Printer Friendly

France,Switzerland,United Kingdom,United States : ISIS PHARMACEUTICALS gets $1 million milestone payment from GLAXOKLINESMITH.

Isis Pharmaceuticals, Inc. earned $1 million milestone payment from GlaxoSmithKline pertaining to the advancement of ISIS-TTR in a randomized, double-blind, placebo-controlled phase II/III study in patients suffering from familial amyloid polyneuropathy (FAP).

The study evaluates the effects of ISIS-TTR on neurological dysfunction and the quality of life of the patients. Results support the filing of a marketing approval application of ISIS-TTR for the indication.

Isis Pharma inked a deal with Glaxo in March 2010 for the development of up to 6 programs. The companies are working on 5 active programs, which include ISIS-TTR.

Isis Pharma will receive total milestone payments of $50 million from Glaxo for the development of ISIS-TTR. The payment of $1 million marks the 4th installment. To date, Isis Pharma has received $26 million, including upfront and milestone payments.

Glaxo has an option to exclusively license ISIS-TTR. Isis Pharma will receive license and regulatory fees, sales milestone payments and double-digit royalties on ISIS-TTR net sales, if Glaxo exercises this option.

Isis Pharma and Glaxo are conducting an open-label extension study on ISIS-TTR in FAP patients who have completed dosing in the phase II/III study.

Isis Pharma has partnership agreements with leading pharmaceuticals companies like Biogen Idec and Roche among others.

Isis Pharma earned a milestone payment of $14 million from Biogen to initiate a phase I study on ISIS-DMPK for the treatment of myotonic dystrophy type I.

2014 Al Bawaba ( Provided by SyndiGate Media Inc. ( ).

COPYRIGHT 2014 SyndiGate Media Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2014 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Mena Report
Date:Jun 28, 2014
Previous Article:Ethiopia,Norway : NORWAY makes 60mln dollar financial support for building green economy in ETHIOPIA.
Next Article:United Kingdom : EE decides to switch on 4G mobile broadband in NEWTON ABBOT.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters