saoury OS, Al Sulh SA. Hair loss in pityriasis versicolor lesions: A descriptive clinicopathological study. J Am Acad Dermatol. 2013;69:e19-23.

15. Ashbee HR. Recent developments in the immunology and biology of Malassezia species. FEMS Immunol Med Microbiol. 2006;47(1):14-23.

16. Thayikkannu AB, Kindo AJ, Veeraraghavan M. Malassezia-Can it be ignored? Indian J Dermatol. 2015;60(4):332-9.

17. He SM, Du WD, Yang S, Zhou SM, Li W, Wang J et al. The genetic epidemiology of tinea versicolor in China. Mycoses. 2008; 51(1):55-62.
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Publication:Journal of Pakistan Association of Dermatologists
Date:Dec 31, 2018
Words:2222
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