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France : HUMAN LUTEINIZING HORMONE.

Project status:Accepted

Project Funding: 150000 EURO (197775.00 US Dollar)

Programme Acronym: BCR 4

Programme type:Second Framework Programme

General information: Luteinizing hormone (LH) is a glycoprotein secreted by the anterior portion of the pituitary gland. In the male, LH controls testosterone secretion. In the female, at about the midpoint of the cycle, as a result of the action of LH, an ovum is released and progesterone secretion begins. Measurement of serum LH has proved useful in a variety of conditions including hypogonadism, ovulation and infertility studies. Serum assay of glycoproteic hormones is complicated by the fact that these molecules are circulating under different forms that vary according to the physiological and pathological status of the patients.

The project is intended to improve the comparability of the assays of LH in serum. The means to achieve this objective involve the epitope mapping of several preparations of LH using monoclonal antibodies (mAbs). This should permit to identify mAbs reacting with epitopes constantly present on the surface of all LHs or conversely with epitopes expressed by LH in specific situations. The bioactivity and structure of LH isoforms will probably be assessed.

country :France

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Publication:Mena Report
Date:Jan 3, 2013
Words:205
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